SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
VAL A  99
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.5A)
None
 0.72A 1fmoE-4o38A:
21.2		 1fmoE-4o38A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 THR A 329
LEU A 331
GLY A 185
LYS A 150
 None
 1.22A 1gtiC-4o38A:
undetectable		 1gtiC-4o38A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 5 THR A 329
LEU A 331
GLY A 185
LYS A 150
 None
 1.16A 1gtiF-4o38A:
undetectable		 1gtiF-4o38A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.84A 1iepA-4o38A:
19.2		 1iepA-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
 0.76A 1iepB-4o38A:
19.1		 1iepB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.63A 1m17A-4o38A:
20.8		 1m17A-4o38A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.76A 1opjA-4o38A:
19.4		 1opjA-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
None
 0.96A 1opjB-4o38A:
19.0		 1opjB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
 0.79A 1opjB-4o38A:
19.0		 1opjB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.72A 1t46A-4o38A:
20.9		 1t46A-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 12 ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.66A 1uwhA-4o38A:
21.0		 1uwhA-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
None
 0.68A 1uwhB-4o38A:
21.0		 1uwhB-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.54A 1uwjA-4o38A:
20.6		 1uwjA-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.54A 1uwjB-4o38A:
20.9		 1uwjB-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 9 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.46A 1xbbA-4o38A:
22.0		 1xbbA-4o38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 9 LEU A  46
VAL A  54
LYS A  69
LEU A 121
LEU A 125
 SIN  A 401 ( 3.9A)
None
None
None
SIN  A 401 ( 4.8A)
 0.59A 1xkkA-4o38A:
18.7		 1xkkA-4o38A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
ALA A  67
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.66A 2gqgA-4o38A:
21.4		 2gqgA-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.58A 2gqgB-4o38A:
22.2		 2gqgB-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.77A 2gqgB-4o38A:
22.2		 2gqgB-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 7 LEU A 256
LEU A 253
ILE A 246
ARG A 303
 None
 1.20A 2hc4A-4o38A:
undetectable		 2hc4A-4o38A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.85A 2hyyA-4o38A:
19.3		 2hyyA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.83A 2hyyB-4o38A:
19.3		 2hyyB-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.95A 2hyyC-4o38A:
19.7		 2hyyC-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.63A 2hyyC-4o38A:
19.7		 2hyyC-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.88A 2hyyD-4o38A:
19.3		 2hyyD-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.68A 2itoA-4o38A:
21.0		 2itoA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
 0.77A 2itoA-4o38A:
21.0		 2itoA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.87A 2ityA-4o38A:
20.7		 2ityA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
None
 0.85A 2ityA-4o38A:
20.7		 2ityA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.74A 2itzA-4o38A:
20.9		 2itzA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
 0.77A 2itzA-4o38A:
20.9		 2itzA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.73A 2itzA-4o38A:
20.9		 2itzA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		3 / 3 LEU A 149
TYR A 153
GLN A 154
 None
 0.64A 2wekA-4o38A:
undetectable		 2wekA-4o38A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 9 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.70A 2xp2A-4o38A:
20.8		 2xp2A-4o38A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.75A 2y6oA-4o38A:
21.3		 2y6oA-4o38A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.94A 2zvaA-4o38A:
21.8		 2zvaA-4o38A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.74A 2zvaA-4o38A:
21.8		 2zvaA-4o38A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 10 ARG A  44
LEU A  46
ALA A  67
LYS A  69
VAL A  99
LEU A 125
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.73A 3aoxA-4o38A:
20.2		 3aoxA-4o38A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
THR A 123
LEU A 125
GLY A 128
LEU A 180
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.77A 3bbtB-4o38A:
18.5		 3bbtB-4o38A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LEU A 121
THR A 123
GLY A 128
LEU A 180
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.77A 3bbtD-4o38A:
18.8		 3bbtD-4o38A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
LEU A 121
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.84A 3bbtD-4o38A:
18.8		 3bbtD-4o38A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
GLU A  56
ALA A  67
LYS A  69
VAL A  99
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.72A 3c7qA-4o38A:
19.9		 3c7qA-4o38A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
HIS A 171
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.83A 3cs9A-4o38A:
19.5		 3cs9A-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
 0.82A 3cs9B-4o38A:
20.0		 3cs9B-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 12 ALA A  67
GLU A  85
MET A  89
THR A 123
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
None
 0.86A 3cs9C-4o38A:
19.5		 3cs9C-4o38A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 11 LEU A  46
VAL A  54
ALA A  67
VAL A  99
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.67A 3g0eA-4o38A:
19.2		 3g0eA-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 11 VAL A  54
ALA A  67
VAL A  99
THR A 123
CYH A 126
LEU A 180
CYH A 190
ALA A  47
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
None
 1.16A 3g0eA-4o38A:
19.2		 3g0eA-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 11 LEU A  46
VAL A  54
ALA A  67
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.70A 3g0fA-4o38A:
20.1		 3g0fA-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 10 LEU A  46
VAL A  54
ALA A  67
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.61A 3g0fB-4o38A:
20.2		 3g0fB-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.63A 3g5dA-4o38A:
21.3		 3g5dA-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.82A 3g5dA-4o38A:
21.3		 3g5dA-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.70A 3g5dB-4o38A:
21.3		 3g5dB-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.82A 3g5dB-4o38A:
21.3		 3g5dB-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 1.01A 3gvuA-4o38A:
20.1		 3gvuA-4o38A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.77A 3gvuA-4o38A:
20.1		 3gvuA-4o38A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 12 ALA A  67
LYS A  69
GLU A  85
THR A 123
LEU A 125
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
 0.34A 3hecA-4o38A:
18.1		 3hecA-4o38A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.86A 3k54A-4o38A:
20.5		 3k54A-4o38A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.69A 3k54A-4o38A:
20.5		 3k54A-4o38A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.82A 3k5vA-4o38A:
19.2		 3k5vA-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.80A 3k5vB-4o38A:
19.1		 3k5vB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 8 ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
LEU A 125
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.8A)
 0.37A 3lfaA-4o38A:
17.8		 3lfaA-4o38A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.80A 3ms9A-4o38A:
19.0		 3ms9A-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.82A 3ms9B-4o38A:
19.0		 3ms9B-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.83A 3mssA-4o38A:
19.1		 3mssA-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
 0.79A 3mssB-4o38A:
19.1		 3mssB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.76A 3mssB-4o38A:
19.1		 3mssB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.84A 3mssC-4o38A:
19.1		 3mssC-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
 0.95A 3mssD-4o38A:
19.1		 3mssD-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.84A 3mssD-4o38A:
19.1		 3mssD-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.71A 3octA-4o38A:
20.6		 3octA-4o38A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.79A 3oezA-4o38A:
19.7		 3oezA-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.73A 3oezA-4o38A:
19.7		 3oezA-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.67A 3og7A-4o38A:
20.9		 3og7A-4o38A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
None
 0.81A 3oxzA-4o38A:
19.4		 3oxzA-4o38A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
HIS A 171
ASP A 191
 None
None
None
None
SIN  A 401 (-3.5A)
None
None
 1.10A 3oxzA-4o38A:
19.4		 3oxzA-4o38A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 1.05A 3pyyB-4o38A:
18.8		 3pyyB-4o38A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.74A 3pyyB-4o38A:
18.8		 3pyyB-4o38A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.89A 3qlgA-4o38A:
20.9		 3qlgA-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.83A 3qlgB-4o38A:
21.4		 3qlgB-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 5 GLY A 241
ASP A 245
ARG A 172
GLN A 165
 None
 1.34A 3qx3B-4o38A:
undetectable		 3qx3B-4o38A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 8 ILE A 316
LEU A 313
PHE A 152
GLY A 250
 None
 0.96A 3selX-4o38A:
undetectable		 3selX-4o38A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
ALA A  67
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.77A 3sxrA-4o38A:
20.5		 3sxrA-4o38A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.47A 3sxrA-4o38A:
20.5		 3sxrA-4o38A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.74A 3sxrB-4o38A:
20.1		 3sxrB-4o38A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.69A 3ue4A-4o38A:
21.7		 3ue4A-4o38A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.70A 3ue4B-4o38A:
21.7		 3ue4B-4o38A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
LEU A 121
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.88A 3ug2A-4o38A:
20.2		 3ug2A-4o38A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 LEU A  46
ALA A  67
CYH A 126
GLY A 128
CYH A 190
PHE A 192
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
None
 0.92A 3wzdA-4o38A:
20.2		 3wzdA-4o38A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
CYH A 126
GLY A 128
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
 0.79A 3wzdA-4o38A:
20.2		 3wzdA-4o38A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 8 VAL A  99
CYH A 126
LEU A 180
CYH A 190
ASP A 191
 None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
None
 0.94A 3wzeA-4o38A:
20.4		 3wzeA-4o38A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
THR A 123
HIS A 171
ARG A 172
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.75A 3zosA-4o38A:
19.9		 3zosA-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
LYS A  69
GLU A  85
THR A 123
HIS A 171
ARG A 172
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.77A 3zosB-4o38A:
20.0		 3zosB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
VAL A  99
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.66A 4ag8A-4o38A:
20.4		 4ag8A-4o38A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.68A 4agcA-4o38A:
20.0		 4agcA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 11 LEU A  46
ALA A  67
LYS A  69
VAL A  99
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.82A 4agdA-4o38A:
19.8		 4agdA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 9 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.77A 4anqA-4o38A:
20.5		 4anqA-4o38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 VAL A  99
CYH A 126
LEU A 180
CYH A 190
 None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
 0.52A 4asdA-4o38A:
20.1		 4asdA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
None
 0.93A 4bkjB-4o38A:
19.8		 4bkjB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.96A 4bkjB-4o38A:
19.8		 4bkjB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
LYS A  69
GLU A  85
ILE A  98
THR A 123
HIS A 171
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.68A 4c8bB-4o38A:
21.3		 4c8bB-4o38A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 1.09A 4csvA-4o38A:
20.4		 4csvA-4o38A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 7 ILE A 316
LEU A 313
PHE A 152
GLY A 250
 None
 0.85A 4hbfA-4o38A:
undetectable		 4hbfA-4o38A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 7 ILE A 316
LEU A 313
PHE A 152
GLY A 250
 None
 0.87A 4hc3A-4o38A:
undetectable		 4hc3A-4o38A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.65A 4hjoA-4o38A:
19.3		 4hjoA-4o38A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
LEU A 121
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.77A 4i22A-4o38A:
18.8		 4i22A-4o38A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 5 GLN A 184
THR A 147
LEU A 130
LEU A 181
 None
 1.12A 4lvcB-4o38A:
undetectable		 4lvcB-4o38A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 9 TYR A 276
GLY A 250
LEU A 255
PRO A 262
VAL A 176
 None
 1.46A 4mjrA-4o38A:
undetectable		 4mjrA-4o38A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.95A 4mxoA-4o38A:
21.3		 4mxoA-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.89A 4mxxA-4o38A:
21.3		 4mxxA-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.73A 4mxxB-4o38A:
20.1		 4mxxB-4o38A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
VAL A  99
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.95A 4mxyA-4o38A:
21.4		 4mxyA-4o38A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
VAL A  99
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.95A 4mxzA-4o38A:
21.4		 4mxzA-4o38A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 VAL A  54
ALA A  67
LYS A  69
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.5A)
 0.66A 4o0uA-4o38A:
21.6		 4o0uA-4o38A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 7 ALA A  67
CYH A 126
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
None
SIN  A 401 ( 4.5A)
None
 0.71A 4ogrE-4o38A:
21.7		 4ogrE-4o38A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 9 VAL A  54
ALA A  67
CYH A 126
ASN A 178
LEU A 180
ASP A 191
 None
SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
None
SIN  A 401 ( 4.5A)
None
 0.70A 4ogrI-4o38A:
15.1		 4ogrI-4o38A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.85A 4otwA-4o38A:
18.4		 4otwA-4o38A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 LYS A  69
LEU A  71
THR A 123
SER A 106
 None
 0.78A 4pwjA-4o38A:
undetectable		 4pwjA-4o38A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 7 LYS A  69
LEU A  71
THR A 123
SER A 106
 None
 0.78A 4pwjB-4o38A:
undetectable		 4pwjB-4o38A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 0.84A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
 0.66A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.67A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
 0.39A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 10 ALA A  67
LYS A  69
THR A 123
LEU A 125
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 ( 4.5A)
 0.55A 4rz7A-4o38A:
22.0		 4rz7A-4o38A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.73A 4rzvB-4o38A:
20.1		 4rzvB-4o38A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLY A 128
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.60A 4twpA-4o38A:
21.0		 4twpA-4o38A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLY A 128
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.63A 4twpB-4o38A:
21.5		 4twpB-4o38A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 10 LEU A  46
VAL A  54
GLU A  85
LEU A  92
ILE A  98
VAL A  99
 SIN  A 401 ( 3.9A)
None
None
None
None
None
 0.68A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 ALA A  67
LYS A  69
THR A 123
CYH A 126
GLY A 128
HIS A 171
LEU A 180
CYH A 190
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.59A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LYS A  69
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
ASP A 191
 None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
None
 0.77A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 11 LEU A  46
ALA A  67
LYS A  69
THR A 123
GLY A 128
ASN A 178
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 1.36A 4wa9A-4o38A:
17.5		 4wa9A-4o38A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
GLY A 128
ASN A 178
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.71A 4wa9B-4o38A:
20.7		 4wa9B-4o38A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 ARG A  44
LEU A  46
ALA A  67
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 ( 4.5A)
 0.68A 4wboC-4o38A:
20.5		 4wboC-4o38A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.65A 4wkqA-4o38A:
20.7		 4wkqA-4o38A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.74A 4xeyA-4o38A:
21.2		 4xeyA-4o38A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.62A 4xeyB-4o38A:
20.6		 4xeyB-4o38A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.77A 4xliA-4o38A:
22.3		 4xliA-4o38A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.81A 4xliB-4o38A:
21.9		 4xliB-4o38A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
ASP A 191
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
None
 0.74A 4xv2A-4o38A:
20.9		 4xv2A-4o38A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
LYS A  69
THR A 123
CYH A 126
ASP A 191
PHE A 192
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
None
 0.71A 4xv2B-4o38A:
21.0		 4xv2B-4o38A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 9 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.68A 5aaaA-4o38A:
20.8		 5aaaA-4o38A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 10 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.75A 5aabA-4o38A:
20.6		 5aabA-4o38A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
ALA A  67
LYS A  69
CYH A 126
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 1.05A 5ajqA-4o38A:
21.0		 5ajqA-4o38A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 7 LYS A  69
LEU A  71
THR A 123
SER A 106
 None
 0.69A 5bojB-4o38A:
undetectable		 5bojB-4o38A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.77A 5bvwA-4o38A:
12.7		 5bvwA-4o38A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.57A 5cswA-4o38A:
20.7		 5cswA-4o38A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.62A 5cswB-4o38A:
20.9		 5cswB-4o38A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 5 LEU A 253
PHE A 258
ARG A 293
ILE A 278
 None
 1.06A 5dzk4-4o38A:
undetectable
5dzkg-4o38A:
undetectable
5dzkm-4o38A:
undetectable
5dzkn-4o38A:
undetectable		 5dzk4-4o38A:
3.17
5dzkg-4o38A:
19.76
5dzkm-4o38A:
21.79
5dzkn-4o38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
THR A 123
LEU A 125
GLY A 128
GLU A 132
LEU A 180
 SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 1.29A 5h2uA-4o38A:
18.7		 5h2uA-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ARG A  44
LEU A  46
VAL A  54
ALA A  67
THR A 123
LEU A 125
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
 0.79A 5h2uA-4o38A:
18.7		 5h2uA-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.59A 5h2uA-4o38A:
18.7		 5h2uA-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ARG A  44
LEU A  46
ALA A  67
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 1.02A 5h2uC-4o38A:
18.8		 5h2uC-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ARG A  44
LEU A  46
ALA A  67
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.66A 5h2uC-4o38A:
18.8		 5h2uC-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
VAL A  54
ALA A  67
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.59A 5h2uD-4o38A:
18.9		 5h2uD-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 190
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
None
None
 0.76A 5hesB-4o38A:
19.0		 5hesB-4o38A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
None
 0.67A 5hi2A-4o38A:
21.2		 5hi2A-4o38A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 12 VAL A  54
ALA A  67
LYS A  69
THR A 123
ASP A 191
 None
SIN  A 401 ( 3.7A)
None
None
None
 0.55A 5hieC-4o38A:
20.0		 5hieC-4o38A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 8 ALA A  67
GLU A  85
CYH A 126
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
 0.59A 5owrA-4o38A:
21.8		 5owrA-4o38A:
26.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 ALA A  47
ALA A  67
GLU A  85
VAL A  99
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.85A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 ALA A  67
GLU A  85
MET A  89
VAL A  99
GLY A 128
GLN A 129
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.79A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 5 LEU A  46
VAL A  54
CYH A 126
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 (-4.3A)
None
 0.52A 5te0A-4o38A:
26.9		 5te0A-4o38A:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
LEU A 121
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
 1.08A 5vcvA-4o38A:
21.8		 5vcvA-4o38A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
CYH A 126
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-4.3A)
 0.78A 5vcyA-4o38A:
21.6		 5vcyA-4o38A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		5 / 9 LEU A  46
ALA A  67
VAL A  99
CYH A 126
GLY A 128
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
 0.45A 5w5vA-4o38A:
11.9		 5w5vA-4o38A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 ARG A  44
LEU A  46
VAL A  54
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.52A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 ARG A  44
LEU A  46
VAL A  54
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.52A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
97.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		11 / 12 ARG A  44
LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.75A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		11 / 12 ARG A  44
LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.75A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
97.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
ALA A  67
GLU A  85
LEU A 121
LEU A 125
CYH A 126
GLY A 128
LEU A 180
CYH A 190
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
None
 0.73A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.61A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 121
LEU A 125
GLY A 128
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
None
 0.86A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 125
GLY A 128
GLU A 132
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
None
 0.73A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		9 / 12 ALA A  67
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.67A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.47A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		10 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
 0.57A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		6 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
 0.55A 5zv2B-4o38A:
20.3		 5zv2B-4o38A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		4 / 6 GLN A 154
VAL A 322
LEU A 179
MET A 295
 None
 1.29A 6brdB-4o38A:
undetectable		 6brdB-4o38A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.79A 6bsdA-4o38A:
19.4		 6bsdA-4o38A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.85A 6hd4A-4o38A:
19.1		 6hd4A-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.78A 6hd4A-4o38A:
19.1		 6hd4A-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.81A 6hd4B-4o38A:
19.0		 6hd4B-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.80A 6hd4B-4o38A:
19.0		 6hd4B-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.85A 6hd6A-4o38A:
19.2		 6hd6A-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		7 / 12 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.79A 6hd6A-4o38A:
19.2		 6hd6A-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 1.01A 6hd6B-4o38A:
18.9		 6hd6B-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.83A 6hd6B-4o38A:
18.9		 6hd6B-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens) 		8 / 12 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.77A 6hd6B-4o38A:
18.9		 6hd6B-4o38A:
14.42