SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 9 MET A 378
PHE A 382
ARG A 388
LEU A 385
GLY A 383
 None
None
SO4  A 602 (-3.2A)
None
None
 1.48A 1jb0A-4o26A:
undetectable		 1jb0A-4o26A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 10 LEU A 462
ALA A 526
VAL A 458
LEU A 436
PHE A 542
 None
 1.28A 1rlbE-4o26A:
undetectable		 1rlbE-4o26A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 5 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.33A 3bjwE-4o26A:
undetectable		 3bjwE-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 5 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.23A 3bjwH-4o26A:
undetectable		 3bjwH-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 6 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.19A 3bjwF-4o26A:
undetectable		 3bjwF-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 5 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.38A 3bjwB-4o26A:
undetectable		 3bjwB-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		3 / 3 THR A 337
GLU A 564
HIS A 559
 None
None
SO4  A 605 (-3.7A)
 0.82A 3g1uB-4o26A:
undetectable		 3g1uB-4o26A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 12 TYR A 394
LEU A 436
PHE A 431
MET A 326
ALA A 526
 None
None
None
SO4  A 608 (-4.8A)
None
 1.37A 3nuvA-4o26A:
undetectable		 3nuvA-4o26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 10 TYR A 394
LEU A 436
PHE A 431
MET A 326
ALA A 526
 None
None
None
SO4  A 608 (-4.8A)
None
 1.25A 3nuvB-4o26A:
undetectable		 3nuvB-4o26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 10 TYR A 394
LEU A 436
PHE A 431
VAL A 432
ALA A 526
 None
 1.18A 3nuvB-4o26A:
undetectable		 3nuvB-4o26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 9 MET A 378
PHE A 382
ARG A 388
LEU A 385
GLY A 383
 None
None
SO4  A 602 (-3.2A)
None
None
 1.48A 3pcqA-4o26A:
undetectable		 3pcqA-4o26A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		3 / 3 TYR A 543
HIS A 422
ARG A 541
 None
 1.09A 4e7bC-4o26A:
undetectable		 4e7bC-4o26A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 7 PHE A 461
LEU A 462
VAL A 521
PHE A 519
 None
 1.07A 4wnvD-4o26A:
undetectable		 4wnvD-4o26A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		5 / 9 LEU A 523
ARG A 433
PHE A 454
THR A 513
ASP A 517
 None
SO4  A 607 (-3.8A)
None
None
None
 1.28A 5gpgB-4o26A:
0.0		 5gpgB-4o26A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 6 VAL A 439
HIS A 389
CYH A 435
LEU A 523
 None
 1.03A 5hrqB-4o26A:
undetectable
5hrqI-4o26A:
undetectable
5hrqJ-4o26A:
undetectable		 5hrqB-4o26A:
8.27
5hrqI-4o26A:
5.65
5hrqJ-4o26A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4o26 TELOMERASE REVERSE
TRANSCRIPTASE
(Oryzias
latipes) 		4 / 6 VAL A 439
HIS A 389
CYH A 435
LEU A 523
 None
 1.10A 5hrqH-4o26A:
undetectable
5hrqK-4o26A:
undetectable
5hrqL-4o26A:
undetectable		 5hrqH-4o26A:
8.27
5hrqK-4o26A:
5.65
5hrqL-4o26A:
8.27