SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o1m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 10 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.89A 1pxxA-4o1mA:
undetectable		 1pxxA-4o1mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.89A 1pxxC-4o1mA:
undetectable		 1pxxC-4o1mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 ILE A 244
LEU A 261
TYR A  23
ALA A 231
SER A 229
 None
None
NAD  A 401 (-4.9A)
NAD  A 401 (-3.2A)
NAD  A 401 (-2.7A)
 1.31A 2iyfB-4o1mA:
5.5		 2iyfB-4o1mA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 4 GLY A 104
GLU A 109
ASP A  80
TYR A  99
 None
None
NAD  A 401 (-3.6A)
None
 1.47A 2yvlC-4o1mA:
6.2		 2yvlC-4o1mA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 8 ALA A 224
TYR A  23
ILE A 222
HIS A 126
 NAD  A 401 (-4.0A)
NAD  A 401 (-4.9A)
None
None
 1.02A 2zm8A-4o1mA:
undetectable		 2zm8A-4o1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 8 ALA A 224
TYR A  23
ILE A 222
HIS A 126
 NAD  A 401 (-4.0A)
NAD  A 401 (-4.9A)
None
None
 1.02A 2zmaA-4o1mA:
undetectable		 2zmaA-4o1mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 5 ALA A 255
LEU A 261
GLY A 225
THR A 285
 None
 0.95A 3dl9A-4o1mA:
undetectable		 3dl9A-4o1mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 8 THR A 141
LEU A 138
SER A 194
ASN A 130
 None
 0.92A 3kp2A-4o1mA:
undetectable
3kp2B-4o1mA:
undetectable		 3kp2A-4o1mA:
19.56
3kp2B-4o1mA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 8 THR A 141
LEU A 138
SER A 194
ASN A 152
 None
 1.11A 3kp2A-4o1mA:
undetectable
3kp2B-4o1mA:
undetectable		 3kp2A-4o1mA:
19.56
3kp2B-4o1mA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.88A 3pghC-4o1mA:
undetectable		 3pghC-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.88A 3pghD-4o1mA:
undetectable		 3pghD-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.90A 4coxC-4o1mA:
undetectable		 4coxC-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 PHE A 157
TYR A  23
ALA A 269
GLY A 267
LEU A 271
 None
NAD  A 401 (-4.9A)
None
None
None
 1.47A 4oadA-4o1mA:
undetectable		 4oadA-4o1mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.94A 4otyA-4o1mA:
undetectable		 4otyA-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.91A 4otyB-4o1mA:
undetectable		 4otyB-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.99A 4rrwD-4o1mA:
undetectable		 4rrwD-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.99A 4rrzD-4o1mA:
undetectable		 4rrzD-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 5 GLY A 225
TYR A 250
SER A 251
ASP A 289
 None
 1.24A 4xueA-4o1mA:
6.7		 4xueA-4o1mA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 GLY A 225
TYR A 250
SER A 251
ASP A 289
ALA A 224
 None
None
None
None
NAD  A 401 (-4.0A)
 1.22A 4ymgB-4o1mA:
6.0		 4ymgB-4o1mA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.87A 5ikqA-4o1mA:
undetectable		 5ikqA-4o1mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.87A 5ikqB-4o1mA:
undetectable		 5ikqB-4o1mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.99A 5jvzA-4o1mA:
undetectable		 5jvzA-4o1mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.80A 5jw1B-4o1mA:
undetectable		 5jw1B-4o1mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.81A 5kirA-4o1mA:
undetectable		 5kirA-4o1mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 ALA A 111
VAL A 114
GLY A  41
TRP A  43
ALA A  18
 None
None
None
NAD  A 401 (-4.8A)
NAD  A 401 (-3.7A)
 1.20A 5n5dA-4o1mA:
3.1		 5n5dA-4o1mA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		4 / 5 HIS A 126
ALA A  81
SER A 156
TYR A 155
 None
NAD  A 401 (-3.7A)
None
None
 1.25A 5yodF-4o1mA:
undetectable		 5yodF-4o1mA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4o1m ENOYL-ACYL CARRIER
REDUCTASE
(Toxoplasma
gondii) 		5 / 12 LEU A 128
GLY A  16
VAL A 125
LEU A 124
ILE A 123
 NAD  A 401 (-4.0A)
NAD  A 401 (-3.9A)
None
None
None
 0.99A 6ectA-4o1mA:
4.8		 6ectA-4o1mA:
22.25