SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		5 / 10 ASP H  77
ILE H  47
GLY H  48
GLY H  49
ILE H  50
 None
 0.84A 1sdtA-4o4yH:
undetectable		 1sdtA-4o4yH:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		5 / 11 ASP H  77
ILE H  47
GLY H  48
GLY H  49
ILE H  50
 None
 0.85A 1sduA-4o4yH:
undetectable		 1sduA-4o4yH:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		5 / 10 ASP H  77
ILE H  47
GLY H  48
GLY H  49
ILE H  50
 None
 0.85A 1sdvA-4o4yH:
undetectable		 1sdvA-4o4yH:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 5 LEU H 109
GLN H  38
THR H  90
GLU H 149
 None
 1.29A 3n58C-4o4yH:
undetectable		 3n58C-4o4yH:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 5 SER H 113
ALA H 115
PHE H 147
LEU H 171
 None
 0.37A 5mthA-4o4yH:
25.4		 5mthA-4o4yH:
52.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4o4y 2095-2 HEAVY CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		3 / 3 PRO H 186
SER H 188
SER H 189
 None
 0.42A 6bpyA-4o4yH:
undetectable		 6bpyA-4o4yH:
21.73