SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.28A 1hrkB-4o1sA:
undetectable		 1hrkB-4o1sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 11 VAL A 134
ILE A 137
LEU A 113
LEU A 165
LEU A  97
 None
 1.25A 2a15A-4o1sA:
undetectable		 2a15A-4o1sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.24A 2po7B-4o1sA:
undetectable		 2po7B-4o1sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.33A 3aqiB-4o1sA:
undetectable		 3aqiB-4o1sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.33A 3w1wA-4o1sA:
undetectable		 3w1wA-4o1sA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.32A 3w1wB-4o1sA:
undetectable		 3w1wB-4o1sA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 VAL A 122
TYR A  55
TYR A  57
ILE A  22
ILE A  20
 None
None
SO4  A 203 (-4.3A)
None
None
 1.42A 4xucA-4o1sA:
undetectable		 4xucA-4o1sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		5 / 12 VAL A 122
TYR A  55
TYR A  57
ILE A  22
ILE A  20
 None
None
SO4  A 203 (-4.3A)
None
None
 1.43A 4xudA-4o1sA:
undetectable		 4xudA-4o1sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Thermoplasma
volcanium) 		4 / 6 VAL A  58
VAL A 151
SER A  65
ILE A  52
 None
 1.08A 5jw1B-4o1sA:
undetectable		 5jw1B-4o1sA:
15.65