SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		4 / 7 LEU A 364
ILE A  95
ARG A  99
TRP A 352
 None
 1.02A 2hc4A-4o2zA:
undetectable		 2hc4A-4o2zA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		4 / 6 LEU A  53
LYS A  76
MET A  98
MET A 133
 046  A 401 ( 3.9A)
046  A 401 ( 4.7A)
046  A 401 (-3.5A)
None
 0.91A 2hyyC-4o2zA:
22.1		 2hyyC-4o2zA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		4 / 6 ASP A 175
ARG A 217
VAL A 232
ARG A 174
 046  A 401 (-4.4A)
None
None
None
 1.20A 2yfbB-4o2zA:
2.2		 2yfbB-4o2zA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 GLU A  94
MET A  98
LEU A 106
THR A 130
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.0A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.69A 3cs9B-4o2zA:
21.3		 3cs9B-4o2zA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 GLU A  94
MET A  98
LEU A 106
THR A 130
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.0A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.67A 3cs9C-4o2zA:
21.1		 3cs9C-4o2zA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 12 GLU A  94
MET A  98
LEU A 106
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.59A 3ik3A-4o2zA:
21.6		 3ik3A-4o2zA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 12 GLU A  94
MET A  98
LEU A 106
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.63A 3ik3B-4o2zA:
21.6		 3ik3B-4o2zA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 12 THR A 213
ILE A 159
ASP A 175
ARG A 174
LEU A 176
 None
None
046  A 401 (-4.4A)
None
None
 1.23A 3iv6D-4o2zA:
undetectable		 3iv6D-4o2zA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		4 / 8 THR A 183
LEU A 189
GLN A 158
HIS A 151
 None
 0.87A 3kp2A-4o2zA:
undetectable
3kp2B-4o2zA:
undetectable		 3kp2A-4o2zA:
18.79
3kp2B-4o2zA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 GLU A  94
MET A  98
LEU A 106
THR A 130
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.0A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.66A 3oxzA-4o2zA:
20.9		 3oxzA-4o2zA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		3 / 3 ARG A 161
GLU A 104
ASN A 105
 None
 0.68A 4imaD-4o2zA:
undetectable		 4imaD-4o2zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		3 / 3 ARG A 161
GLU A 104
ASN A 105
 None
 0.66A 4ip7D-4o2zA:
undetectable		 4ip7D-4o2zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 GLU A  94
MET A  97
MET A  98
LEU A 166
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
None
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.77A 4v01A-4o2zA:
21.3		 4v01A-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 ALA A  61
GLU A  94
MET A  97
MET A  98
HIS A 173
ASP A 193
 046  A 401 ( 4.6A)
046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 1.06A 4v01B-4o2zA:
21.8		 4v01B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		6 / 12 GLU A  94
MET A  97
MET A  98
LEU A 166
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
None
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.69A 4v01B-4o2zA:
21.8		 4v01B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 12 ALA A  61
GLU A  94
MET A  97
HIS A 173
ASP A 193
 046  A 401 ( 4.6A)
046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.91A 4v04B-4o2zA:
21.8		 4v04B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 11 TYR A 120
VAL A 373
ILE A 372
LEU A 364
PHE A 123
 None
 1.34A 5huaA-4o2zA:
undetectable		 5huaA-4o2zA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE
(Leishmania
donovani) 		5 / 9 ASN A 105
ILE A 234
PHE A 310
SER A 236
GLY A 238
 None
 1.47A 6awpA-4o2zA:
undetectable		 6awpA-4o2zA:
19.58