SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 5 THR A 122
GLU A 118
THR A 114
LEU A 156
 None
 1.26A 1d4fC-4o27A:
undetectable		 1d4fC-4o27A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		5 / 9 LEU A  54
ILE A  53
LEU A  83
VAL A  16
LEU A  74
 None
 1.03A 1e7aB-4o27A:
undetectable		 1e7aB-4o27A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 8 TYR A 214
PHE A 210
THR A 193
LEU A 236
 None
 1.19A 1ea1A-4o27A:
undetectable		 1ea1A-4o27A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		5 / 10 LEU A 218
VAL A 277
TYR A 214
GLY A 234
LEU A 258
 None
 1.41A 1fkoA-4o27A:
undetectable		 1fkoA-4o27A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 5 LEU B 102
GLY B 105
LYS B  40
TYR B 101
 ADP  B 500 (-4.3A)
None
None
ADP  B 500 ( 4.7A)
 1.36A 1gtiF-4o27B:
undetectable		 1gtiF-4o27B:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.93A 1iepA-4o27B:
18.4		 1iepA-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 104
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 1.13A 1iepB-4o27B:
18.3		 1iepB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.98A 1iepB-4o27B:
18.3		 1iepB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
 None
 1.34A 1l7fA-4o27B:
undetectable		 1l7fA-4o27B:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
 None
 1.32A 1l7hA-4o27B:
undetectable		 1l7hA-4o27B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.87A 1opjB-4o27B:
17.8		 1opjB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 4 THR B  83
GLY B 105
ASP B 109
ALA B 148
 ADP  B 500 ( 4.9A)
None
None
None
 1.22A 1sg9A-4o27B:
undetectable		 1sg9A-4o27B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 ASP B 162
GLY B 164
ILE B 145
GLY B 181
ALA B 148
 ADP  B 500 ( 3.4A)
None
None
None
None
 1.07A 1sh9B-4o27B:
undetectable		 1sh9B-4o27B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B  74
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.73A 1t46A-4o27B:
24.3		 1t46A-4o27B:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
None
None
None
None
 0.57A 1uwhA-4o27B:
15.8		 1uwhA-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.58A 1uwhB-4o27B:
15.6		 1uwhB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
 0.45A 1uwjA-4o27B:
7.5		 1uwjA-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
 0.45A 1uwjB-4o27B:
7.5		 1uwjB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4o27 CALCIUM-BINDING
PROTEIN 39
SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B  66
GLU A 235
ARG A 313
 None
 0.74A 1wopA-4o27B:
undetectable		 1wopA-4o27B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 7 PHE A 169
PHE A 210
LEU A 236
PHE A 166
 None
 1.10A 1wrlE-4o27A:
undetectable		 1wrlE-4o27A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		5 / 12 GLN A 165
LEU A 131
VAL A 117
CYH A 150
HIS A 153
 None
 1.06A 1xiuB-4o27A:
undetectable		 1xiuB-4o27A:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 11 GLY B  31
GLY B  33
VAL B  38
ALA B  51
MET B  99
TYR B 101
SER B 106
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-3.4A)
ADP  B 500 (-4.7A)
 0.76A 2evaA-4o27B:
19.2		 2evaA-4o27B:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
MET B  99
TYR B 101
LYS B 146
ASN B 149
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
MN  B 501 ( 3.1A)
 0.81A 2fumB-4o27B:
21.0		 2fumB-4o27B:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.92A 2hyyA-4o27B:
18.5		 2hyyA-4o27B:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
 0.74A 2hyyB-4o27B:
18.5		 2hyyB-4o27B:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.89A 2hyyC-4o27B:
18.4		 2hyyC-4o27B:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.95A 2hyyD-4o27B:
18.3		 2hyyD-4o27B:
29.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.86A 2oiqA-4o27B:
19.0		 2oiqA-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.77A 2oiqA-4o27B:
19.0		 2oiqA-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.96A 2pl0A-4o27B:
18.9		 2pl0A-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 ( 3.4A)
 0.76A 2pl0A-4o27B:
18.9		 2pl0A-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
 0.68A 2pl0A-4o27B:
18.9		 2pl0A-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 LEU B 255
ILE B 210
ARG B 214
PRO B 232
VAL B 227
 None
 1.49A 2qd4B-4o27B:
undetectable		 2qd4B-4o27B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 9 ARG B 290
LEU B 125
ALA B 147
GLY B 156
LEU B 152
 None
 1.04A 2v0mB-4o27B:
undetectable		 2v0mB-4o27B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
TYR B 101
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.83A 2wgjA-4o27B:
20.7		 2wgjA-4o27B:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.66A 2y6oA-4o27B:
19.5		 2y6oA-4o27B:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
GLU B  70
GLY B 105
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.85A 3cs9A-4o27B:
18.1		 3cs9A-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
GLU B  70
VAL B  73
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.84A 3cs9A-4o27B:
18.1		 3cs9A-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
GLY B 105
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.72A 3cs9B-4o27B:
19.1		 3cs9B-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
VAL B  73
GLY B 105
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.69A 3cs9B-4o27B:
19.1		 3cs9B-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
VAL B  73
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.92A 3cs9C-4o27B:
24.0		 3cs9C-4o27B:
29.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 GLY B  31
GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
MET B  99
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 (-4.7A)
 0.60A 3eygA-4o27B:
20.0		 3eygA-4o27B:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 GLY B  31
GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
MET B  99
SER B 106
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 (-3.4A)
 0.61A 3eygA-4o27B:
20.0		 3eygA-4o27B:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		9 / 12 GLY B  31
GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
MET B  99
TYR B 101
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
 0.75A 3fupA-4o27B:
27.7		 3fupA-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 GLY B  31
GLY B  33
VAL B  38
ALA B  51
LYS B  53
MET B  99
TYR B 101
SER B 106
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-3.4A)
 0.79A 3fupA-4o27B:
27.7		 3fupA-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
GLY B  33
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
 0.55A 3fupB-4o27B:
27.7		 3fupB-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
ADP  B 500 (-4.7A)
 0.53A 3fupB-4o27B:
27.7		 3fupB-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
 0.43A 3g5dA-4o27B:
20.3		 3g5dA-4o27B:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.66A 3g5dB-4o27B:
20.3		 3g5dB-4o27B:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.60A 3k54A-4o27B:
19.8		 3k54A-4o27B:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
 0.71A 3k5vA-4o27B:
17.7		 3k5vA-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.92A 3k5vB-4o27B:
17.7		 3k5vB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		3 / 3 ALA B 122
ARG B 126
LYS B 130
 None
 1.02A 3kp3B-4o27B:
undetectable		 3kp3B-4o27B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		3 / 3 ALA B 122
ARG B 126
LYS B 130
 None
 0.91A 3kp5B-4o27B:
undetectable		 3kp5B-4o27B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
LYS B  53
MET B  99
TYR B 101
ALA B 161
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
 0.76A 3lxkA-4o27B:
27.6		 3lxkA-4o27B:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
GLY B  33
VAL B  38
ALA B  51
LYS B  53
TYR B 101
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
 0.60A 3lxnA-4o27B:
27.7		 3lxnA-4o27B:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
GLY B  33
VAL B  38
ALA B  51
LYS B  53
TYR B 101
SER B 106
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-3.4A)
 0.61A 3lxnA-4o27B:
27.7		 3lxnA-4o27B:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.93A 3ms9A-4o27B:
18.3		 3ms9A-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.92A 3ms9B-4o27B:
18.3		 3ms9B-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.95A 3mssA-4o27B:
18.4		 3mssA-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
 0.71A 3mssB-4o27B:
24.2		 3mssB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 6 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
 0.65A 3mssD-4o27B:
18.4		 3mssD-4o27B:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
GLU B  70
VAL B  73
ILE B  97
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 1.01A 3oezB-4o27B:
19.0		 3oezB-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		9 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
VAL B  73
ILE B  97
TYR B 101
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
 0.75A 3oezB-4o27B:
19.0		 3oezB-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 GLY B  31
VAL B  38
ALA B  51
LYS B  53
LEU B  74
GLY B 103
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
 0.73A 3ohtB-4o27B:
5.9		 3ohtB-4o27B:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B 161
THR B 208
LEU B 212
ILE B 128
THR B  83
 None
None
None
None
ADP  B 500 ( 4.9A)
 1.17A 3qfxA-4o27B:
undetectable		 3qfxA-4o27B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B 161
THR B 208
LEU B 212
ILE B 128
THR B  83
 None
None
None
None
ADP  B 500 ( 4.9A)
 1.18A 3qfxB-4o27B:
undetectable		 3qfxB-4o27B:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.72A 3qlgA-4o27B:
25.9		 3qlgA-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.62A 3qlgB-4o27B:
20.0		 3qlgB-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B  74
TYR B 101
LEU B 135
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
None
 0.71A 3rgfA-4o27B:
19.5		 3rgfA-4o27B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
None
 0.66A 3rgfA-4o27B:
19.5		 3rgfA-4o27B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
LEU B 151
 ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
 0.65A 3v5wA-4o27B:
10.1		 3v5wA-4o27B:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
GLY B 105
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.75A 3wzeA-4o27B:
17.7		 3wzeA-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B 135
HIS B 142
ARG B 143
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
 0.71A 3zosA-4o27B:
17.3		 3zosA-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B 135
HIS B 142
ARG B 143
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
 0.78A 3zosB-4o27B:
23.9		 3zosB-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B  74
GLY B 105
LEU B 151
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
 0.75A 4agcA-4o27B:
17.1		 4agcA-4o27B:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 9 VAL B  38
ALA B  51
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.73A 4anqA-4o27B:
18.2		 4anqA-4o27B:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 9 VAL B  38
ALA B  51
MET B  99
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.59A 4ansA-4o27B:
18.2		 4ansA-4o27B:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 1.05A 4bkjA-4o27B:
19.5		 4bkjA-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.96A 4bkjB-4o27B:
19.4		 4bkjB-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		9 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B  74
ILE B  97
HIS B 142
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.82A 4c8bA-4o27B:
25.1		 4c8bA-4o27B:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B  74
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.63A 4c8bB-4o27B:
24.8		 4c8bB-4o27B:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
LEU B  74
HIS B 142
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.84A 4c8bB-4o27B:
24.8		 4c8bB-4o27B:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.85A 4csvA-4o27B:
19.6		 4csvA-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 4 LEU B 247
ALA B 122
ILE B 121
LYS B 248
 None
 1.29A 4eixA-4o27B:
undetectable		 4eixA-4o27B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
ASP B 144
LYS B 146
ASN B 149
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
MN  B 501 ( 3.1A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.73A 4i41A-4o27B:
22.2		 4i41A-4o27B:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 ALA B 161
THR B 208
LEU B 212
ILE B 128
THR B  83
 None
None
None
None
ADP  B 500 ( 4.9A)
 1.05A 4km0A-4o27B:
undetectable		 4km0A-4o27B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B 161
THR B 208
LEU B 212
ILE B 128
THR B  83
 None
None
None
None
ADP  B 500 ( 4.9A)
 1.03A 4km0B-4o27B:
undetectable		 4km0B-4o27B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 8 TYR A 119
LEU A  74
TYR A  75
VAL A  16
 None
 0.91A 4l1xA-4o27A:
undetectable		 4l1xA-4o27A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 8 ASP B  66
GLU B 178
VAL B  73
THR B  72
 None
 1.14A 4lnwA-4o27B:
undetectable		 4lnwA-4o27B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
 None
 1.36A 4mwvA-4o27B:
undetectable		 4mwvA-4o27B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 8 GLY B 103
GLY B 156
LEU B 284
LEU B 287
 None
 0.76A 4mwzB-4o27B:
undetectable		 4mwzB-4o27B:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 ( 3.4A)
 0.65A 4mxoA-4o27B:
20.4		 4mxoA-4o27B:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.82A 4mxoB-4o27B:
20.4		 4mxoB-4o27B:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.82A 4mxxA-4o27B:
20.3		 4mxxA-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
GLU B  70
ILE B  97
MET B  99
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxyA-4o27B:
22.9		 4mxyA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxyA-4o27B:
22.9		 4mxyA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.89A 4mxyA-4o27B:
22.9		 4mxyA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
TYR B 101
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.85A 4mxyB-4o27B:
23.1		 4mxyB-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
GLU B  70
ILE B  97
MET B  99
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.87A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.89A 4mxzA-4o27B:
22.9		 4mxzA-4o27B:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
TYR B 101
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.85A 4mxzB-4o27B:
23.1		 4mxzB-4o27B:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 6 GLY B  31
VAL B  38
ALA B  51
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.7A)
 0.23A 4o0wA-4o27B:
24.3		 4o0wA-4o27B:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLY B  31
GLY B  33
GLY B  36
VAL B  38
ALA B  51
LEU B 151
ALA B 161
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.7A)
None
 0.54A 4otiA-4o27B:
18.0		 4otiA-4o27B:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
LYS B  53
GLU B  70
THR B  83
ILE B  97
MET B  99
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.9A)
None
ADP  B 500 ( 4.1A)
None
ADP  B 500 ( 3.4A)
 0.96A 4qmnA-4o27B:
33.8		 4qmnA-4o27B:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		9 / 12 ALA B  51
LYS B  53
GLU B  70
THR B  83
ILE B  97
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.9A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.67A 4qmnA-4o27B:
33.8		 4qmnA-4o27B:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 11 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 102
LEU B 151
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.70A 4qmsA-4o27B:
33.7		 4qmsA-4o27B:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		11 / 12 GLY B  31
VAL B  38
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
TYR B 291
LYS B 295
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.9A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
None
ADP  B 500 (-4.7A)
None
None
 0.64A 4qmzA-4o27B:
33.5		 4qmzA-4o27B:
94.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
LEU B 135
ARG B 143
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.82A 4qrcA-4o27B:
19.9		 4qrcA-4o27B:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.57A 4r7iA-4o27B:
19.1		 4r7iA-4o27B:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
LYS B  53
ILE B  97
SER B 106
PHE B 163
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 (-3.4A)
None
 0.77A 4rzvA-4o27B:
7.5		 4rzvA-4o27B:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 VAL B  38
ALA B  51
LYS B  53
SER B 106
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-3.4A)
None
 0.85A 4rzvB-4o27B:
24.0		 4rzvB-4o27B:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4o27 CALCIUM-BINDING
PROTEIN 39
SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 7 GLU B  61
GLU B  58
TYR A 223
LEU B  90
 None
 1.10A 4twdF-4o27B:
undetectable
4twdJ-4o27B:
undetectable		 4twdF-4o27B:
19.55
4twdJ-4o27B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLY B 105
ASN B 149
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
MN  B 501 ( 3.1A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.66A 4twpA-4o27B:
21.0		 4twpA-4o27B:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
GLU B  70
HIS B 142
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.99A 4tyjA-4o27B:
20.4		 4tyjA-4o27B:
28.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		9 / 11 GLY B  33
VAL B  38
ALA B  51
TYR B 101
GLY B 105
ASN B 149
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.7A)
None
MN  B 501 ( 3.1A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.60A 4u5jA-4o27B:
20.5		 4u5jA-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
LEU B 135
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
 0.58A 4uxqA-4o27B:
20.0		 4uxqA-4o27B:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.60A 4v01A-4o27B:
18.6		 4v01A-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.54A 4v01B-4o27B:
18.8		 4v01B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
HIS B 142
ALA B 161
GLY B 164
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
None
 1.24A 4v04A-4o27B:
24.2		 4v04A-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
None
 0.60A 4v04A-4o27B:
24.2		 4v04A-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
GLU B  70
HIS B 142
ALA B 161
ASP B 162
GLY B 164
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
None
 1.36A 4v04B-4o27B:
20.1		 4v04B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 12 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.64A 4v04B-4o27B:
20.1		 4v04B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		3 / 3 ASP B 197
ARG B 262
PRO B 259
 None
 0.96A 4wanC-4o27B:
undetectable		 4wanC-4o27B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  97
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 (-4.7A)
None
 0.79A 4xeyA-4o27B:
22.4		 4xeyA-4o27B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 6 LEU A 192
ASP A 239
GLU A 235
ILE A 151
 None
 0.95A 4xi3C-4o27A:
undetectable		 4xi3C-4o27A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.55A 4xliB-4o27B:
23.6		 4xliB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.67A 5bvwA-4o27B:
19.4		 5bvwA-4o27B:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
ILE B  97
TYR B 101
ASP B 109
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
 0.85A 5hesA-4o27B:
24.3		 5hesA-4o27B:
30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  97
TYR B 101
ASP B 109
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
None
 0.76A 5hesB-4o27B:
20.2		 5hesB-4o27B:
30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  97
TYR B 101
PHE B 163
GLY B 164
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
None
 0.89A 5hesB-4o27B:
20.2		 5hesB-4o27B:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 ALA B  51
LYS B  53
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.59A 5hi2A-4o27B:
16.4		 5hi2A-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens) 		4 / 4 ASN A  46
LEU A  19
SER A  44
LEU A  26
 None
 1.33A 5kb5A-4o27A:
undetectable		 5kb5A-4o27A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		8 / 12 GLU B  28
GLY B  31
VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
 None
ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
 0.83A 5mafA-4o27B:
29.2		 5mafA-4o27B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 VAL B  38
LYS B  53
GLU B  70
ILE B  97
GLY B 103
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
None
 0.57A 5mo4A-4o27B:
17.5		 5mo4A-4o27B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 7 ILE B  52
PHE B  39
TRP B  96
LYS B  94
 None
 1.46A 5nr3A-4o27B:
undetectable		 5nr3A-4o27B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		4 / 7 LEU B 247
ALA B 213
ILE B 124
LEU B 125
 None
 0.81A 5te8A-4o27B:
undetectable		 5te8A-4o27B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLU B  28
ALA B  51
GLU B  70
TYR B 101
GLY B 105
ASP B 109
ASP B 162
 None
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.90A 5vc3A-4o27B:
27.2		 5vc3A-4o27B:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 GLU B  28
GLY B  31
ALA B  51
TYR B 101
GLY B 105
ASP B 109
ASP B 162
 None
ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.95A 5vc3A-4o27B:
27.2		 5vc3A-4o27B:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 ILE B 124
ILE B 121
LEU B 247
HIS B 142
ILE B 145
 None
 1.24A 5vkqA-4o27B:
undetectable
5vkqD-4o27B:
undetectable		 5vkqA-4o27B:
10.11
5vkqD-4o27B:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 HIS B 142
ILE B 145
ILE B 124
ILE B 121
LEU B 247
 None
 1.23A 5vkqA-4o27B:
undetectable
5vkqB-4o27B:
undetectable		 5vkqA-4o27B:
10.11
5vkqB-4o27B:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 HIS B 142
ILE B 145
ILE B 124
ILE B 121
LEU B 247
 None
 1.23A 5vkqC-4o27B:
undetectable
5vkqD-4o27B:
undetectable		 5vkqC-4o27B:
10.11
5vkqD-4o27B:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 LEU B 284
ILE B 128
LEU B 129
LEU B 275
ALA B 278
 None
 1.17A 5y7pB-4o27B:
undetectable		 5y7pB-4o27B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 LEU B 284
ILE B 128
LEU B 129
LEU B 275
ALA B 278
 None
 1.19A 5y7pD-4o27B:
undetectable		 5y7pD-4o27B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		5 / 10 LEU B 284
ILE B 128
LEU B 129
LEU B 275
ALA B 278
 None
 1.24A 5y7pH-4o27B:
undetectable		 5y7pH-4o27B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
GLU B  70
TYR B 101
GLY B 105
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
 0.53A 5zv2A-4o27B:
20.1		 5zv2A-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		3 / 3 LYS B  53
LEU B 151
ASP B 162
 ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.94A 5zv2A-4o27B:
20.1		 5zv2A-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		6 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
GLY B 105
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
 0.50A 5zv2B-4o27B:
24.7		 5zv2B-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.62A 6bsdA-4o27B:
18.3		 6bsdA-4o27B:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.90A 6hd4B-4o27B:
17.5		 6hd4B-4o27B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
GLU B  70
ILE B  97
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.90A 6hd6A-4o27B:
17.7		 6hd6A-4o27B:
15.02