SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 6 LEU A 238
GLU A 247
ALA A 249
LEU A 235
 None
 1.13A 1etb1-4o48A:
undetectable		 1etb1-4o48A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 ALA A 173
VAL A   6
TRP A 275
 None
 1.01A 1gmkA-4o48A:
undetectable
1gmkB-4o48A:
undetectable		 1gmkA-4o48A:
3.68
1gmkB-4o48A:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 GLY A   9
ALA A  12
GLY A 188
THR A 219
ILE A 189
 None
None
ASP  A 402 (-3.6A)
ASP  A 402 (-3.7A)
ASP  A 402 (-4.5A)
 1.02A 1gtnL-4o48A:
undetectable
1gtnV-4o48A:
undetectable		 1gtnL-4o48A:
14.56
1gtnV-4o48A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 4 HIS A  65
ALA A  59
PHE A  61
GLY A  64
 None
None
None
NA  A 401 ( 4.4A)
 1.37A 1mjoA-4o48A:
undetectable		 1mjoA-4o48A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.01A 1q23A-4o48A:
undetectable		 1q23A-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.08A 1q23F-4o48A:
undetectable		 1q23F-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.01A 1q23K-4o48A:
undetectable		 1q23K-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 GLY A 188
THR A 219
ILE A 189
GLY A   9
ALA A  12
 ASP  A 402 (-3.6A)
ASP  A 402 (-3.7A)
ASP  A 402 (-4.5A)
None
None
 1.04A 1utdO-4o48A:
0.4
1utdP-4o48A:
0.4		 1utdO-4o48A:
14.56
1utdP-4o48A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ASP A 199
GLY A  10
ALA A 231
ILE A 225
 ASP  A 402 (-3.0A)
None
None
None
 0.96A 2aofA-4o48A:
undetectable		 2aofA-4o48A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 10 GLU A  49
ILE A 102
ARG A 106
ASP A  83
ASP A 110
 None
 1.40A 2qeoB-4o48A:
undetectable		 2qeoB-4o48A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 LEU A 233
THR A 218
GLY A 265
GLY A 264
THR A 280
 None
 1.08A 2uvnA-4o48A:
undetectable		 2uvnA-4o48A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 GLY A 198
ASP A  78
SER A  93
 ASP  A 402 ( 3.9A)
None
None
 0.39A 3brfA-4o48A:
undetectable		 3brfA-4o48A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 GLY A  11
GLY A 188
ASN A  62
PHE A  61
ILE A 189
 None
ASP  A 402 (-3.6A)
None
None
ASP  A 402 (-4.5A)
 1.29A 3k13C-4o48A:
undetectable		 3k13C-4o48A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 11 THR A 219
THR A 184
ALA A  79
GLY A   9
SER A 217
 ASP  A 402 (-3.7A)
None
None
None
None
 1.20A 3mg0N-4o48A:
2.1		 3mg0N-4o48A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 VAL A 108
VAL A  95
SER A  93
 None
 0.72A 3n8xB-4o48A:
undetectable		 3n8xB-4o48A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 ALA A  31
ALA A  30
LEU A  55
ALA A 287
ILE A  81
 None
 1.15A 3uvvB-4o48A:
undetectable		 3uvvB-4o48A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 MET A 284
VAL A 216
VAL A 245
ALA A 249
LEU A 253
 None
 0.88A 4m11D-4o48A:
0.9		 4m11D-4o48A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 ALA A  91
LEU A 104
GLY A 119
PHE A 125
ALA A  94
 None
 1.05A 4pclA-4o48A:
undetectable		 4pclA-4o48A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 ALA A 287
GLY A  26
ILE A 102
ALA A 183
GLY A 170
 None
 1.11A 4r29D-4o48A:
0.4		 4r29D-4o48A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 ARG A 196
THR A 186
ASP A  78
 ASP  A 402 (-2.7A)
ASP  A 402 (-3.7A)
None
 0.84A 5g5gA-4o48A:
undetectable
5g5gB-4o48A:
undetectable		 5g5gA-4o48A:
22.22
5g5gB-4o48A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 ILE A 213
GLY A 214
ALA A 252
ILE A 203
MET A  82
 None
 1.22A 5igvA-4o48A:
undetectable		 5igvA-4o48A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 10 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.18A 5lf3H-4o48A:
undetectable
5lf3I-4o48A:
2.8		 5lf3H-4o48A:
22.51
5lf3I-4o48A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 10 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.19A 5lf3V-4o48A:
undetectable
5lf3W-4o48A:
undetectable		 5lf3V-4o48A:
22.51
5lf3W-4o48A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 GLY A 222
VAL A 190
ILE A 267
GLY A 206
SER A 200
 ASP  A 402 (-3.3A)
None
None
None
ASP  A 402 ( 4.2A)
 1.16A 6c2mB-4o48A:
undetectable		 6c2mB-4o48A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4o48 UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 LYS A 293
VAL A 305
ASP A 307
 None
 0.61A 6fgdA-4o48A:
undetectable		 6fgdA-4o48A:
21.86