SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		4 / 8 PHE A 152
PHE A  18
ARG A 186
LEU A  72
 None
 1.16A 1x8vA-4o4oA:
undetectable		 1x8vA-4o4oA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		4 / 7 PHE A 152
PHE A 159
ILE A  81
ASN A  83
 None
 0.93A 2zseA-4o4oA:
undetectable		 2zseA-4o4oA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		4 / 7 VAL A  49
VAL A  53
ILE A  81
ARG A  12
 None
 0.91A 3ms9B-4o4oA:
undetectable		 3ms9B-4o4oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		4 / 6 VAL A  49
VAL A  53
ILE A  81
ARG A  12
 None
 1.10A 3pyyA-4o4oA:
undetectable		 3pyyA-4o4oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE A  51
ILE A   7
ILE A 196
GLY A  48
VAL A 194
 None
 1.04A 3rukB-4o4oA:
undetectable		 3rukB-4o4oA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		3 / 3 PRO A  64
ASP A  63
GLU A  90
 None
 0.85A 3v4tC-4o4oA:
undetectable		 3v4tC-4o4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4o4o PHYCOCYANOBILIN
LYASE CPCT
(Nostoc
sp.
PCC
7120) 		4 / 8 VAL A  36
HIS A 188
ASN A 189
GLU A 193
 None
 1.08A 6gneB-4o4oA:
undetectable		 6gneB-4o4oA:
16.50