SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 6 VAL A4291
ILE A4293
TRP A4315
LEU A4323
 None
 1.07A 1j96A-4o2wA:
undetectable		 1j96A-4o2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 6 VAL A4149
THR A4150
LEU A4155
ARG A4179
 None
None
None
CL  A4404 (-4.0A)
 0.99A 1s8fB-4o2wA:
undetectable		 1s8fB-4o2wA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 9 ALA A4350
SER A4087
PHE A4143
GLY A4089
ALA A4300
 None
 1.34A 2vh3A-4o2wA:
undetectable		 2vh3A-4o2wA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 7 ILE A4269
LEU A4268
GLY A4247
THR A4262
 None
 0.81A 2wd9A-4o2wA:
undetectable		 2wd9A-4o2wA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 6 GLN A4009
GLY A4052
HIS A4354
CYH A4034
 None
 1.21A 3ai8B-4o2wA:
undetectable		 3ai8B-4o2wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 12 LEU A4306
ALA A4357
LEU A4340
ILE A4293
LEU A4304
 None
 1.31A 3olsB-4o2wA:
undetectable		 3olsB-4o2wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		3 / 3 TYR A4111
ASP A4108
ASP A4120
 None
 0.91A 3ou7B-4o2wA:
undetectable		 3ou7B-4o2wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 4 LEU A4219
GLY A4217
GLY A4214
THR A4225
 None
 0.95A 3si7A-4o2wA:
undetectable		 3si7A-4o2wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 4 GLY A4351
GLY A4035
THR A4039
LEU A4010
 None
 0.90A 3si7C-4o2wA:
undetectable
3si7D-4o2wA:
undetectable		 3si7C-4o2wA:
23.77
3si7D-4o2wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 12 LEU A4155
VAL A4180
PHE A4211
VAL A4191
PHE A4158
 None
 1.22A 3u9fH-4o2wA:
undetectable
3u9fI-4o2wA:
undetectable		 3u9fH-4o2wA:
17.04
3u9fI-4o2wA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 12 PHE A4158
LEU A4155
VAL A4180
PHE A4211
VAL A4191
 None
 1.22A 3u9fP-4o2wA:
undetectable
3u9fS-4o2wA:
undetectable		 3u9fP-4o2wA:
17.04
3u9fS-4o2wA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		3 / 3 TYR A4111
ASP A4108
ASP A4120
 None
 0.87A 4a6eA-4o2wA:
undetectable		 4a6eA-4o2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 10 PHE A4263
ASN A4278
HIS A4279
GLY A4264
SER A4251
 None
 1.11A 4a99A-4o2wA:
undetectable		 4a99A-4o2wA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 12 THR A4157
GLY A4159
ASN A4173
SER A4140
THR A4198
 None
 1.06A 4pooA-4o2wA:
undetectable		 4pooA-4o2wA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 4 THR A4335
LEU A4323
HIS A4327
GLY A4324
 None
 1.38A 5gwyA-4o2wA:
undetectable		 5gwyA-4o2wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		5 / 12 VAL A4296
ALA A4192
ALA A4245
VAL A4252
GLY A4142
 None
 1.09A 5igjA-4o2wA:
undetectable		 5igjA-4o2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens) 		4 / 8 GLY A4107
LEU A4059
GLY A4060
GLU A4053
 None
UNX  A4409 ( 3.9A)
UNX  A4409 ( 4.5A)
None
 0.51A 6mdqA-4o2wA:
undetectable		 6mdqA-4o2wA:
13.79