SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 958
ILE A 892
ILE A 943
PHE A 949
ASP A 957
 None
 1.06A 1qhyA-4o3mA:
5.4		 1qhyA-4o3mA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 TYR A1274
GLY A 664
ILE A1240
VAL A1225
LEU A1249
 None
EDO  A1305 (-3.4A)
None
None
None
 1.20A 1r30A-4o3mA:
undetectable		 1r30A-4o3mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 TYR A1274
GLY A 664
ILE A1240
VAL A1225
LEU A1249
 None
EDO  A1305 (-3.4A)
None
None
None
 1.20A 1r30B-4o3mA:
undetectable		 1r30B-4o3mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 979
ARG A 982
ILE A 935
 None
 0.57A 1uobA-4o3mA:
undetectable		 1uobA-4o3mA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 882
ARG A 883
LEU A 908
ASP A 911
 None
 0.97A 2rlfA-4o3mA:
undetectable
2rlfD-4o3mA:
undetectable		 2rlfA-4o3mA:
6.37
2rlfD-4o3mA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 PHE A1238
LYS A 726
SER A 729
 None
 0.74A 3tyeB-4o3mA:
undetectable		 3tyeB-4o3mA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 7 THR A 779
LEU A 783
VAL A 709
VAL A 765
 None
 1.04A 3wrhA-4o3mA:
undetectable		 3wrhA-4o3mA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 7 THR A 779
LEU A 783
VAL A 709
VAL A 765
 None
 1.04A 3wrlA-4o3mA:
undetectable		 3wrlA-4o3mA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 960
GLN A 941
VAL A 942
ILE A 943
ILE A 953
 None
 1.05A 4drhD-4o3mA:
undetectable		 4drhD-4o3mA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A1001
THR A 999
VAL A1027
LEU A 966
TYR A 993
 None
 1.13A 4g1bA-4o3mA:
undetectable		 4g1bA-4o3mA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 780
LEU A 783
LEU A 763
ILE A 770
ILE A 713
 None
 0.94A 4j24A-4o3mA:
undetectable		 4j24A-4o3mA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 859
GLU A 796
TYR A 974
 EDO  A1304 (-3.6A)
None
None
 0.94A 4r29D-4o3mA:
undetectable		 4r29D-4o3mA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 THR A 999
HIS A1091
LEU A1114
 None
 0.61A 5axdA-4o3mA:
undetectable		 5axdA-4o3mA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 GLU A 900
HIS A 963
LEU A 991
ARG A1000
LEU A1001
 None
 1.22A 5nd7B-4o3mA:
undetectable		 5nd7B-4o3mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 7 THR A 779
LEU A 783
VAL A 709
VAL A 765
 None
 1.04A 5wk9A-4o3mA:
undetectable		 5wk9A-4o3mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 4 HIS A 919
VAL A 930
LEU A 922
ALA A 917
 None
 0.97A 6d8pB-4o3mA:
3.0		 6d8pB-4o3mA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 859
HIS A 860
ARG A1038
 EDO  A1304 (-3.6A)
None
None
 1.08A 6dwdD-4o3mA:
undetectable		 6dwdD-4o3mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		4 / 6 GLN A 838
LEU A 688
SER A 854
PHE A 686
 None
 1.15A 6ekuA-4o3mA:
undetectable		 6ekuA-4o3mA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 693
GLY A 692
GLN A 700
PRO A 956
GLY A 981
 ADP  A1303 (-3.8A)
ADP  A1303 ( 3.6A)
None
None
None
 0.98A 6gneA-4o3mA:
undetectable		 6gneA-4o3mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 693
GLY A 692
GLN A 700
PRO A 956
GLY A 981
 ADP  A1303 (-3.8A)
ADP  A1303 ( 3.6A)
None
None
None
 0.98A 6gneB-4o3mA:
undetectable		 6gneB-4o3mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens) 		3 / 3 TRP A 934
ILE A 953
GLU A 976
 None
 0.75A 6hcxA-4o3mA:
undetectable		 6hcxA-4o3mA:
8.05