SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 1.02A 1fm6A-4o5aA:
undetectable		 1fm6A-4o5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 1.04A 1fm6U-4o5aA:
undetectable		 1fm6U-4o5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 0.94A 1xdkE-4o5aA:
undetectable		 1xdkE-4o5aA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		4 / 4 LEU A  96
PRO A 166
ILE A 316
LEU A 313
 None
 0.99A 1ya4B-4o5aA:
2.1		 1ya4B-4o5aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		4 / 4 LEU A  96
PRO A 166
ILE A 316
LEU A 313
 None
 0.94A 1ya4C-4o5aA:
2.4		 1ya4C-4o5aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 11 ALA A 309
ALA A 308
GLN A 310
LEU A 307
ALA A  95
 None
None
SO4  A 404 (-3.4A)
None
None
 1.04A 2aclE-4o5aA:
undetectable		 2aclE-4o5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		4 / 4 VAL A 324
LEU A  96
ILE A  68
LEU A 131
 None
 0.93A 2byoA-4o5aA:
undetectable		 2byoA-4o5aA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 9 LEU A 297
ILE A 279
ILE A 251
ALA A 175
LEU A 331
 None
 1.04A 2m9qA-4o5aA:
undetectable		 2m9qA-4o5aA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 173
GLY A 201
LEU A 200
ASP A 172
SER A 160
 None
 1.16A 2nv4A-4o5aA:
undetectable		 2nv4A-4o5aA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 173
GLY A 201
LEU A 200
ASP A 172
SER A 160
 None
 1.18A 2nv4B-4o5aA:
undetectable		 2nv4B-4o5aA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 SER A 284
MET A 286
ARG A 193
VAL A 194
ASP A 255
 GOL  A 403 (-4.7A)
None
OCS  A 223 ( 4.9A)
None
None
 1.46A 3jayA-4o5aA:
undetectable		 3jayA-4o5aA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
 None
None
SO4  A 404 (-3.4A)
None
None
 1.17A 4nqaH-4o5aA:
undetectable		 4nqaH-4o5aA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 0.98A 4nqaH-4o5aA:
undetectable		 4nqaH-4o5aA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 11 ALA A 258
VAL A 256
GLY A 196
VAL A 194
SER A 232
 None
 1.16A 4xnxA-4o5aA:
undetectable		 4xnxA-4o5aA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		5 / 12 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 0.95A 5z12B-4o5aA:
undetectable		 5z12B-4o5aA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		6 / 12 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
LEU A 133
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.47A 5z12C-4o5aA:
undetectable		 5z12C-4o5aA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		6 / 12 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
ILE A  85
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.32A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR
(Bifidobacterium
animalis) 		6 / 12 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
LEU A 133
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.31A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88