SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 ALA A 405
VAL A 455
TRP A 438
 None
None
FAD  A2001 (-3.5A)
 0.81A 1av2A-4o8aA:
undetectable
1av2B-4o8aA:
undetectable		 1av2A-4o8aA:
3.02
1av2B-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 TRP A 438
ALA A 405
VAL A 455
 FAD  A2001 (-3.5A)
None
None
 0.93A 1av2C-4o8aA:
undetectable
1av2D-4o8aA:
undetectable		 1av2C-4o8aA:
3.02
1av2D-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 5 TYR A 552
LEU A 513
VAL A 402
ASP A 370
 2OP  A2002 (-4.7A)
FAD  A2001 (-4.2A)
FAD  A2001 (-4.4A)
FAD  A2001 ( 3.7A)
 1.30A 1dz6A-4o8aA:
undetectable		 1dz6A-4o8aA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 6 ARG A 555
ALA A 436
TYR A 552
GLU A 559
 2OP  A2002 (-3.6A)
FAD  A2001 ( 3.5A)
2OP  A2002 (-4.7A)
FAD  A2001 (-2.7A)
 1.22A 1oniB-4o8aA:
undetectable
1oniC-4o8aA:
undetectable		 1oniB-4o8aA:
14.08
1oniC-4o8aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 PHE A 484
ALA A 470
ILE A 480
ILE A 414
 None
 0.95A 1oniD-4o8aA:
undetectable
1oniF-4o8aA:
undetectable		 1oniD-4o8aA:
14.08
1oniF-4o8aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 5 TYR A 552
GLU A 559
ARG A 555
ALA A 436
 2OP  A2002 (-4.7A)
FAD  A2001 (-2.7A)
2OP  A2002 (-3.6A)
FAD  A2001 ( 3.5A)
 1.22A 1oniE-4o8aA:
0.2
1oniF-4o8aA:
undetectable		 1oniE-4o8aA:
14.08
1oniF-4o8aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 10 ILE A 311
TYR A 363
GLY A 323
LEU A 269
TYR A 284
 None
 1.42A 1s1uA-4o8aA:
undetectable		 1s1uA-4o8aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 10 ALA A 541
LEU A 269
ILE A 365
ARG A 318
THR A 261
 None
 1.41A 1tdrB-4o8aA:
undetectable		 1tdrB-4o8aA:
13.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 5 LYS A 329
ALA A 436
TYR A 552
ARG A 555
ARG A 556
 2OP  A2002 (-2.7A)
FAD  A2001 ( 3.5A)
2OP  A2002 (-4.7A)
2OP  A2002 (-3.6A)
2OP  A2002 ( 2.8A)
 0.11A 1tj2A-4o8aA:
68.9		 1tj2A-4o8aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 ALA A 405
VAL A 455
TRP A 438
 None
None
FAD  A2001 (-3.5A)
 0.84A 1w5uA-4o8aA:
undetectable
1w5uB-4o8aA:
undetectable		 1w5uA-4o8aA:
3.02
1w5uB-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 TRP A 438
ALA A 405
VAL A 455
 FAD  A2001 (-3.5A)
None
None
 0.82A 1w5uA-4o8aA:
undetectable
1w5uB-4o8aA:
undetectable		 1w5uA-4o8aA:
3.02
1w5uB-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 ASP A 370
GLU A 559
TYR A 466
 FAD  A2001 ( 3.7A)
FAD  A2001 (-2.7A)
None
 0.74A 1wsvA-4o8aA:
undetectable		 1wsvA-4o8aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 ALA A 405
VAL A 455
TRP A 438
 None
None
FAD  A2001 (-3.5A)
 0.98A 2izqA-4o8aA:
undetectable
2izqB-4o8aA:
undetectable		 2izqA-4o8aA:
3.02
2izqB-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 TRP A 438
ALA A 405
VAL A 455
 FAD  A2001 (-3.5A)
None
None
 0.85A 2izqC-4o8aA:
undetectable
2izqD-4o8aA:
undetectable		 2izqC-4o8aA:
3.02
2izqD-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 LYS A 329
SER A 283
ASP A 285
ARG A 431
 2OP  A2002 (-2.7A)
None
None
FAD  A2001 (-4.0A)
 1.50A 2rk8B-4o8aA:
undetectable		 2rk8B-4o8aA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 11 ILE A 265
ALA A 268
THR A 261
ARG A 253
GLU A 547
 None
 1.36A 2v0mD-4o8aA:
undetectable		 2v0mD-4o8aA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 0.98A 2v2gA-4o8aA:
undetectable
2v2gB-4o8aA:
undetectable		 2v2gA-4o8aA:
16.69
2v2gB-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 1.02A 2v2gA-4o8aA:
undetectable
2v2gB-4o8aA:
undetectable		 2v2gA-4o8aA:
16.69
2v2gB-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 1.00A 2v2gC-4o8aA:
undetectable
2v2gD-4o8aA:
undetectable		 2v2gC-4o8aA:
16.69
2v2gD-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 7 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 1.02A 2v2gC-4o8aA:
undetectable
2v2gD-4o8aA:
undetectable		 2v2gC-4o8aA:
16.69
2v2gD-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 8 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 0.97A 2v32C-4o8aA:
undetectable
2v32D-4o8aA:
undetectable		 2v32C-4o8aA:
16.69
2v32D-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 8 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 0.95A 2v41C-4o8aA:
undetectable
2v41D-4o8aA:
undetectable		 2v41C-4o8aA:
16.69
2v41D-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 8 THR A 462
VAL A 464
SER A 465
GLU A 103
 FAD  A2001 (-3.3A)
None
None
None
 1.03A 2v41C-4o8aA:
undetectable
2v41D-4o8aA:
undetectable		 2v41C-4o8aA:
16.69
2v41D-4o8aA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 TRP A 438
ALA A 405
VAL A 455
 FAD  A2001 (-3.5A)
None
None
 0.83A 3l8lC-4o8aA:
undetectable
3l8lD-4o8aA:
undetectable		 3l8lC-4o8aA:
3.02
3l8lD-4o8aA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 9 LEU A 479
GLY A 400
ILE A 399
ILE A 418
ILE A 480
 None
 1.09A 3s56B-4o8aA:
undetectable		 3s56B-4o8aA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 8 LEU A 383
ILE A 369
ASN A 368
GLY A 400
ILE A 399
 None
 1.45A 3wxoA-4o8aA:
undetectable		 3wxoA-4o8aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 5 ILE A 328
LEU A 330
LYS A 329
ASN A 368
 None
None
2OP  A2002 (-2.7A)
None
 1.10A 4g19A-4o8aA:
undetectable		 4g19A-4o8aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		3 / 3 TYR A 416
PHE A 389
ARG A 423
 None
 1.12A 4g19D-4o8aA:
undetectable		 4g19D-4o8aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 10 ALA A  98
ALA A  97
ALA A  94
LEU A 381
GLN A  88
 None
 1.19A 4j6cB-4o8aA:
undetectable		 4j6cB-4o8aA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		5 / 12 ASP A 463
LEU A 131
LEU A 520
ASN A 488
LEU A 492
 FAD  A2001 ( 4.2A)
None
None
FAD  A2001 (-3.9A)
None
 1.05A 5nfjB-4o8aA:
2.1		 5nfjB-4o8aA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 9 ILE A 328
TYR A 363
ILE A 399
LEU A 417
 None
 0.80A 5vkqB-4o8aA:
undetectable
5vkqC-4o8aA:
undetectable		 5vkqB-4o8aA:
17.77
5vkqC-4o8aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4o8a BIFUNCTIONAL PROTEIN
PUTA
(Escherichia
coli) 		4 / 8 ARG A 336
GLU A 289
VAL A 554
GLN A 407
 None
 0.99A 6fbvD-4o8aA:
undetectable		 6fbvD-4o8aA:
21.48