SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 9 PHE A  72
ASP A  80
GLY A  79
PHE A  78
ASN A  82
 None
LMR  A 401 ( 4.1A)
None
None
None
 1.35A 1i00B-4o7mA:
undetectable		 1i00B-4o7mA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		3 / 3 TRP A 218
GLU A 235
TYR A 299
 None
 1.22A 2a3aA-4o7mA:
undetectable		 2a3aA-4o7mA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		3 / 3 ASN A 216
TYR A 243
SER A 219
 LMR  A 401 (-3.4A)
LMR  A 401 (-4.5A)
None
 0.93A 2gvcE-4o7mA:
undetectable		 2gvcE-4o7mA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 10 VAL A 195
PHE A 187
SER A 159
GLY A 172
ALA A 192
 None
 1.44A 2x2iB-4o7mA:
undetectable		 2x2iB-4o7mA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 9 ALA A  52
VAL A 245
ILE A 271
GLY A 274
ILE A 277
 None
 1.19A 3el4B-4o7mA:
undetectable		 3el4B-4o7mA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 9 PHE A  72
ASP A  80
GLY A  79
PHE A  78
ASN A  82
 None
LMR  A 401 ( 4.1A)
None
None
None
 1.39A 4eb4C-4o7mA:
undetectable		 4eb4C-4o7mA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		4 / 6 ARG A 176
GLY A 213
GLN A 186
MET A 312
 LMR  A 401 (-2.9A)
None
None
None
 0.91A 4g0vB-4o7mA:
undetectable		 4g0vB-4o7mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		4 / 7 LEU A  58
VAL A  59
TYR A 273
GLU A 269
 None
 0.87A 4lb2A-4o7mA:
undetectable		 4lb2A-4o7mA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		4 / 5 THR A  46
PRO A  47
PHE A 199
ASN A 153
 None
None
LMR  A 401 (-3.6A)
None
 1.20A 4mf6A-4o7mA:
undetectable		 4mf6A-4o7mA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 10 LEU A  99
LEU A  84
GLY A 147
VAL A 246
VAL A 145
 None
 1.34A 4yb6A-4o7mA:
4.2
4yb6D-4o7mA:
3.1		 4yb6A-4o7mA:
24.51
4yb6D-4o7mA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		4 / 6 SER A 236
GLU A 235
ARG A 176
GLY A 213
 None
None
LMR  A 401 (-2.9A)
None
 0.77A 5cdnA-4o7mA:
undetectable
5cdnB-4o7mA:
undetectable		 5cdnA-4o7mA:
20.97
5cdnB-4o7mA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 12 VAL A 245
ASP A 242
ASN A 153
PRO A  47
GLY A  49
 None
 1.04A 6gnfA-4o7mA:
undetectable		 6gnfA-4o7mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		5 / 12 VAL A 245
ASP A 242
ASN A 153
PRO A  47
GLY A  49
 None
 1.04A 6gnfC-4o7mA:
undetectable		 6gnfC-4o7mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Shewanella
loihica) 		4 / 7 GLN A  50
GLY A  49
VAL A  41
SER A 219
 None
 1.03A 6hu9S-4o7mA:
undetectable
6hu9q-4o7mA:
undetectable		 6hu9S-4o7mA:
16.29
6hu9q-4o7mA:
19.05