SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		5 / 12 TYR B 162
GLY B 177
LEU B 178
PHE B 245
PRO B 160
 None
 1.25A 1vpoH-4o3xB:
undetectable
1vpoL-4o3xB:
undetectable		 1vpoH-4o3xB:
23.69
1vpoL-4o3xB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		4 / 5 PHE B 194
LEU B 207
PHE B 226
SER B 252
 None
 1.12A 1wrkB-4o3xB:
undetectable		 1wrkB-4o3xB:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		5 / 9 ALA B 230
ALA B 232
SER B 247
SER B 250
ALA B 271
 None
 1.39A 2vh3A-4o3xB:
undetectable		 2vh3A-4o3xB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		5 / 12 ASN B 244
SER B 247
VAL B  51
ILE B  65
ASN B 150
 None
 1.33A 3jb3A-4o3xB:
undetectable		 3jb3A-4o3xB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		5 / 10 SER B 149
PHE B 245
SER B 180
GLU B 112
ASP B  92
 None
 1.36A 4qb9A-4o3xB:
undetectable		 4qb9A-4o3xB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		4 / 6 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.11A 5igyA-4o3xB:
undetectable		 5igyA-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		4 / 6 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.13A 5ih0A-4o3xB:
undetectable		 5ih0A-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER B 105
TYR B 124
TYR B 123
 None
 0.71A 5lakA-4o3xB:
undetectable
5lakI-4o3xB:
undetectable		 5lakA-4o3xB:
22.77
5lakI-4o3xB:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4o3x TRANSFERRIN BINDING
PROTEIN B
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER B 105
TYR B 124
TYR B 123
 None
 0.71A 5lakC-4o3xB:
undetectable
5lakJ-4o3xB:
undetectable		 5lakC-4o3xB:
22.77
5lakJ-4o3xB:
3.88