SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 8 GLY A 445
GLY A 530
LEU A 510
GLY A 512
 None
 0.78A 1jhaA-4o4xA:
undetectable		 1jhaA-4o4xA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 5 PHE A 199
LEU A 212
PHE A 231
SER A 257
 None
 1.21A 1wrkB-4o4xA:
undetectable		 1wrkB-4o4xA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4o4x TBPB
(Glaesserella
parasuis) 		3 / 3 SER A 286
GLU A 103
ASP A  98
 None
None
GOL  A 601 ( 4.4A)
 0.89A 2avdB-4o4xA:
undetectable		 2avdB-4o4xA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 PHE A 529
TYR A 503
ARG A 298
GLY A 500
 None
None
GOL  A 603 (-4.1A)
GOL  A 603 ( 4.3A)
 1.49A 2i30A-4o4xA:
undetectable		 2i30A-4o4xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 9 GLY A 178
ILE A 114
VAL A  53
PRO A  54
VAL A  50
 None
 1.35A 2nnhB-4o4xA:
undetectable		 2nnhB-4o4xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 9 ALA A 235
ALA A 237
SER A 252
SER A 255
ALA A 276
 None
 1.46A 2vh3A-4o4xA:
undetectable		 2vh3A-4o4xA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4o4x TBPB
(Glaesserella
parasuis) 		3 / 3 ARG A  62
VAL A  53
THR A 153
 None
 0.73A 3cyxA-4o4xA:
undetectable		 3cyxA-4o4xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 11 GLY A 366
ASP A 408
ALA A 422
THR A 421
ALA A 353
 None
 1.03A 3g88A-4o4xA:
undetectable		 3g88A-4o4xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 11 GLY A 366
ASP A 408
ALA A 422
THR A 421
ALA A 353
 None
 1.04A 3g88B-4o4xA:
undetectable		 3g88B-4o4xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 SER A 252
PHE A 250
ASP A 155
PRO A 165
 None
 1.44A 3jqaA-4o4xA:
undetectable		 3jqaA-4o4xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 SER A 252
PHE A 250
ASP A 155
PRO A 165
 None
 1.39A 3jqaB-4o4xA:
undetectable		 3jqaB-4o4xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 SER A 252
PHE A 250
ASP A 155
PRO A 165
 None
 1.41A 3jqaD-4o4xA:
undetectable		 3jqaD-4o4xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 7 PHE A 529
GLY A 530
GLY A 501
PHE A 457
 None
 0.97A 3ko0M-4o4xA:
undetectable
3ko0P-4o4xA:
undetectable		 3ko0M-4o4xA:
11.09
3ko0P-4o4xA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 12 PHE A 250
TYR A 248
ILE A  65
PHE A 152
PHE A 282
 None
 1.37A 3ndiA-4o4xA:
undetectable		 3ndiA-4o4xA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 12 ARG A  62
ASN A 157
GLY A 182
GLU A  41
ASN A  67
 None
 0.96A 3v3oB-4o4xA:
undetectable		 3v3oB-4o4xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 10 ASP A 464
PHE A 438
ASN A 442
GLY A 399
GLY A 465
 None
 1.33A 3v3oD-4o4xA:
undetectable		 3v3oD-4o4xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4o4x TBPB
(Glaesserella
parasuis) 		3 / 3 LYS A 189
PRO A 190
SER A 191
 None
SO4  A 612 ( 4.1A)
None
 0.48A 4k50I-4o4xA:
undetectable		 4k50I-4o4xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4o4x TBPB
(Glaesserella
parasuis) 		3 / 3 GLY A 445
GLU A 433
THR A 432
 None
 0.59A 4kouA-4o4xA:
undetectable		 4kouA-4o4xA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4o4x TBPB
(Glaesserella
parasuis) 		5 / 12 GLY A 470
ASP A 495
ILE A 463
ASN A 442
GLY A 467
 None
 0.98A 4obwC-4o4xA:
undetectable		 4obwC-4o4xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 7 ALA A 235
THR A 236
ALA A 237
MET A 208
 None
 1.03A 4qw0K-4o4xA:
undetectable		 4qw0K-4o4xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 7 ALA A 235
THR A 236
ALA A 237
MET A 208
 None
 1.03A 4qw0Y-4o4xA:
undetectable		 4qw0Y-4o4xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 7 ALA A 472
SER A 412
GLY A 526
ALA A 527
 None
 0.87A 4r1zB-4o4xA:
undetectable		 4r1zB-4o4xA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 7 THR A  72
GLY A  48
ARG A 230
ALA A  70
 SO4  A 607 (-3.2A)
None
None
None
 0.91A 4txnA-4o4xA:
undetectable		 4txnA-4o4xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 GLY A 131
TYR A 129
ALA A 271
ARG A 230
 None
 1.26A 4yshB-4o4xA:
undetectable		 4yshB-4o4xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 5 ASP A 187
VAL A  55
GLY A 178
ALA A 156
 None
 0.83A 5hwaA-4o4xA:
undetectable		 5hwaA-4o4xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.07A 5igyA-4o4xA:
undetectable		 5igyA-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.15A 5ih0A-4o4xA:
undetectable		 5ih0A-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4o4x TBPB
(Glaesserella
parasuis) 		4 / 6 PHE A 468
GLY A 501
GLN A 513
TYR A 503
 None
None
GOL  A 603 (-4.3A)
None
 1.22A 6ag0A-4o4xA:
undetectable		 6ag0A-4o4xA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4o4x TBPB
(Glaesserella
parasuis) 		3 / 3 ARG A 389
PHE A 365
PHE A 468
 None
 1.03A 6nknC-4o4xA:
undetectable
6nknJ-4o4xA:
undetectable		 6nknC-4o4xA:
18.55
6nknJ-4o4xA:
6.60