SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 11 HIS A 210
ASP A 214
PHE A 182
ASP A 235
LEU A 234
 None
CA  A 401 (-2.7A)
None
CA  A 401 (-2.2A)
None
 1.39A 1c3sA-4o6mA:
undetectable		 1c3sA-4o6mA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A  51
ALA A   4
PHE A  34
VAL A  36
 None
 0.81A 1epbB-4o6mA:
undetectable		 1epbB-4o6mA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ARG A 304
GLY A 279
GLY A 236
 None
SO4  A 411 (-2.6A)
None
None
 0.84A 1jr1B-4o6mA:
undetectable		 1jr1B-4o6mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 246
GLY A 265
ALA A 325
ILE A 324
PRO A 317
 None
None
MPG  A 407 ( 3.9A)
None
None
 1.14A 1vq1A-4o6mA:
undetectable		 1vq1A-4o6mA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 223
ALA A 126
LEU A 129
SER A 132
LEU A 131
 None
 1.35A 2c12F-4o6mA:
1.5		 2c12F-4o6mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  72
ALA A 115
ILE A  59
LYS A  70
 None
 0.99A 2othA-4o6mA:
undetectable		 2othA-4o6mA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 ILE A  59
TYR A  12
ARG A  22
THR A  20
 None
 1.37A 3abkN-4o6mA:
undetectable
3abkW-4o6mA:
undetectable		 3abkN-4o6mA:
20.87
3abkW-4o6mA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 PHE A  34
LEU A  64
PHE A  82
LEU A  72
 None
 1.00A 3i45A-4o6mA:
undetectable		 3i45A-4o6mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 335
ARG A 304
ILE A 151
PHE A 303
 None
SO4  A 411 (-2.6A)
None
None
 1.08A 3ln1C-4o6mA:
1.8		 3ln1C-4o6mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 335
ARG A 304
ILE A 151
PHE A 303
 None
SO4  A 411 (-2.6A)
None
None
 1.08A 3ln1D-4o6mA:
undetectable		 3ln1D-4o6mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 LYS A 148
SER A 211
ASP A 243
ASP A 235
 SO4  A 411 (-4.9A)
None
None
CA  A 401 (-2.2A)
 1.23A 3n2oC-4o6mA:
3.0
3n2oD-4o6mA:
3.2		 3n2oC-4o6mA:
21.32
3n2oD-4o6mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A   9
ILE A  11
TYR A  12
LEU A  21
LEU A  60
 None
 1.23A 3vn2A-4o6mA:
undetectable		 3vn2A-4o6mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 250
LEU A 305
ILE A 207
ALA A 203
ILE A 323
 None
 1.07A 3vrmA-4o6mA:
undetectable		 3vrmA-4o6mA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 235
ARG A 304
THR A 178
 CA  A 401 (-2.2A)
SO4  A 411 (-2.6A)
None
 0.76A 4i13A-4o6mA:
undetectable		 4i13A-4o6mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A   3
ALA A   4
LEU A  42
ILE A  99
LEU A  95
 None
 1.06A 4j24D-4o6mA:
undetectable		 4j24D-4o6mA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 271
GLY A 265
THR A 251
LEU A 254
THR A 200
 None
 0.99A 4n49A-4o6mA:
undetectable		 4n49A-4o6mA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 235
ARG A 304
THR A 178
 CA  A 401 (-2.2A)
SO4  A 411 (-2.6A)
None
 0.79A 4p3rA-4o6mA:
undetectable		 4p3rA-4o6mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 302
SER A 160
ASN A 156
GLY A 149
GLY A 215
 None
None
None
None
CA  A 401 ( 4.7A)
 1.23A 4pevB-4o6mA:
undetectable		 4pevB-4o6mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 221
ASP A 148
ARG A 301
GLY A 236
 None
CA  A 401 (-3.7A)
None
None
 0.89A 5bs8A-4o6mA:
undetectable
5bs8C-4o6mA:
undetectable
5bs8D-4o6mA:
undetectable		 5bs8A-4o6mA:
20.70
5bs8C-4o6mA:
20.70
5bs8D-4o6mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 221
ASP A 148
ARG A 301
GLY A 236
 None
CA  A 401 (-3.7A)
None
None
 0.86A 5bs8A-4o6mA:
undetectable
5bs8B-4o6mA:
undetectable
5bs8C-4o6mA:
undetectable		 5bs8A-4o6mA:
20.70
5bs8B-4o6mA:
21.88
5bs8C-4o6mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 221
ASP A 148
ARG A 301
GLY A 236
 None
CA  A 401 (-3.7A)
None
None
 0.86A 5btdA-4o6mA:
undetectable
5btdB-4o6mA:
undetectable
5btdC-4o6mA:
undetectable		 5btdA-4o6mA:
20.70
5btdB-4o6mA:
21.88
5btdC-4o6mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 221
ASP A 148
ARG A 301
GLY A 236
 None
CA  A 401 (-3.7A)
None
None
 0.90A 5btdA-4o6mA:
undetectable
5btdC-4o6mA:
undetectable
5btdD-4o6mA:
undetectable		 5btdA-4o6mA:
20.70
5btdC-4o6mA:
20.70
5btdD-4o6mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 221
ASP A 148
ARG A 301
GLY A 236
 None
CA  A 401 (-3.7A)
None
None
 0.82A 5btgA-4o6mA:
undetectable
5btgC-4o6mA:
undetectable
5btgD-4o6mA:
undetectable		 5btgA-4o6mA:
20.70
5btgC-4o6mA:
20.70
5btgD-4o6mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 210
ASP A 214
PHE A 182
ASP A 235
LEU A 234
 None
CA  A 401 (-2.7A)
None
CA  A 401 (-2.2A)
None
 1.44A 5ef8B-4o6mA:
undetectable		 5ef8B-4o6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 6 LYS A 148
ASP A 214
GLY A 215
ASP A 235
 SO4  A 411 (-4.9A)
CA  A 401 (-2.7A)
CA  A 401 ( 4.7A)
CA  A 401 (-2.2A)
 1.24A 5hp1A-4o6mA:
undetectable		 5hp1A-4o6mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 6 LYS A 148
ASP A 214
GLY A 215
ASP A 235
 SO4  A 411 (-4.9A)
CA  A 401 (-2.7A)
CA  A 401 ( 4.7A)
CA  A 401 (-2.2A)
 1.35A 5hp1C-4o6mA:
undetectable		 5hp1C-4o6mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A   2
PHE A  83
LEU A  66
 None
 0.69A 5x1bC-4o6mA:
2.1		 5x1bC-4o6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 ILE A  59
TYR A  12
ARG A  22
THR A  20
 None
 1.28A 5z84N-4o6mA:
1.8
5z84W-4o6mA:
undetectable		 5z84N-4o6mA:
20.87
5z84W-4o6mA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ILE A 246
ARG A 304
ARG A 301
 None
None
SO4  A 411 (-2.6A)
None
 1.20A 6hisA-4o6mA:
3.0
6hisB-4o6mA:
3.0		 6hisA-4o6mA:
12.82
6hisB-4o6mA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ILE A 246
ARG A 304
ARG A 301
 None
None
SO4  A 411 (-2.6A)
None
 1.20A 6hisB-4o6mA:
3.0
6hisC-4o6mA:
3.0		 6hisB-4o6mA:
12.82
6hisC-4o6mA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ILE A 246
ARG A 304
ARG A 301
 None
None
SO4  A 411 (-2.6A)
None
 1.20A 6hisC-4o6mA:
3.0
6hisD-4o6mA:
3.0		 6hisC-4o6mA:
12.82
6hisD-4o6mA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ILE A 246
ARG A 304
ARG A 301
 None
None
SO4  A 411 (-2.6A)
None
 1.20A 6hisD-4o6mA:
3.0
6hisE-4o6mA:
3.0		 6hisD-4o6mA:
12.82
6hisE-4o6mA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 243
ILE A 246
ARG A 304
ARG A 301
 None
None
SO4  A 411 (-2.6A)
None
 1.20A 6hisA-4o6mA:
3.0
6hisE-4o6mA:
3.0		 6hisA-4o6mA:
12.82
6hisE-4o6mA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 301
LEU A 305
PHE A 309
 None
 0.38A 6nknP-4o6mA:
2.1		 6nknP-4o6mA:
21.84