SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 VAL A  39
LYS A  40
HIS A  50
 None
 0.91A 3elzA-4o5vA:
undetectable		 3elzA-4o5vA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ARG A  62
GLY A  63
ILE A  60
GLU A  61
 None
 1.08A 4g0vA-4o5vA:
2.1		 4g0vA-4o5vA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ILE A 203
ILE A 149
PHE A 173
LEU A 174
 None
 0.93A 4m51A-4o5vA:
undetectable		 4m51A-4o5vA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 GLY A  26
ILE A  18
LYS A  16
GLN A  19
 None
None
FE2  A 302 ( 4.3A)
None
 1.04A 4ma8C-4o5vA:
undetectable		 4ma8C-4o5vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ILE A 149
GLY A 131
ASN A 132
ILE A 160
 None
 0.77A 5j4nB-4o5vA:
undetectable		 5j4nB-4o5vA:
19.21