SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 290
HIS A 306
GLY A 310
ASN A 331
GLY A 337
 None
 1.14A 1ffyA-4o7dA:
undetectable		 1ffyA-4o7dA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 SER A 286
LYS A 289
ASN A 335
LYS A 481
SER A 482
GLY A 483
 ONL  A 601 (-1.4A)
ONL  A 601 ( 4.0A)
ONL  A 601 (-3.5A)
ONL  A 601 ( 4.8A)
None
ONL  A 601 (-3.5A)
 0.57A 1ghmA-4o7dA:
4.9		 1ghmA-4o7dA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 SER A 482
LEU A 505
TYR A 466
GLY A 487
 None
None
ONL  A 601 (-4.8A)
None
 1.41A 1liiA-4o7dA:
undetectable		 1liiA-4o7dA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 259
ASP A 277
LYS A 513
 None
 1.11A 1lqtB-4o7dA:
undetectable		 1lqtB-4o7dA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 259
ASP A 277
LYS A 513
 None
 1.09A 1lquB-4o7dA:
undetectable		 1lquB-4o7dA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.48A 1ru9H-4o7dA:
undetectable
1ru9L-4o7dA:
undetectable		 1ru9H-4o7dA:
19.75
1ru9L-4o7dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.48A 1ruaH-4o7dA:
undetectable
1ruaL-4o7dA:
undetectable		 1ruaH-4o7dA:
19.75
1ruaL-4o7dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 381
SER A 384
SER A 286
VAL A 288
TYR A 414
 ONL  A 601 (-2.8A)
None
ONL  A 601 (-1.4A)
None
ONL  A 601 (-4.7A)
 1.28A 1x70B-4o7dA:
undetectable		 1x70B-4o7dA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 295
ILE A 345
PHE A 413
VAL A 371
VAL A 422
 None
 1.04A 2ygoA-4o7dA:
undetectable		 2ygoA-4o7dA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 284
ALA A 366
VAL A 491
VAL A 358
ILE A 420
 None
 1.03A 3czhB-4o7dA:
undetectable		 3czhB-4o7dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 335
MET A 508
PHE A 318
 ONL  A 601 (-3.5A)
None
None
 1.14A 3g4lD-4o7dA:
undetectable		 3g4lD-4o7dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 451
GLY A 301
SER A 449
 None
 0.62A 4b53B-4o7dA:
undetectable		 4b53B-4o7dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A 338
THR A 342
VAL A 358
ILE A 345
 None
 0.98A 4xe3A-4o7dA:
undetectable		 4xe3A-4o7dA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0oA-4o7dA:
undetectable		 5n0oA-4o7dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0oB-4o7dA:
undetectable		 5n0oB-4o7dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.02A 5n0rA-4o7dA:
undetectable		 5n0rA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 0.99A 5n0sA-4o7dA:
undetectable		 5n0sA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.01A 5n0tA-4o7dA:
undetectable		 5n0tA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.01A 5n0tB-4o7dA:
undetectable		 5n0tB-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.03A 5n0wA-4o7dA:
undetectable		 5n0wA-4o7dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0wB-4o7dA:
undetectable		 5n0wB-4o7dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n0xA-4o7dA:
undetectable		 5n0xA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.03A 5n0xB-4o7dA:
undetectable		 5n0xB-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n4iA-4o7dA:
undetectable		 5n4iA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 250
ALA A 376
GLN A 379
ARG A 382
VAL A 484
CYH A 283
 None
None
None
None
ONL  A 601 (-3.7A)
None
 1.25A 5uanA-4o7dA:
undetectable		 5uanA-4o7dA:
21.16