SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 9 GLU A  44
ARG A  23
ILE A  24
ALA A  28
ILE A  83
 None
 1.44A 1aj6A-4o5mA:
undetectable		 1aj6A-4o5mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 8 TYR A  87
HIS A  90
SER A  91
VAL A  95
 None
 0.92A 1jtvA-4o5mA:
undetectable		 1jtvA-4o5mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  85
LEU A  93
ILE A 157
ILE A 361
LEU A 358
 None
 1.24A 1tw4B-4o5mA:
undetectable		 1tw4B-4o5mA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
 0.74A 1w2zA-4o5mA:
undetectable		 1w2zA-4o5mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 11 LEU A  48
ALA A  72
GLY A  84
ILE A  83
VAL A  50
 None
 0.98A 2fxdA-4o5mA:
undetectable		 2fxdA-4o5mA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 8 ILE A  83
GLY A  84
PHE A  45
PHE A  19
 None
 0.79A 2vctC-4o5mA:
undetectable		 2vctC-4o5mA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.77A 2y69N-4o5mA:
2.1		 2y69N-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 5 ILE A 157
PRO A 161
VAL A  16
PHE A  37
 None
 1.16A 2ygnA-4o5mA:
undetectable		 2ygnA-4o5mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 ILE A  83
ILE A  24
PHE A  19
PHE A  37
VAL A 120
 None
 0.99A 2ygoA-4o5mA:
undetectable		 2ygoA-4o5mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.73A 2zxwA-4o5mA:
2.0		 2zxwA-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.75A 2zxwN-4o5mA:
2.3		 2zxwN-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.73A 3ablN-4o5mA:
2.0		 3ablN-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.72A 3abmN-4o5mA:
undetectable		 3abmN-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.74A 3asoA-4o5mA:
1.9		 3asoA-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 ARG A 100
VAL A 302
THR A 312
 None
 0.29A 3cyxA-4o5mA:
undetectable		 3cyxA-4o5mA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 9 LEU A 352
GLY A  84
ILE A  83
ALA A 256
ILE A 253
 None
 0.97A 3el0B-4o5mA:
undetectable		 3el0B-4o5mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  12
ARG A  78
GLU A  74
ARG A 296
TYR A 300
 None
 1.41A 3k39B-4o5mA:
undetectable		 3k39B-4o5mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  12
ARG A  78
GLU A  74
ARG A 296
TYR A 300
 None
 1.41A 3k39H-4o5mA:
undetectable		 3k39H-4o5mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  12
ARG A  78
GLU A  74
ARG A 296
TYR A 300
 None
 1.42A 3k39M-4o5mA:
undetectable		 3k39M-4o5mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 8 ILE A  83
GLY A  84
SER A  91
ASN A 159
 None
 0.95A 3lslA-4o5mA:
undetectable
3lslD-4o5mA:
undetectable		 3lslA-4o5mA:
21.07
3lslD-4o5mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 8 SER A  91
ASN A 159
ILE A  83
GLY A  84
 None
 0.95A 3lslA-4o5mA:
undetectable
3lslD-4o5mA:
undetectable		 3lslA-4o5mA:
21.07
3lslD-4o5mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 GLY A  84
GLY A 249
PHE A  19
SER A  86
GLU A  44
 None
 1.27A 3tkaA-4o5mA:
undetectable		 3tkaA-4o5mA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 7 ILE A 373
THR A 312
THR A 311
TYR A 241
 None
 0.88A 3tneB-4o5mA:
undetectable		 3tneB-4o5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 11 ILE A  53
ALA A  11
LEU A  12
THR A  15
VAL A  16
 None
 1.07A 4g1bB-4o5mA:
3.6		 4g1bB-4o5mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 TYR A 300
HIS A   0
ARG A  13
 None
 1.11A 4htfA-4o5mA:
undetectable		 4htfA-4o5mA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 9 ALA A 327
ALA A 331
GLY A 248
GLY A 249
ASP A 355
 None
 1.20A 4qwuK-4o5mA:
undetectable
4qwuL-4o5mA:
undetectable		 4qwuK-4o5mA:
20.73
4qwuL-4o5mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 THR A 158
ALA A  89
ASN A 159
 None
 0.35A 5ersA-4o5mA:
undetectable		 5ersA-4o5mA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 5 GLY A 350
THR A 349
GLY A 160
LEU A 358
 None
 0.88A 5jlcA-4o5mA:
undetectable		 5jlcA-4o5mA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 MET A 330
THR A 328
GLY A 252
ALA A 256
ASP A 259
 None
 1.23A 5kvaA-4o5mA:
undetectable		 5kvaA-4o5mA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		5 / 12 MET A 330
THR A 328
GLY A 252
ALA A 256
ASP A 259
 None
 1.19A 5kvaB-4o5mA:
undetectable		 5kvaB-4o5mA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.74A 5z84A-4o5mA:
2.1		 5z84A-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.74A 5z86A-4o5mA:
2.1		 5z86A-4o5mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 6 GLY A  84
GLY A 249
PRO A 250
GLY A 252
 None
 0.70A 6ag0C-4o5mA:
undetectable		 6ag0C-4o5mA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		4 / 7 ARG A  13
ALA A  11
ILE A  71
ALA A  72
 None
 0.62A 6ma7A-4o5mA:
undetectable		 6ma7A-4o5mA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o5m ISOVALERYL-COA
DEHYDROGENASE
(Brucella
suis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 None
 0.76A 6nknA-4o5mA:
2.0		 6nknA-4o5mA:
22.39