SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 187
LEU A 180
LEU A 181
LEU A  93
ILE A  97
 None
 1.12A 1fmlB-4o5hA:
undetectable		 1fmlB-4o5hA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 280
ALA A 455
GLY A 456
LEU A 434
PHE A 472
 None
 1.28A 1vpoH-4o5hA:
undetectable
1vpoL-4o5hA:
undetectable		 1vpoH-4o5hA:
19.25
1vpoL-4o5hA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ASP A 291
ASP A 289
VAL A 288
GLY A 324
ILE A 326
 None
 1.14A 3ektD-4o5hA:
undetectable		 3ektD-4o5hA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 GLU A 203
TRP A 176
LYS A 114
ASN A 177
 None
 1.33A 3k8mA-4o5hA:
2.0		 3k8mA-4o5hA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 GLU A 203
TRP A 176
LYS A 114
ASN A 177
 None
 1.33A 3k8mB-4o5hA:
undetectable		 3k8mB-4o5hA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 250
ILE A 261
LEU A 276
GLY A 253
TYR A 432
 None
 1.04A 3nrrA-4o5hA:
3.0		 3nrrA-4o5hA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 250
ILE A 261
LEU A 276
GLY A 253
TYR A 432
 None
 1.02A 3nrrB-4o5hA:
3.0		 3nrrB-4o5hA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ILE A 246
ILE A 187
ILE A 216
ASN A 227
VAL A  66
 None
 1.35A 3ohtA-4o5hA:
undetectable
3ohtB-4o5hA:
undetectable		 3ohtA-4o5hA:
21.47
3ohtB-4o5hA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 11 ASN A 177
PHE A 178
LEU A 181
MET A 182
TRP A 185
CYH A 309
 None
 0.34A 4fr8A-4o5hA:
56.1		 4fr8A-4o5hA:
44.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ASN A 177
PHE A 178
MET A 182
TRP A 185
PHE A 472
 None
 1.39A 4fr8A-4o5hA:
56.1		 4fr8A-4o5hA:
44.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 PHE A 178
LEU A 181
MET A 182
TRP A 185
SER A 464
 None
 1.20A 4fr8A-4o5hA:
56.1		 4fr8A-4o5hA:
44.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 180
ALA A 128
ILE A 187
ALA A 188
ILE A 216
 None
 0.97A 4o2bD-4o5hA:
undetectable		 4o2bD-4o5hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLY A 349
PRO A 350
GLN A 307
 None
 0.35A 4oltB-4o5hA:
undetectable		 4oltB-4o5hA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLY A 349
PRO A 350
GLN A 307
 None
 0.28A 4qwpB-4o5hA:
undetectable		 4qwpB-4o5hA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 VAL A 116
LEU A  11
GLU A 106
LEU A 110
THR A  15
 None
 1.28A 4zmeB-4o5hA:
undetectable		 4zmeB-4o5hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 215
PHE A 131
ILE A 216
 None
 0.69A 5dzk1-4o5hA:
undetectable
5dzkF-4o5hA:
2.9
5dzkM-4o5hA:
undetectable		 5dzk1-4o5hA:
10.00
5dzkF-4o5hA:
17.73
5dzkM-4o5hA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 215
PHE A 131
ILE A 216
ILE A 187
 None
 0.86A 5dzk4-4o5hA:
undetectable
5dzkg-4o5hA:
2.9
5dzkm-4o5hA:
undetectable
5dzkn-4o5hA:
undetectable		 5dzk4-4o5hA:
10.00
5dzkg-4o5hA:
17.73
5dzkm-4o5hA:
17.03
5dzkn-4o5hA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 172
VAL A 197
LEU A 199
LEU A 212
VAL A 226
 None
 1.22A 5eb5A-4o5hA:
undetectable		 5eb5A-4o5hA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 12 ASN A 177
PHE A 178
LEU A 181
MET A 182
TRP A 185
CYH A 309
 None
 0.79A 5fhzA-4o5hA:
54.1		 5fhzA-4o5hA:
44.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 12 ASN A 177
PHE A 178
LEU A 181
MET A 182
TRP A 185
THR A 310
 None
 0.61A 5fhzA-4o5hA:
54.1		 5fhzA-4o5hA:
44.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 177
MET A 182
TRP A 185
CYH A 309
THR A 310
 None
 0.92A 5fhzD-4o5hA:
54.5		 5fhzD-4o5hA:
44.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 364
GLY A 377
GLU A 406
ALA A 372
ILE A 301
 None
 1.14A 5ih0A-4o5hA:
undetectable		 5ih0A-4o5hA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLY A 168
ASP A 247
ASN A 268
 None
 0.54A 5jglA-4o5hA:
3.7		 5jglA-4o5hA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 8 ASP A 291
ASP A 289
VAL A 288
GLY A 324
ILE A 326
 None
 1.16A 5kr1B-4o5hA:
undetectable		 5kr1B-4o5hA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 THR A 139
THR A  83
ARG A  86
 None
 1.05A 5wm2A-4o5hA:
2.5		 5wm2A-4o5hA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A 213
LEU A 215
VAL A 124
ALA A 127
LEU A 104
 None
 1.11A 6czmA-4o5hA:
undetectable
6czmC-4o5hA:
undetectable		 6czmA-4o5hA:
23.08
6czmC-4o5hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A 278
SER A 280
ASN A 177
VAL A 308
 None
 0.96A 6giqL-4o5hA:
undetectable
6giqP-4o5hA:
undetectable
6giqT-4o5hA:
undetectable		 6giqL-4o5hA:
23.98
6giqP-4o5hA:
18.47
6giqT-4o5hA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 ALA A 330
ALA A 333
ALA A 376
ALA A 375
 None
 0.76A 6gtqA-4o5hA:
0.0
6gtqB-4o5hA:
0.0		 6gtqA-4o5hA:
18.11
6gtqB-4o5hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4o5h PHENYLACETALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 ALA A 376
ALA A 375
ALA A 330
ALA A 333
 None
 0.75A 6gtqA-4o5hA:
0.0
6gtqB-4o5hA:
0.0		 6gtqA-4o5hA:
18.11
6gtqB-4o5hA:
18.11