SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.31A 1c9sB-4o6iA:
undetectable
1c9sC-4o6iA:
undetectable		 1c9sB-4o6iA:
13.91
1c9sC-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 ILE A 543
GLN A 397
LEU A 446
PRO A 447
LEU A 452
 None
 0.90A 1df7A-4o6iA:
undetectable		 1df7A-4o6iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 9 LEU A 544
ILE A 543
ASN A 542
LEU A 520
GLY A 401
 None
 1.04A 1e7aA-4o6iA:
undetectable		 1e7aA-4o6iA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 11 GLY A 385
HIS A 424
ALA A 519
ILE A 383
ARG A 485
 None
 1.31A 1gtfU-4o6iA:
undetectable
1gtfV-4o6iA:
undetectable		 1gtfU-4o6iA:
13.91
1gtfV-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 11 GLY A 385
HIS A 424
ALA A 519
ILE A 383
ARG A 485
 None
 1.29A 1utdM-4o6iA:
undetectable
1utdN-4o6iA:
undetectable		 1utdM-4o6iA:
13.91
1utdN-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 6 HIS A 517
HIS A 502
GLU A 392
ASP A 522
 None
ZN  A 601 (-3.2A)
ZN  A 601 (-2.4A)
MG  A 602 (-3.1A)
 1.25A 4apjA-4o6iA:
undetectable
4apjP-4o6iA:
undetectable		 4apjA-4o6iA:
16.33
4apjP-4o6iA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		3 / 3 TRP A 380
GLN A 402
THR A 379
 IMD  A 606 (-4.3A)
None
None
 0.93A 4m2xA-4o6iA:
undetectable		 4m2xA-4o6iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 GLU A 392
ASP A 389
LEU A 428
LEU A 431
HIS A 424
 ZN  A 601 (-2.4A)
None
None
None
None
 1.26A 4pgfB-4o6iA:
undetectable		 4pgfB-4o6iA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eeuD-4o6iA:
undetectable
5eeuE-4o6iA:
undetectable		 5eeuD-4o6iA:
13.91
5eeuE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.29A 5eeuH-4o6iA:
undetectable
5eeuI-4o6iA:
undetectable		 5eeuH-4o6iA:
13.91
5eeuI-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eeuJ-4o6iA:
undetectable
5eeuK-4o6iA:
undetectable		 5eeuJ-4o6iA:
13.91
5eeuK-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eevD-4o6iA:
undetectable
5eevE-4o6iA:
undetectable		 5eevD-4o6iA:
13.91
5eevE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eevJ-4o6iA:
undetectable
5eevK-4o6iA:
undetectable		 5eevJ-4o6iA:
13.91
5eevK-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eewD-4o6iA:
undetectable
5eewE-4o6iA:
undetectable		 5eewD-4o6iA:
13.91
5eewE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eewH-4o6iA:
undetectable
5eewI-4o6iA:
undetectable		 5eewH-4o6iA:
13.91
5eewI-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eewJ-4o6iA:
undetectable
5eewK-4o6iA:
undetectable		 5eewJ-4o6iA:
13.91
5eewK-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eexD-4o6iA:
undetectable
5eexE-4o6iA:
undetectable		 5eexD-4o6iA:
13.91
5eexE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eexH-4o6iA:
undetectable
5eexI-4o6iA:
undetectable		 5eexH-4o6iA:
13.91
5eexI-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eexJ-4o6iA:
undetectable
5eexK-4o6iA:
undetectable		 5eexJ-4o6iA:
13.91
5eexK-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eeyD-4o6iA:
undetectable
5eeyE-4o6iA:
undetectable		 5eeyD-4o6iA:
13.91
5eeyE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.30A 5eeyJ-4o6iA:
undetectable
5eeyK-4o6iA:
undetectable		 5eeyJ-4o6iA:
13.91
5eeyK-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5eezD-4o6iA:
undetectable
5eezE-4o6iA:
undetectable		 5eezD-4o6iA:
13.91
5eezE-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5ef0D-4o6iA:
undetectable
5ef0E-4o6iA:
undetectable		 5ef0D-4o6iA:
13.91
5ef0E-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5ef1D-4o6iA:
undetectable
5ef1E-4o6iA:
undetectable		 5ef1D-4o6iA:
13.91
5ef1E-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5ef2D-4o6iA:
undetectable
5ef2E-4o6iA:
undetectable		 5ef2D-4o6iA:
13.91
5ef2E-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 10 ARG A 485
GLY A 385
HIS A 424
ALA A 519
ILE A 383
 None
 1.28A 5ef3D-4o6iA:
undetectable
5ef3E-4o6iA:
undetectable		 5ef3D-4o6iA:
13.91
5ef3E-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		3 / 3 PRO A 535
ARG A 533
GLU A 527
 None
None
IMD  A 606 (-3.2A)
 0.76A 5j6hA-4o6iA:
undetectable		 5j6hA-4o6iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 8 ILE A 404
VAL A 442
TYR A 407
ILE A 549
 None
 0.74A 5mzrE-4o6iA:
undetectable		 5mzrE-4o6iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4o6i NUCLEOPROTEIN
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 4 LEU A 358
LEU A 366
SER A 440
ALA A 445
 None
 1.02A 5uunA-4o6iA:
undetectable		 5uunA-4o6iA:
21.19