SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_A_FCNA4002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 10 HIS A 187
GLU A 184
ARG A 232
HIS A 183
THR A 206
 ZN  A 401 (-3.2A)
ZN  A 401 ( 4.1A)
None
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.6A)
 1.28A 1lqpA-4o2iA:
0.1
1lqpB-4o2iA:
0.0		 1lqpA-4o2iA:
16.05
1lqpB-4o2iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_B_FCNB4001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 10 HIS A 183
THR A 206
HIS A 187
GLU A 184
ARG A 232
 ZN  A 401 (-3.2A)
ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.1A)
None
 1.28A 1lqpA-4o2iA:
0.1
1lqpB-4o2iA:
0.0		 1lqpA-4o2iA:
16.05
1lqpB-4o2iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 9 HIS A 187
GLU A 184
ARG A 232
HIS A 183
THR A 206
 ZN  A 401 (-3.2A)
ZN  A 401 ( 4.1A)
None
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.6A)
 1.26A 1nkiA-4o2iA:
undetectable
1nkiB-4o2iA:
undetectable		 1nkiA-4o2iA:
16.05
1nkiB-4o2iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 9 HIS A 183
THR A 206
HIS A 187
GLU A 184
ARG A 232
 ZN  A 401 (-3.2A)
ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.1A)
None
 1.27A 1nkiA-4o2iA:
undetectable
1nkiB-4o2iA:
undetectable		 1nkiA-4o2iA:
16.05
1nkiB-4o2iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 11 ALA A 214
ILE A 185
VAL A 221
THR A 190
ALA A  93
 None
 0.98A 1rv7A-4o2iA:
undetectable
1rv7B-4o2iA:
undetectable		 1rv7A-4o2iA:
15.99
1rv7B-4o2iA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 11 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
 None
 0.94A 1z11A-4o2iA:
undetectable		 1z11A-4o2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 11 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
 None
 0.95A 1z11B-4o2iA:
undetectable		 1z11B-4o2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 12 LEU A 236
ASN A 240
ALA A 243
GLN A 246
SER A 171
 None
 1.24A 2aa5B-4o2iA:
undetectable		 2aa5B-4o2iA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 5 GLN A 178
THR A  79
ALA A  83
ARG A  86
 None
 1.44A 2qhfA-4o2iA:
undetectable		 2qhfA-4o2iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 8 LEU A  84
ASP A  92
GLU A  47
SER A  45
 None
 1.10A 2zw9A-4o2iA:
undetectable		 2zw9A-4o2iA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 9 VAL A 189
ILE A 105
PHE A  90
THR A  79
VAL A 161
 None
 1.18A 3me6C-4o2iA:
undetectable		 3me6C-4o2iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 11 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
 None
 1.01A 3t3rA-4o2iA:
undetectable		 3t3rA-4o2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 12 LEU A 236
ALA A 243
GLN A 246
SER A 171
PHE A 163
 None
 1.11A 4udaA-4o2iA:
undetectable		 4udaA-4o2iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 12 LEU A 236
ASN A 240
ALA A 243
GLN A 246
SER A 171
 None
 1.40A 4udaA-4o2iA:
undetectable		 4udaA-4o2iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 GLU A 143
PRO A 144
ILE A 145
LEU A 146
 None
 1.04A 5m45A-4o2iA:
undetectable		 5m45A-4o2iA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 GLU A 143
PRO A 144
ILE A 145
LEU A 146
 None
 1.07A 5m45D-4o2iA:
0.3		 5m45D-4o2iA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 GLU A 143
PRO A 144
ILE A 145
LEU A 146
 None
 1.03A 5m45G-4o2iA:
undetectable		 5m45G-4o2iA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 GLU A 143
PRO A 144
ILE A 145
LEU A 146
 None
 1.10A 5m45J-4o2iA:
undetectable		 5m45J-4o2iA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 12 GLY A 238
ASN A 240
GLU A 143
ASN A 242
TYR A 136
 None
 1.36A 5v37A-4o2iA:
undetectable		 5v37A-4o2iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		5 / 10 HIS A 183
THR A 206
HIS A 187
GLU A 184
ARG A 232
 ZN  A 401 (-3.2A)
ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.1A)
None
 1.27A 5v3dA-4o2iA:
undetectable
5v3dB-4o2iA:
undetectable		 5v3dA-4o2iA:
17.67
5v3dB-4o2iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 5 THR A 190
HIS A 187
ASP A 194
HIS A 183
 None
ZN  A 401 (-3.2A)
ZN  A 401 (-2.1A)
ZN  A 401 (-3.2A)
 1.29A 6dchA-4o2iA:
undetectable		 6dchA-4o2iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 ASP A 126
ILE A 145
PRO A 144
LEU A 116
 None
 1.47A 6mkeB-4o2iA:
undetectable		 6mkeB-4o2iA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 HIS A  71
LEU A 181
TYR A 110
GLY A  77
 None
 1.42A 6n91A-4o2iA:
undetectable		 6n91A-4o2iA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 4o2i NON-LEE ENCODED TYPE
III EFFECTOR C
(Citrobacter
rodentium) 		4 / 4 HIS A  71
LEU A 181
TYR A 110
GLY A  77
 None
 1.43A 6n91B-4o2iA:
undetectable		 6n91B-4o2iA:
16.94