SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P9G_A_ACTA42_0 (EAFP 2)	4o64	LYSINE-SPECIFIC DEMETHYLASE 2B (Homo sapiens)	3 / 3	CYH A 624 ARG A 621 CYH A 646	ZN A2002 (-2.2A) None ZN A2002 (-2.3A)	1.44A	1p9gA-4o64A: undetectable	1p9gA-4o64A: 14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_E_CLME221_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4o64	LYSINE-SPECIFIC DEMETHYLASE 2B (Homo sapiens)	3 / 3	PHE A 629 CYH A 627 HIS A 628	None ZN A2002 (-2.3A) None	1.18A	3u9fF-4o64A: undetectable	3u9fF-4o64A: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_I_CLMI221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4o64	LYSINE-SPECIFIC DEMETHYLASE 2B (Homo sapiens)	3 / 3	PHE A 629 CYH A 627 HIS A 628	None ZN A2002 (-2.3A) None	1.21A	3u9fG-4o64A: undetectable	3u9fG-4o64A: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_R_CLMR221_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4o64	LYSINE-SPECIFIC DEMETHYLASE 2B (Homo sapiens)	3 / 3	PHE A 629 CYH A 627 HIS A 628	None ZN A2002 (-2.3A) None	1.18A	3u9fS-4o64A: undetectable	3u9fS-4o64A: 16.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P9G_A_ACTA42_0","EAFP 2","4o64","LYSINE-SPECIFIC DEMETHYLASE 2B","Homo sapiens",3,"CYH A 624;ARG A 621;CYH A 646"," ZN A2002 (-2.2A);None; ZN A2002 (-2.3A)","1.44A","1p9gA-4o64A:undetectable","1p9gA-4o64A:14.41"],["3U9F_E_CLME221_1","CHLORAMPHENICOL ACETYLTRANSFERASE","4o64","LYSINE-SPECIFIC DEMETHYLASE 2B","Homo sapiens",3,"PHE A 629;CYH A 627;HIS A 628","None; ZN A2002 (-2.3A);None","1.18A","3u9fF-4o64A:undetectable","3u9fF-4o64A:16.44"],["3U9F_I_CLMI221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","4o64","LYSINE-SPECIFIC DEMETHYLASE 2B","Homo sapiens",3,"PHE A 629;CYH A 627;HIS A 628","None; ZN A2002 (-2.3A);None","1.21A","3u9fG-4o64A:undetectable","3u9fG-4o64A:16.44"],["3U9F_R_CLMR221_1","CHLORAMPHENICOL ACETYLTRANSFERASE","4o64","LYSINE-SPECIFIC DEMETHYLASE 2B","Homo sapiens",3,"PHE A 629;CYH A 627;HIS A 628","None; ZN A2002 (-2.3A);None","1.18A","3u9fS-4o64A:undetectable","3u9fS-4o64A:16.44"]]