SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASN A 161
LEU A  97
ALA A 100
LEU A 101
 None
 0.58A 1hwiD-4o8cA:
undetectable		 1hwiD-4o8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  56
ASP A  12
ASP A 148
 None
 1.05A 2br4A-4o8cA:
3.6		 2br4A-4o8cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  56
ARG A  48
LYS A 181
 None
 1.47A 3okxA-4o8cA:
undetectable		 3okxA-4o8cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 220
ASP A  12
ASP A 211
GLY A 180
VAL A 179
 None
 1.04A 3oxwA-4o8cA:
undetectable		 3oxwA-4o8cA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		4 / 5 VAL A 115
ILE A 117
VAL A  80
THR A  76
 None
 0.68A 4xdtA-4o8cA:
undetectable		 4xdtA-4o8cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4o8c THERMOSTABLE NPPASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 151
GLY A 119
PHE A  91
THR A 145
VAL A 179
 None
 1.20A 5x6yA-4o8cA:
undetectable		 5x6yA-4o8cA:
15.12