SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 107
GLY A 106
GLY A  49
SER A 103
 None
 0.93A 1eswA-4o6qA:
undetectable		 1eswA-4o6qA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.87A 1gtfL-4o6qA:
undetectable
1gtfM-4o6qA:
undetectable		 1gtfL-4o6qA:
18.72
1gtfM-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.87A 1gtfN-4o6qA:
undetectable
1gtfO-4o6qA:
undetectable		 1gtfN-4o6qA:
18.72
1gtfO-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  85
ALA A  75
PHE A  51
PHE A  46
 HEM  A 202 (-3.7A)
FMT  A 201 (-3.6A)
HEM  A 202 ( 4.9A)
None
 0.86A 2vcvL-4o6qA:
undetectable		 2vcvL-4o6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  20
TRP A  23
GLY A  95
 None
 0.41A 3l35A-4o6qA:
undetectable
3l35H-4o6qA:
undetectable		 3l35A-4o6qA:
10.40
3l35H-4o6qA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  20
TRP A  23
GLY A  95
 None
 0.45A 3l35B-4o6qA:
undetectable
3l35K-4o6qA:
undetectable		 3l35B-4o6qA:
10.40
3l35K-4o6qA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 139
TYR A 138
ALA A  57
TYR A  56
LEU A 119
 None
HEM  A 202 (-3.6A)
None
HEM  A 202 ( 3.7A)
None
 1.17A 3qxyA-4o6qA:
undetectable		 3qxyA-4o6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 139
TYR A 138
ALA A  57
TYR A  56
LEU A 119
 None
HEM  A 202 (-3.6A)
None
HEM  A 202 ( 3.7A)
None
 1.21A 3rc0A-4o6qA:
undetectable		 3rc0A-4o6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 139
TYR A 138
ALA A  57
TYR A  56
LEU A 119
 None
HEM  A 202 (-3.6A)
None
HEM  A 202 ( 3.7A)
None
 1.18A 3rc0B-4o6qA:
undetectable		 3rc0B-4o6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 143
SER A  24
TRP A  23
 None
 0.86A 4e7cD-4o6qA:
undetectable		 4e7cD-4o6qA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  20
GLY A 143
ASP A  64
THR A  97
VAL A 114
 None
 1.33A 5d0yA-4o6qA:
undetectable		 5d0yA-4o6qA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.85A 5eezL-4o6qA:
undetectable
5eezV-4o6qA:
undetectable		 5eezL-4o6qA:
18.72
5eezV-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.85A 5ef1L-4o6qA:
undetectable
5ef1V-4o6qA:
undetectable		 5ef1L-4o6qA:
18.72
5ef1V-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.85A 5ef2L-4o6qA:
undetectable
5ef2V-4o6qA:
undetectable		 5ef2L-4o6qA:
18.72
5ef2V-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		3 / 3 SER A  12
TYR A  11
TYR A   7
 None
 0.69A 5lakA-4o6qA:
undetectable
5lakI-4o6qA:
undetectable		 5lakA-4o6qA:
19.43
5lakI-4o6qA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		3 / 3 SER A  12
TYR A  11
TYR A   7
 None
 0.69A 5lakC-4o6qA:
undetectable
5lakJ-4o6qA:
undetectable		 5lakC-4o6qA:
19.43
5lakJ-4o6qA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		4 / 8 MET A 141
GLY A 131
SER A 123
VAL A 136
 HEM  A 202 (-3.6A)
None
None
None
 0.93A 6giqL-4o6qA:
undetectable
6giqP-4o6qA:
undetectable
6giqT-4o6qA:
undetectable		 6giqL-4o6qA:
19.09
6giqP-4o6qA:
21.52
6giqT-4o6qA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  45
GLY A  44
VAL A  37
ASN A  42
GLY A  40
 HEM  A 202 ( 4.4A)
None
HEM  A 202 ( 4.4A)
None
None
 0.83A 6gneA-4o6qA:
undetectable		 6gneA-4o6qA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4o6q HASAP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  45
GLY A  44
VAL A  37
ASN A  42
GLY A  40
 HEM  A 202 ( 4.4A)
None
HEM  A 202 ( 4.4A)
None
None
 0.84A 6gneB-4o6qA:
undetectable		 6gneB-4o6qA:
17.06