SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q7L_A_TESA155_1 (ANDROGEN RECEPTOR)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	5 / 12	LEU A 83 LEU A 12 GLY A 13 GLN A 64 VAL A 98	None	1.40A	2q7lA-4o2lA: undetectable	2q7lA-4o2lA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CB8_A_SAMA501_0 (PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	5 / 12	SER A 68 LYS A 19 ARG A 15 VAL A 17 TYR A 85	None GTP A 201 ( 2.6A) None GTP A 201 (-4.1A) None	1.38A	3cb8A-4o2lA: 1.9	3cb8A-4o2lA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JTP_A_ASCA802_0 (RRNA N-GLYCOSIDASE)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	4 / 5	TYR A 81 ILE A 82 ASN A 79 ILE A 163	None	0.99A	4jtpA-4o2lA: undetectable	4jtpA-4o2lA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKT_A_198A1001_1 (ANDROGEN RECEPTOR)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	5 / 12	LEU A 83 LEU A 12 GLY A 13 GLN A 64 VAL A 98	None	1.40A	4oktA-4o2lA: undetectable	4oktA-4o2lA: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLM_A_198A1001_1 (ANDROGEN RECEPTOR)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	5 / 12	LEU A 83 LEU A 12 GLY A 13 GLN A 64 VAL A 98	None	1.35A	4olmA-4o2lA: undetectable	4olmA-4o2lA: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_D_CVID301_1 (REGULATORY PROTEIN TETR)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	4 / 8	GLN A 52 GLY A 51 ILE A 47 GLN A 154	None	1.06A	5vlmD-4o2lA: undetectable	5vlmD-4o2lA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YW0_A_ACTA411_0 (UNCHARACTERIZED PROTEIN KDOO)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	3 / 3	LYS A 161 LEU A 165 ARG A 162	None	0.88A	5yw0A-4o2lA: undetectable	5yw0A-4o2lA: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BEC_C_RBTC601_1 (SCAFFOLD PROTEIN D13)	4o2l	GTP-BINDING PROTEIN RHEB (Mus musculus)	5 / 12	VAL A 95 GLU A 40 VAL A 159 PHE A 160 ILE A 163	None	1.19A	6becA-4o2lA: undetectable 6becB-4o2lA: undetectable 6becC-4o2lA: undetectable	6becA-4o2lA: 15.08 6becB-4o2lA: 15.08 6becC-4o2lA: 15.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Q7L_A_TESA155_1","ANDROGEN RECEPTOR","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",5,"LEU A  83;LEU A  12;GLY A  13;GLN A  64;VAL A  98","None","1.40A","2q7lA-4o2lA:undetectable","2q7lA-4o2lA:18.77"],["3CB8_A_SAMA501_0","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",5,"SER A  68;LYS A  19;ARG A  15;VAL A  17;TYR A  85","None;GTP A 201 ( 2.6A);None;GTP A 201 (-4.1A);None","1.38A","3cb8A-4o2lA:1.9","3cb8A-4o2lA:21.72"],["4JTP_A_ASCA802_0","RRNA N-GLYCOSIDASE","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",4,"TYR A  81;ILE A  82;ASN A  79;ILE A 163","None","0.99A","4jtpA-4o2lA:undetectable","4jtpA-4o2lA:22.04"],["4OKT_A_198A1001_1","ANDROGEN RECEPTOR","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",5,"LEU A  83;LEU A  12;GLY A  13;GLN A  64;VAL A  98","None","1.40A","4oktA-4o2lA:undetectable","4oktA-4o2lA:19.31"],["4OLM_A_198A1001_1","ANDROGEN RECEPTOR","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",5,"LEU A  83;LEU A  12;GLY A  13;GLN A  64;VAL A  98","None","1.35A","4olmA-4o2lA:undetectable","4olmA-4o2lA:19.31"],["5VLM_D_CVID301_1","REGULATORY PROTEIN TETR","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",4,"GLN A  52;GLY A  51;ILE A  47;GLN A 154","None","1.06A","5vlmD-4o2lA:undetectable","5vlmD-4o2lA:22.27"],["5YW0_A_ACTA411_0","UNCHARACTERIZED PROTEIN KDOO","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",3,"LYS A 161;LEU A 165;ARG A 162","None","0.88A","5yw0A-4o2lA:undetectable","5yw0A-4o2lA:20.56"],["6BEC_C_RBTC601_1","SCAFFOLD PROTEIN D13;SCAFFOLD PROTEIN D13;SCAFFOLD PROTEIN D13","4o2l","GTP-BINDING PROTEIN RHEB","Mus musculus",5,"VAL A  95;GLU A  40;VAL A 159;PHE A 160;ILE A 163","None","1.19A","6becA-4o2lA:undetectable;6becB-4o2lA:undetectable;6becC-4o2lA:undetectable","6becA-4o2lA:15.08;6becB-4o2lA:15.08;6becC-4o2lA:15.08"]]