SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 12 ILE A 127
ILE A  28
PHE A 145
TYR A  14
PHE A  40
 None
 1.40A 2oa1A-4o87A:
undetectable		 2oa1A-4o87A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 8 TYR A  46
GLN A  21
ILE A  17
ASP A  45
 None
 1.12A 2xytH-4o87A:
undetectable		 2xytH-4o87A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 7 TYR A  46
GLN A  21
ILE A  17
ASP A  45
 None
 1.11A 2xytI-4o87A:
undetectable		 2xytI-4o87A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 8 MET A  15
ALA A  16
GLY A  13
ILE A  12
 None
 0.62A 2zm9A-4o87A:
undetectable		 2zm9A-4o87A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 12 THR A 294
LEU A 290
ILE A  12
VAL A  50
LEU A 124
 None
None
None
None
SO4  A 502 (-3.8A)
 1.38A 3a51B-4o87A:
1.2		 3a51B-4o87A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 12 LYS A 313
SER A 147
ILE A 148
LEU A  20
ILE A  28
 None
 0.96A 3drcA-4o87A:
undetectable		 3drcA-4o87A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 12 ILE A  17
ASP A  18
PHE A  40
ILE A  12
ALA A  11
 None
 1.09A 3jb1A-4o87A:
undetectable		 3jb1A-4o87A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		3 / 3 ASP A  18
ASN A  63
SER A  22
 None
CIT  A 501 (-4.6A)
None
 0.86A 3lslA-4o87A:
undetectable
3lslD-4o87A:
undetectable		 3lslA-4o87A:
22.42
3lslD-4o87A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		3 / 3 SER A  22
ASP A  18
ASN A  63
 None
None
CIT  A 501 (-4.6A)
 0.91A 3lslA-4o87A:
undetectable
3lslD-4o87A:
undetectable		 3lslA-4o87A:
22.42
3lslD-4o87A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 8 ASN A 277
ILE A 186
ASN A 192
TRP A 182
 None
 0.94A 4d39A-4o87A:
undetectable		 4d39A-4o87A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 7 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.82A 4eq4A-4o87A:
undetectable		 4eq4A-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 8 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.78A 4eq4B-4o87A:
undetectable		 4eq4B-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 7 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.82A 4eqlA-4o87A:
undetectable		 4eqlA-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 7 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.80A 4eqlB-4o87A:
undetectable		 4eqlB-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 5 LEU A 164
TRP A  68
ILE A  47
ASN A 123
 None
None
None
SO4  A 513 (-4.6A)
 1.19A 4i00A-4o87A:
undetectable		 4i00A-4o87A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 6 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.76A 4l39A-4o87A:
undetectable		 4l39A-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		4 / 7 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.80A 4l39B-4o87A:
undetectable		 4l39B-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 7 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.15A 5murB-4o87A:
undetectable		 5murB-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 9 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.12A 5mvnB-4o87A:
undetectable		 5mvnB-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 10 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.13A 5mvnD-4o87A:
undetectable		 5mvnD-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4o87 N-TAGGED NUCLEASE
(Millerozyma
acaciae) 		5 / 10 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.07A 5mzrC-4o87A:
undetectable		 5mzrC-4o87A:
14.86