SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 231
THR A 232
PRO A 194
LEU A  52
 None
 0.75A 1hmyA-4o7zA:
undetectable		 1hmyA-4o7zA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A  82
PHE A  27
LEU A  23
LEU A 176
 None
 1.27A 1skxA-4o7zA:
undetectable		 1skxA-4o7zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 169
LEU A 164
TYR A 163
LEU A  52
 None
 0.94A 4qopC-4o7zA:
undetectable		 4qopC-4o7zA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 THR A  37
ALA A  33
THR A  32
ALA A  31
 None
PO4  A 302 (-3.7A)
None
None
 0.91A 4qw0K-4o7zA:
undetectable		 4qw0K-4o7zA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 THR A  37
ALA A  33
THR A  32
ALA A  31
 None
PO4  A 302 (-3.7A)
None
None
 0.91A 4qw0Y-4o7zA:
undetectable		 4qw0Y-4o7zA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 128
ARG A 198
ARG A  93
 None
5GP  A 301 (-3.0A)
5GP  A 301 (-2.9A)
 0.98A 4x5iA-4o7zA:
undetectable		 4x5iA-4o7zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A 191
LYS A  13
ASP A 190
GLU A 177
 None
 1.31A 5a06A-4o7zA:
undetectable		 5a06A-4o7zA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A  92
VAL A 117
ILE A 149
PHE A 178
LEU A 176
 None
 1.30A 5e4dA-4o7zA:
undetectable		 5e4dA-4o7zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 SER A 193
ASN A  49
GLU A 191
VAL A  91
GLU A  89
 None
None
None
5GP  A 301 ( 4.5A)
5GP  A 301 ( 3.9A)
 1.44A 5iqdC-4o7zA:
2.8		 5iqdC-4o7zA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  48
LEU A  52
ASN A  49
LEU A 164
LEU A 208
 None
 1.20A 5mwyA-4o7zA:
undetectable		 5mwyA-4o7zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 153
GLU A  89
LEU A 119
ARG A 103
ASP A 128
 None
5GP  A 301 ( 3.9A)
None
ACT  A 303 (-3.5A)
None
 1.42A 5vlmC-4o7zA:
undetectable		 5vlmC-4o7zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 179
GLY A 184
ASP A 190
ASP A  84
MET A  85
 None
 1.31A 5yn6A-4o7zA:
undetectable		 5yn6A-4o7zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 179
GLY A 184
ASP A 190
ASP A  84
MET A  85
 None
 1.32A 5yniA-4o7zA:
undetectable		 5yniA-4o7zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 179
GLY A 184
ASP A 190
ASP A  84
MET A  85
 None
 1.30A 5ynmA-4o7zA:
undetectable		 5ynmA-4o7zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 ILE A 116
ASN A 157
CYH A 197
 None
 0.88A 6bp4A-4o7zA:
undetectable		 6bp4A-4o7zA:
19.81