SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_C_MIYC392_1 (TETX2 PROTEIN)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	5 / 12	TYR A 70 VAL A 213 ILE A 214 ILE A 164 TYR A 165	HEM A 302 (-3.2A) None None HEM A 302 ( 4.9A) None	1.09A	4a99A-4o79A: undetectable 4a99C-4o79A: undetectable	4a99A-4o79A: 21.61 4a99C-4o79A: 21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O79_B_ASCB303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	4 / 6	LYS A 81 TYR A 140 ALA A 151 MET A 154	SO4 A 303 (-2.6A) HEM A 302 (-4.3A) None HEM A 302 (-3.8A)	0.31A	4o79B-4o79A: 36.0	4o79B-4o79A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O79_B_ASCB303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	4 / 6	LYS A 81 TYR A 140 ARG A 150 MET A 154	SO4 A 303 (-2.6A) HEM A 302 (-4.3A) SO4 A 303 (-3.8A) HEM A 302 (-3.8A)	1.26A	4o79B-4o79A: 36.0	4o79B-4o79A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O7G_A_ASCA303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	6 / 7	PHE A 105 HIS A 106 ILE A 111 TYR A 115 PHE A 182 ASN A 186	None HEM A 301 (-3.8A) None HEM A 301 ( 4.8A) None None	0.25A	4o7gA-4o79A: 36.9 4o7gB-4o79A: 36.0	4o7gA-4o79A: 100.00 4o7gB-4o79A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O7G_B_ASCB303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	4 / 6	LYS A 81 TYR A 140 ALA A 151 MET A 154	SO4 A 303 (-2.6A) HEM A 302 (-4.3A) None HEM A 302 (-3.8A)	0.29A	4o7gB-4o79A: 36.0	4o7gB-4o79A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O7G_B_ASCB304_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	6 / 6	PHE A 105 HIS A 106 ILE A 111 TYR A 115 PHE A 182 ASN A 186	None HEM A 301 (-3.8A) None HEM A 301 ( 4.8A) None None	0.43A	4o7gB-4o79A: 36.0	4o7gB-4o79A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ENT_C_MIYC901_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB,MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4o79	PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2 (Arabidopsis thaliana)	5 / 9	SER A 119 GLY A 110 GLU A 112 ASN A 113 ILE A 107	HEM A 301 (-4.4A) None None HEM A 301 (-3.7A) None	1.44A	5entC-4o79A: undetectable	5entC-4o79A: 15.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A99_C_MIYC392_1","TETX2 PROTEIN;TETX2 PROTEIN","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",5,"TYR A  70;VAL A 213;ILE A 214;ILE A 164;TYR A 165","HEM A 302 (-3.2A);None;None;HEM A 302 ( 4.9A);None","1.09A","4a99A-4o79A:undetectable;4a99C-4o79A:undetectable","4a99A-4o79A:21.61;4a99C-4o79A:21.61"],["4O79_B_ASCB303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",4,"LYS A  81;TYR A 140;ALA A 151;MET A 154","SO4 A 303 (-2.6A);HEM A 302 (-4.3A);None;HEM A 302 (-3.8A)","0.31A","4o79B-4o79A:36.0","4o79B-4o79A:100.00"],["4O79_B_ASCB303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",4,"LYS A  81;TYR A 140;ARG A 150;MET A 154","SO4 A 303 (-2.6A);HEM A 302 (-4.3A);SO4 A 303 (-3.8A);HEM A 302 (-3.8A)","1.26A","4o79B-4o79A:36.0","4o79B-4o79A:100.00"],["4O7G_A_ASCA303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",6,"PHE A 105;HIS A 106;ILE A 111;TYR A 115;PHE A 182;ASN A 186","None;HEM A 301 (-3.8A);None;HEM A 301 ( 4.8A);None;None","0.25A","4o7gA-4o79A:36.9;4o7gB-4o79A:36.0","4o7gA-4o79A:100.00;4o7gB-4o79A:100.00"],["4O7G_B_ASCB303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",4,"LYS A  81;TYR A 140;ALA A 151;MET A 154","SO4 A 303 (-2.6A);HEM A 302 (-4.3A);None;HEM A 302 (-3.8A)","0.29A","4o7gB-4o79A:36.0","4o7gB-4o79A:100.00"],["4O7G_B_ASCB304_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",6,"PHE A 105;HIS A 106;ILE A 111;TYR A 115;PHE A 182;ASN A 186","None;HEM A 301 (-3.8A);None;HEM A 301 ( 4.8A);None;None","0.43A","4o7gB-4o79A:36.0","4o7gB-4o79A:100.00"],["5ENT_C_MIYC901_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB,MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4o79","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","Arabidopsis thaliana",5,"SER A 119;GLY A 110;GLU A 112;ASN A 113;ILE A 107","HEM A 301 (-4.4A);None;None;HEM A 301 (-3.7A);None","1.44A","5entC-4o79A:undetectable","5entC-4o79A:15.71"]]