SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 7 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
None
None
 0.94A 1dssG-4o59O:
54.0		 1dssG-4o59O:
73.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		7 / 7 SER O 148
THR O 150
ASN O 152
CYH O 153
TYR O 311
ASN O 313
TYR O 317
 None
None
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
 0.17A 1dssG-4o59O:
54.0		 1dssG-4o59O:
73.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
None
None
 0.94A 1dssR-4o59O:
53.8		 1dssR-4o59O:
73.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		8 / 8 SER O 148
THR O 150
ASN O 152
CYH O 153
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 None
None
None
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
 0.36A 1dssR-4o59O:
53.8		 1dssR-4o59O:
73.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.03A 1n6cA-4o59O:
undetectable		 1n6cA-4o59O:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 5 LEU O 246
GLY O 166
HIS O 162
ILE O 161
 None
 0.70A 1xf1A-4o59O:
undetectable		 1xf1A-4o59O:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 6 LEU O 246
GLY O 166
HIS O 162
ILE O 161
 None
 0.66A 1xf1B-4o59O:
undetectable		 1xf1B-4o59O:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 12 ALA O  19
GLY O   4
TYR O  91
ILE O  82
ALA O  29
 None
 0.94A 2plwA-4o59O:
3.0		 2plwA-4o59O:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 7 MET O 328
VAL O 144
ILE O 117
TYR O 137
 None
 1.04A 2yfbA-4o59O:
undetectable		 2yfbA-4o59O:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
None
None
 0.96A 3dmtC-4o59O:
48.8		 3dmtC-4o59O:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		8 / 8 SER O 148
THR O 150
ASN O 152
CYH O 153
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 None
None
None
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.5A)
 0.30A 3dmtC-4o59O:
48.8		 3dmtC-4o59O:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 8 VAL O   3
PHE O  20
THR O  16
VAL O  93
 None
 1.15A 3fhxB-4o59O:
3.8		 3fhxB-4o59O:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 12 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
 0.97A 3hs6B-4o59O:
undetectable		 3hs6B-4o59O:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 6 THR O  96
ASN O   6
ASP O  32
ILE O  35
 NAD  O 401 (-4.2A)
NAD  O 401 (-3.5A)
NAD  O 401 (-2.7A)
None
 1.42A 3w9tB-4o59O:
undetectable		 3w9tB-4o59O:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		3 / 3 ASN O 236
ASP O 312
ASN O 313
 None
None
NAD  O 401 (-3.8A)
 0.75A 4agaA-4o59O:
undetectable		 4agaA-4o59O:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 12 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
 0.91A 4e1gA-4o59O:
undetectable		 4e1gA-4o59O:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.03A 4e47A-4o59O:
undetectable		 4e47A-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.04A 4e47B-4o59O:
undetectable		 4e47B-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.04A 4e47C-4o59O:
undetectable		 4e47C-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.02A 4jdsA-4o59O:
undetectable		 4jdsA-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.01A 4jdsB-4o59O:
undetectable		 4jdsB-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.04A 4jdsC-4o59O:
undetectable		 4jdsC-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 12 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 1.01A 4jlgA-4o59O:
undetectable		 4jlgA-4o59O:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		3 / 3 ILE O 117
MET O 130
ARG O 320
 None
 0.87A 4lnwA-4o59O:
undetectable		 4lnwA-4o59O:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		3 / 3 ILE O 117
MET O 130
ARG O 320
 None
 0.87A 4lnxA-4o59O:
undetectable		 4lnxA-4o59O:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 12 VAL O 259
ALA O 262
PHE O 292
SER O 290
GLY O 272
 None
 1.35A 4mm4A-4o59O:
undetectable		 4mm4A-4o59O:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 6 ASP O 195
ALA O 199
THR O 181
THR O 179
 None
None
None
NAD  O 401 ( 4.9A)
 1.47A 4z4cA-4o59O:
undetectable		 4z4cA-4o59O:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 5 ASP O 195
ALA O 199
THR O 181
THR O 179
 None
None
None
NAD  O 401 ( 4.9A)
 1.49A 4z4gA-4o59O:
undetectable		 4z4gA-4o59O:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		5 / 11 ILE O 308
ALA O 296
GLY O 295
GLU O 275
LYS O 256
 None
 0.99A 5ayfA-4o59O:
undetectable		 5ayfA-4o59O:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		3 / 3 THR O 151
ALA O 147
ASN O 152
 None
 0.54A 5ersA-4o59O:
4.3		 5ersA-4o59O:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 7 VAL O 305
LEU O 307
ALA O 299
LEU O 246
 None
 0.58A 5jq7A-4o59O:
undetectable		 5jq7A-4o59O:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 6 PHE O 230
VAL O 175
ALA O 229
THR O 150
 None
 1.01A 5t7bA-4o59O:
undetectable		 5t7bA-4o59O:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		4 / 7 THR O 179
ARG O 231
ASP O 195
LEU O 192
 NAD  O 401 ( 4.9A)
None
None
None
 1.23A 5uxcA-4o59O:
undetectable		 5uxcA-4o59O:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bos
taurus) 		3 / 3 ARG O  17
HIS O  50
ARG O  10
 None
 1.17A 6dwdD-4o59O:
undetectable		 6dwdD-4o59O:
21.98