SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		4 / 4 ARG A  22
ALA A  21
ALA A  44
GLU A  46
 None
 1.20A 1e7bA-4o6vA:
undetectable		 1e7bA-4o6vA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		3 / 3 GLY A 199
ASP A 181
SER A 182
 None
 0.68A 3brfA-4o6vA:
undetectable		 3brfA-4o6vA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
VAL A 193
VAL A 208
ILE A 132
THR A 207
 None
 0.97A 3czhA-4o6vA:
undetectable		 3czhA-4o6vA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
VAL A 193
VAL A 208
ILE A 132
THR A 207
 None
 0.97A 3dl9A-4o6vA:
undetectable		 3dl9A-4o6vA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 10 ALA A  32
VAL A  66
ILE A  76
VAL A  80
PRO A 113
 None
 1.00A 3oxvB-4o6vA:
undetectable		 3oxvB-4o6vA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 ARG A  22
GLY A  40
GLY A  13
LEU A  34
GLU A  46
 None
 1.25A 3sxjA-4o6vA:
6.1		 3sxjA-4o6vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 GLY A  40
GLY A  13
LEU A  34
GLU A  46
ALA A  44
 None
 1.17A 3sxjA-4o6vA:
6.1		 3sxjA-4o6vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 ARG A  22
GLY A  40
GLY A  13
LEU A  34
GLU A  46
 None
 1.26A 3sxjB-4o6vA:
6.1		 3sxjB-4o6vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 GLY A  40
GLY A  13
LEU A  34
GLU A  46
ALA A  44
 None
 1.18A 3sxjB-4o6vA:
6.1		 3sxjB-4o6vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 ARG A  22
GLY A  40
GLY A  13
GLU A  46
ALA A  44
 None
 1.22A 3t7sB-4o6vA:
6.1		 3t7sB-4o6vA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 LEU A 224
ILE A 132
GLY A 178
ILE A 204
ALA A 135
 None
 1.18A 3uj7A-4o6vA:
undetectable		 3uj7A-4o6vA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 11 GLY A  54
ASP A  67
VAL A  66
ASN A  56
LEU A 116
 None
 1.08A 3v8vB-4o6vA:
6.5		 3v8vB-4o6vA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
ALA A 135
TRP A 136
SER A 201
VAL A 175
 None
 1.46A 4kyaB-4o6vA:
undetectable		 4kyaB-4o6vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
ALA A 135
TRP A 136
SER A 201
VAL A 175
 None
 1.45A 4kyaD-4o6vA:
undetectable		 4kyaD-4o6vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
ALA A 135
TRP A 136
SER A 201
VAL A 175
 None
 1.46A 4kyaF-4o6vA:
undetectable		 4kyaF-4o6vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 VAL A 226
ALA A 135
TRP A 136
SER A 201
VAL A 175
 None
 1.47A 4kyaH-4o6vA:
undetectable		 4kyaH-4o6vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 LEU A 211
VAL A 175
GLY A 229
THR A 207
THR A 231
 None
 1.42A 4mubA-4o6vA:
2.7		 4mubA-4o6vA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 ALA A  11
SER A  55
ILE A   9
GLY A  17
ASN A  81
 None
 1.26A 4obwA-4o6vA:
6.5		 4obwA-4o6vA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 GLY A 228
ILE A 204
VAL A 175
ILE A 132
THR A 207
 None
 0.97A 4q5mA-4o6vA:
undetectable		 4q5mA-4o6vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		3 / 3 THR A  10
ASN A  81
SER A  82
 None
 0.69A 4tvtA-4o6vA:
undetectable		 4tvtA-4o6vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
suis) 		5 / 12 LEU A  62
THR A 158
PHE A 157
LEU A 154
VAL A 117
 None
 1.47A 5dlvB-4o6vA:
undetectable		 5dlvB-4o6vA:
14.37