SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.21A 1a52A-4o1oA:
undetectable		 1a52A-4o1oA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.21A 1a52B-4o1oA:
undetectable		 1a52B-4o1oA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 9 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.20A 1ereA-4o1oA:
undetectable		 1ereA-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 9 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.19A 1ereB-4o1oA:
undetectable		 1ereB-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 9 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.19A 1ereC-4o1oA:
undetectable		 1ereC-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 9 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.19A 1ereD-4o1oA:
undetectable		 1ereD-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.24A 1g50B-4o1oA:
undetectable		 1g50B-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 11 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.23A 1g50C-4o1oA:
undetectable		 1g50C-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.19A 1pcgA-4o1oA:
undetectable		 1pcgA-4o1oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.20A 1qkuA-4o1oA:
undetectable		 1qkuA-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.21A 1qkuB-4o1oA:
undetectable		 1qkuB-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.20A 1qkuC-4o1oA:
undetectable		 1qkuC-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 388
LEU A 406
CYH A 435
LEU A 473
HIS A 480
 None
 0.57A 1uwhA-4o1oA:
16.0		 1uwhA-4o1oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		6 / 12 ALA A 388
LYS A 390
LEU A 406
CYH A 435
LEU A 473
HIS A 480
 None
 0.81A 1uwhB-4o1oA:
15.9		 1uwhB-4o1oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 ALA A 126
PHE A 127
ALA A 131
LEU A 185
LEU A 106
 None
 1.13A 2bxqA-4o1oA:
2.4		 2bxqA-4o1oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 7 ALA A 167
GLY A 166
GLY A 165
ASN A 198
PHE A 124
 25L  A1000 ( 4.4A)
None
25L  A1000 ( 4.3A)
None
25L  A1000 (-3.5A)
 1.12A 2c49B-4o1oA:
undetectable		 2c49B-4o1oA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.16A 2h77A-4o1oA:
undetectable		 2h77A-4o1oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.22A 2j7xA-4o1oA:
undetectable		 2j7xA-4o1oA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 PHE A 673
LYS A 632
MET A 689
ILE A 693
PHE A 700
 None
 1.06A 2lbdA-4o1oA:
undetectable		 2lbdA-4o1oA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 715
LEU A 593
ILE A 602
GLY A 668
LEU A 667
 None
 1.07A 2ouzA-4o1oA:
undetectable		 2ouzA-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 4 LEU A 241
PRO A 240
LEU A 256
ARG A 293
 None
 1.39A 2qd2A-4o1oA:
undetectable		 2qd2A-4o1oA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		3 / 3 SER A 476
TYR A 478
HIS A 474
 None
 0.67A 2r2vD-4o1oA:
undetectable		 2r2vD-4o1oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 PHE A 127
ALA A 191
LEU A 170
ALA A 169
 None
 0.84A 2vcvP-4o1oA:
undetectable		 2vcvP-4o1oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 204
LEU A 224
ALA A 216
ASN A 249
PRO A 240
 None
 1.03A 2vmyA-4o1oA:
undetectable		 2vmyA-4o1oA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ILE A 369
ALA A 499
THR A 438
LEU A 473
PHE A 501
 None
 1.08A 2y7hC-4o1oA:
2.4		 2y7hC-4o1oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.21A 2yjaB-4o1oA:
undetectable		 2yjaB-4o1oA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		6 / 10 ALA A 388
LYS A 390
VAL A 416
LEU A 432
LEU A 434
LEU A 489
 None
 0.59A 3aoxA-4o1oA:
16.3		 3aoxA-4o1oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 HIS A 178
GLY A 134
TYR A 133
ARG A 135
 None
None
25L  A1000 (-4.7A)
None
 1.16A 3ccfA-4o1oA:
undetectable		 3ccfA-4o1oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 HIS A 474
LEU A 466
LEU A 578
GLY A 522
LEU A 559
 None
 1.10A 3n8xB-4o1oA:
undetectable		 3n8xB-4o1oA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 ARG A 516
LEU A 473
LEU A 483
LEU A 518
ILE A 470
 None
 1.13A 3wdmD-4o1oA:
undetectable		 3wdmD-4o1oA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 VAL A 415
VAL A 416
CYH A 435
LEU A 489
 None
 0.58A 3wzeA-4o1oA:
16.8		 3wzeA-4o1oA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ASP A 482
PHE A 536
LEU A 524
LYS A 540
 None
 0.94A 4f8hA-4o1oA:
undetectable
4f8hB-4o1oA:
undetectable		 4f8hA-4o1oA:
18.53
4f8hB-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ASP A 482
PHE A 536
LEU A 524
LYS A 540
 None
 0.97A 4f8hB-4o1oA:
undetectable
4f8hC-4o1oA:
2.7		 4f8hB-4o1oA:
18.53
4f8hC-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ASP A 482
PHE A 536
LEU A 524
LYS A 540
 None
 0.94A 4f8hC-4o1oA:
2.7
4f8hD-4o1oA:
undetectable		 4f8hC-4o1oA:
18.53
4f8hD-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ASP A 482
PHE A 536
LEU A 524
LYS A 540
 None
 0.93A 4f8hD-4o1oA:
undetectable
4f8hE-4o1oA:
undetectable		 4f8hD-4o1oA:
18.53
4f8hE-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 PHE A 536
LEU A 524
LYS A 540
ASP A 482
 None
 0.94A 4f8hA-4o1oA:
undetectable
4f8hE-4o1oA:
undetectable		 4f8hA-4o1oA:
18.53
4f8hE-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 7 GLY A 375
GLY A 376
TYR A 378
GLU A 374
 None
 1.11A 4fgkB-4o1oA:
undetectable		 4fgkB-4o1oA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.16A 4j24A-4o1oA:
undetectable		 4j24A-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.15A 4j24C-4o1oA:
undetectable		 4j24C-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.14A 4j26A-4o1oA:
undetectable		 4j26A-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.14A 4j26B-4o1oA:
undetectable		 4j26B-4o1oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.13A 4lnwA-4o1oA:
undetectable		 4lnwA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.12A 4lnxA-4o1oA:
undetectable		 4lnxA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 7 ALA A 388
CYH A 435
ASN A 487
LEU A 489
ASP A 500
 None
 0.64A 4ogrE-4o1oA:
16.9		 4ogrE-4o1oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		6 / 9 ILE A 369
ALA A 388
CYH A 435
ASN A 487
LEU A 489
ASP A 500
 None
 0.85A 4ogrI-4o1oA:
11.2		 4ogrI-4o1oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 LEU A 108
LEU A  61
HIS A  62
ILE A  95
 None
 1.03A 4ok1A-4o1oA:
undetectable		 4ok1A-4o1oA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ILE A  99
ILE A  96
ALA A  91
LYS A  87
 None
None
None
25L  A1000 (-3.5A)
 0.80A 4ou1A-4o1oA:
undetectable		 4ou1A-4o1oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 11 ILE A 219
LEU A 204
HIS A 226
LEU A 224
ALA A 228
 None
 1.08A 4p65E-4o1oA:
undetectable
4p65F-4o1oA:
undetectable
4p65J-4o1oA:
undetectable
4p65L-4o1oA:
undetectable		 4p65E-4o1oA:
2.24
4p65F-4o1oA:
3.84
4p65J-4o1oA:
3.84
4p65L-4o1oA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 10 ILE A 369
ALA A 388
LYS A 390
LEU A 434
LEU A 489
 None
 0.88A 4rz7A-4o1oA:
15.2		 4rz7A-4o1oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		6 / 12 ALA A 388
LYS A 390
LEU A 406
CYH A 435
HIS A 480
LEU A 489
 None
 0.58A 4u0iA-4o1oA:
16.8		 4u0iA-4o1oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 7 GLU A 258
LEU A 256
ASN A 249
LEU A 208
 None
 0.73A 4wg0B-4o1oA:
undetectable
4wg0C-4o1oA:
undetectable		 4wg0B-4o1oA:
2.62
4wg0C-4o1oA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 7 ASN A 249
LEU A 208
GLU A 258
LEU A 256
 None
 0.82A 4wg0L-4o1oA:
undetectable
4wg0M-4o1oA:
undetectable		 4wg0L-4o1oA:
2.62
4wg0M-4o1oA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 388
LYS A 390
CYH A 435
ASP A 500
PHE A 501
 None
 0.85A 4xv2B-4o1oA:
16.1		 4xv2B-4o1oA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 388
LYS A 390
LEU A 406
CYH A 435
PHE A 501
 None
 0.78A 4xv2B-4o1oA:
16.1		 4xv2B-4o1oA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 11 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.19A 5dxbB-4o1oA:
undetectable		 5dxbB-4o1oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ALA A 207
PRO A 240
LEU A 252
LEU A 256
 None
 0.97A 5dzkF-4o1oA:
undetectable
5dzkT-4o1oA:
undetectable		 5dzkF-4o1oA:
15.46
5dzkT-4o1oA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 6 ASP A 120
ASP A 197
ASN A 122
GLN A 159
 25L  A1000 ( 4.4A)
None
25L  A1000 (-3.3A)
None
 1.06A 5l6eA-4o1oA:
undetectable		 5l6eA-4o1oA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 5 LEU A 406
CYH A 435
LEU A 489
ASP A 500
 None
 0.87A 5mafA-4o1oA:
18.1		 5mafA-4o1oA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 388
VAL A 416
HIS A 480
LEU A 489
ALA A 499
 None
 0.80A 5mo4A-4o1oA:
13.4		 5mo4A-4o1oA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ALA A 388
CYH A 435
LEU A 489
ASP A 500
 None
 0.61A 5owrA-4o1oA:
15.9		 5owrA-4o1oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.13A 5toaB-4o1oA:
undetectable		 5toaB-4o1oA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 4 VAL A 416
LEU A 434
ASN A 487
ASP A 500
 None
 0.96A 5vcyA-4o1oA:
16.9		 5vcyA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 5 LEU A 314
LEU A 283
ALA A 287
LEU A 290
 None
 0.83A 5vkqB-4o1oA:
12.7
5vkqC-4o1oA:
18.8		 5vkqB-4o1oA:
18.44
5vkqC-4o1oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 MET A 638
GLU A 679
LEU A 677
ILE A 674
TRP A 629
 None
 1.33A 5vlmE-4o1oA:
2.2		 5vlmE-4o1oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 LEU A 109
VAL A  65
PRO A  93
THR A  92
GLU A 118
 None
 1.40A 5xipD-4o1oA:
undetectable		 5xipD-4o1oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 5 GLU A  70
ASN A 102
VAL A 103
ARG A 104
 None
 1.49A 6aggZ-4o1oA:
undetectable		 6aggZ-4o1oA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 7 ILE A 488
LEU A 498
LEU A 483
LEU A 574
 None
 0.64A 6g9bA-4o1oA:
undetectable
6g9bB-4o1oA:
undetectable		 6g9bA-4o1oA:
9.60
6g9bB-4o1oA:
9.63