SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 398
VAL A 393
TRP A 392
 None
 0.77A 1kqeA-4o7pA:
undetectable
1kqeE-4o7pA:
undetectable		 1kqeA-4o7pA:
2.06
1kqeE-4o7pA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 398
VAL A 393
TRP A 392
 None
 0.76A 1kqeB-4o7pA:
undetectable
1kqeD-4o7pA:
undetectable		 1kqeB-4o7pA:
2.06
1kqeD-4o7pA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 392
ALA A 398
VAL A 393
 None
 0.78A 1kqeB-4o7pA:
undetectable
1kqeD-4o7pA:
undetectable		 1kqeB-4o7pA:
2.06
1kqeD-4o7pA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 392
ALA A 398
VAL A 393
 None
 0.77A 1kqeA-4o7pA:
undetectable
1kqeE-4o7pA:
undetectable		 1kqeA-4o7pA:
2.06
1kqeE-4o7pA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 398
VAL A 393
TRP A 392
 None
 0.89A 1micA-4o7pA:
undetectable
1micB-4o7pA:
undetectable		 1micA-4o7pA:
3.17
1micB-4o7pA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 227
VAL A 229
TRP A 392
 None
 0.83A 1nt6A-4o7pA:
undetectable		 1nt6A-4o7pA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 227
VAL A 229
TRP A 392
 None
 0.83A 1nt6B-4o7pA:
undetectable		 1nt6B-4o7pA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 408
ILE A 410
ASP A 411
ARG A 413
 None
 1.07A 2v57A-4o7pA:
undetectable		 2v57A-4o7pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 408
ILE A 410
ASP A 411
ARG A 413
 None
 1.06A 2v57C-4o7pA:
undetectable		 2v57C-4o7pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 281
VAL A 292
GLU A 430
 None
 0.83A 2x9gA-4o7pA:
undetectable		 2x9gA-4o7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  65
VAL A 162
ARG A 160
 None
 0.85A 3b0wB-4o7pA:
undetectable		 3b0wB-4o7pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 360
HIS A 324
VAL A 364
VAL A 328
TYR A 404
 None
BTB  A 501 (-4.4A)
None
None
None
 0.95A 3sm2B-4o7pA:
undetectable		 3sm2B-4o7pA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 402
PHE A 368
ASN A 396
ASP A 411
ARG A 413
 None
 1.45A 3wemA-4o7pA:
undetectable		 3wemA-4o7pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 186
LEU A 188
GLU A 125
 None
 0.73A 4l3gF-4o7pA:
2.1		 4l3gF-4o7pA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.90A 4txnA-4o7pA:
undetectable		 4txnA-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.94A 4txnB-4o7pA:
undetectable		 4txnB-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.93A 4txnC-4o7pA:
undetectable		 4txnC-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.93A 4txnD-4o7pA:
undetectable		 4txnD-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 295
LEU A 424
THR A 288
VAL A 292
 None
 1.04A 4udaA-4o7pA:
undetectable		 4udaA-4o7pA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 137
PRO A 136
ILE A 149
ASP A 151
 None
 1.38A 4z4hA-4o7pA:
undetectable		 4z4hA-4o7pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 261
HIS A 262
HIS A 320
LEU A 172
 None
 1.40A 5hrqH-4o7pA:
undetectable
5hrqK-4o7pA:
undetectable
5hrqL-4o7pA:
undetectable		 5hrqH-4o7pA:
5.10
5hrqK-4o7pA:
4.30
5hrqL-4o7pA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4o7p MALTOKINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 341
ASP A 169
LEU A  47
ALA A 207
GLY A 189
 None
 1.19A 5syeB-4o7pA:
undetectable		 5syeB-4o7pA:
21.66