SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 12 SER A 265
VAL A 266
GLY A 263
LEU A 258
VAL A 221
 None
 1.10A 1fduC-4o3sA:
undetectable		 1fduC-4o3sA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 7 ARG A 256
ILE A 255
LEU A 278
GLY A 276
PHE A 247
 None
None
None
GOL  A 504 (-3.2A)
None
 1.21A 1rtsB-4o3sA:
undetectable		 1rtsB-4o3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 6 ALA A 112
GLU A 110
ILE A 109
LEU A  11
 None
 0.97A 1xvaA-4o3sA:
undetectable
1xvaB-4o3sA:
undetectable		 1xvaA-4o3sA:
20.18
1xvaB-4o3sA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 7 ILE A 255
LEU A 278
GLY A 276
PHE A 247
 None
None
GOL  A 504 (-3.2A)
None
 0.90A 2tsrA-4o3sA:
undetectable		 2tsrA-4o3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 VAL A 243
LEU A 225
VAL A 221
ILE A 255
ALA A 300
 None
 0.96A 2zbzA-4o3sA:
undetectable		 2zbzA-4o3sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 VAL A 243
LEU A 225
VAL A 221
MET A 250
ALA A 300
 None
 1.25A 2zbzA-4o3sA:
undetectable		 2zbzA-4o3sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		3 / 3 GLU A 306
SER A 217
VAL A 238
 None
 0.82A 3eeoA-4o3sA:
undetectable		 3eeoA-4o3sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 6 GLU A 101
ASP A 358
ASP A 355
LYS A 354
 None
 1.49A 3pocB-4o3sA:
undetectable		 3pocB-4o3sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 6 VAL A 119
VAL A 125
ILE A 216
ARG A 105
 None
 1.06A 3pyyA-4o3sA:
undetectable		 3pyyA-4o3sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 4 ASP A  66
ASP A  67
GLY A  46
THR A  60
 None
 1.06A 3tl9B-4o3sA:
undetectable		 3tl9B-4o3sA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 12 LEU A 171
LEU A 142
LEU A 141
VAL A 197
ARG A 128
 None
 1.19A 3zqtA-4o3sA:
undetectable		 3zqtA-4o3sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 7 ILE A 255
LEU A 278
GLY A 276
PHE A 247
 None
None
GOL  A 504 (-3.2A)
None
 0.87A 4iqqB-4o3sA:
undetectable		 4iqqB-4o3sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 10 ALA A  54
ALA A  65
CYH A  72
ALA A  68
ILE A  47
 None
 1.01A 4lbgA-4o3sA:
undetectable		 4lbgA-4o3sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 9 ALA A  54
ALA A  65
CYH A  72
ALA A  68
ILE A  47
 None
 0.99A 4lbgB-4o3sA:
undetectable		 4lbgB-4o3sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 7 PHE A  17
ASP A  15
GLN A  20
ILE A 204
 None
0KX  A 501 (-4.8A)
None
None
 0.98A 4pcuA-4o3sA:
undetectable		 4pcuA-4o3sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		3 / 3 VAL A  21
TYR A  92
ALA A  95
 None
 0.48A 4ybnA-4o3sA:
undetectable		 4ybnA-4o3sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 12 MET A 200
ILE A 196
ALA A 112
ALA A 117
VAL A  12
 None
 0.94A 5igjA-4o3sA:
undetectable		 5igjA-4o3sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 12 MET A 200
ILE A 196
ALA A 112
ALA A 117
VAL A  12
 None
 0.91A 5igpA-4o3sA:
undetectable		 5igpA-4o3sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 10 SER A 257
GLU A 306
GLU A 110
TYR A 118
GLU A 116
 None
None
None
None
MG  A 503 (-3.0A)
 1.46A 5iqcB-4o3sA:
1.2		 5iqcB-4o3sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 10 SER A 257
GLU A 306
GLU A 110
TYR A 118
GLU A 116
 None
None
None
None
MG  A 503 (-3.0A)
 1.40A 5iqgA-4o3sA:
undetectable		 5iqgA-4o3sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 10 SER A 257
GLU A 306
GLU A 110
TYR A 118
GLU A 116
 None
None
None
None
MG  A 503 (-3.0A)
 1.48A 5iqgB-4o3sA:
1.0		 5iqgB-4o3sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 10 SER A 257
GLU A 306
GLU A 110
TYR A 118
GLU A 116
 None
None
None
None
MG  A 503 (-3.0A)
 1.46A 5iqgD-4o3sA:
0.0		 5iqgD-4o3sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 ALA A  35
ALA A  78
GLY A  46
GLY A  45
ALA A  65
 None
 1.00A 5lf3K-4o3sA:
undetectable
5lf3L-4o3sA:
undetectable		 5lf3K-4o3sA:
16.47
5lf3L-4o3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 ALA A  35
ALA A  78
GLY A  46
GLY A  45
ALA A  65
 None
 1.01A 5lf3Y-4o3sA:
undetectable
5lf3Z-4o3sA:
undetectable		 5lf3Y-4o3sA:
16.47
5lf3Z-4o3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 12 VAL A 197
GLU A 199
LEU A 237
ALA A 194
ARG A 128
 None
 1.30A 5nd4B-4o3sA:
undetectable		 5nd4B-4o3sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 VAL A  37
SER A  41
ASP A  66
ALA A  65
LEU A  77
 None
 1.09A 5x6yA-4o3sA:
undetectable		 5x6yA-4o3sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		5 / 11 VAL A  37
SER A  41
ASP A  66
ALA A  65
LEU A  77
 None
 1.11A 5x6yC-4o3sA:
undetectable		 5x6yC-4o3sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4o3s DNA POLYMERASE ETA
(Homo
sapiens) 		4 / 6 ASP A 115
ASP A  13
GLN A  20
LYS A 231
 MG  A 503 (-2.6A)
MG  A 502 (-2.5A)
None
0KX  A 501 (-3.1A)
 1.42A 6g31L-4o3sA:
undetectable		 6g31L-4o3sA:
11.61