SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 TYR A  92
LEU A  95
SER A 174
GLU A  73
 None
None
None
2Q2  A 403 (-2.8A)
 1.08A 1i7zA-4o8mA:
undetectable		 1i7zA-4o8mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 10 ASP A 144
ARG A 262
VAL A 240
TYR A  92
ILE A 105
 None
 1.36A 1q6iB-4o8mA:
undetectable		 1q6iB-4o8mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 11 ILE A  29
VAL A 145
LEU A  77
ALA A  80
VAL A  76
 None
 1.21A 1rv7A-4o8mA:
undetectable
1rv7B-4o8mA:
undetectable		 1rv7A-4o8mA:
13.99
1rv7B-4o8mA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 THR A  27
ILE A  29
PHE A  62
SER A  56
GLN A 253
 None
 1.47A 1xomB-4o8mA:
undetectable		 1xomB-4o8mA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 PHE A 298
TYR A 109
LEU A 208
ALA A 231
ASP A 206
 None
 1.34A 2iyfB-4o8mA:
undetectable		 2iyfB-4o8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 5 TRP A  48
GLY A 268
GLY A 269
PHE A 239
 None
 1.05A 2qr2A-4o8mA:
undetectable
2qr2B-4o8mA:
undetectable		 2qr2A-4o8mA:
21.61
2qr2B-4o8mA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 9 GLU A  26
VAL A  61
GLU A  28
PHE A 245
GLY A 242
 None
 1.47A 2zq0A-4o8mA:
0.0		 2zq0A-4o8mA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 VAL A 196
SER A  68
ASN A  35
TYR A 147
ASN A 210
 None
None
None
2Q2  A 403 (-4.1A)
2Q2  A 403 (-2.8A)
 1.23A 3d4sA-4o8mA:
undetectable		 3d4sA-4o8mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 4 LYS A 117
SER A 326
LEU A 121
SER A 123
 None
 1.24A 3ik6H-4o8mA:
9.0		 3ik6H-4o8mA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 5 LYS A 117
SER A 326
LEU A 121
SER A 123
 None
 1.25A 3iluH-4o8mA:
9.2		 3iluH-4o8mA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 HIS A 232
THR A 230
VAL A 302
ILE A 181
PRO A 108
 None
 1.19A 3kpbC-4o8mA:
undetectable		 3kpbC-4o8mA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 ASN A 106
PRO A 211
SER A 237
GLY A 148
 None
None
2Q2  A 403 (-2.6A)
None
 0.92A 3lslA-4o8mA:
8.9
3lslD-4o8mA:
8.6		 3lslA-4o8mA:
19.88
3lslD-4o8mA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 ILE A 140
ASP A 134
SER A  90
LEU A  77
ILE A  98
 None
 1.20A 3qfxA-4o8mA:
undetectable		 3qfxA-4o8mA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 ILE A 140
ASP A 134
SER A  90
LEU A  77
ILE A  98
 None
 1.18A 3qfxB-4o8mA:
undetectable		 3qfxB-4o8mA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 11 LEU A  77
THR A  88
VAL A 240
SER A 174
LEU A 102
 None
 1.36A 3tbgA-4o8mA:
undetectable		 3tbgA-4o8mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 THR A 233
LEU A 176
VAL A 302
ILE A 306
VAL A 305
 None
 0.99A 4c9lA-4o8mA:
undetectable		 4c9lA-4o8mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 THR A 233
LEU A 176
VAL A 302
ILE A 306
VAL A 305
 None
 1.00A 4c9lB-4o8mA:
undetectable		 4c9lB-4o8mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 6 ASP A  91
LEU A 176
HIS A 235
THR A 233
 2Q2  A 403 (-4.2A)
None
2Q2  A 403 (-3.9A)
None
 1.28A 4paeA-4o8mA:
undetectable		 4paeA-4o8mA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 GLN A 254
ALA A  80
GLY A 242
THR A 243
ALA A 244
 None
 1.17A 4qvpH-4o8mA:
undetectable
4qvpI-4o8mA:
undetectable		 4qvpH-4o8mA:
21.21
4qvpI-4o8mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 GLN A 254
ALA A  80
GLY A 242
THR A 243
ALA A 244
 None
 1.17A 4qvpV-4o8mA:
undetectable
4qvpW-4o8mA:
undetectable		 4qvpV-4o8mA:
21.21
4qvpW-4o8mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 11 GLN A 254
ALA A  80
GLY A 242
THR A 243
ALA A 244
 None
 1.19A 4qw0H-4o8mA:
undetectable
4qw0I-4o8mA:
undetectable		 4qw0H-4o8mA:
21.21
4qw0I-4o8mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 11 GLN A 254
ALA A  80
GLY A 242
THR A 243
ALA A 244
 None
 1.18A 4qw0V-4o8mA:
undetectable
4qw0W-4o8mA:
undetectable		 4qw0V-4o8mA:
21.21
4qw0W-4o8mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		3 / 3 SER A  68
ALA A  32
VAL A  31
 None
 0.46A 4x1iA-4o8mA:
undetectable		 4x1iA-4o8mA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 6 TRP A 125
ILE A 105
ILE A 138
VAL A 240
 None
 0.91A 4zj8A-4o8mA:
undetectable		 4zj8A-4o8mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 SER A 301
MET A  96
PHE A 310
GLU A 209
GLY A 186
 None
 1.41A 4zjlA-4o8mA:
undetectable		 4zjlA-4o8mA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 GLN A 254
ALA A  80
GLY A 242
THR A 243
ALA A 244
 None
 1.20A 5cz7V-4o8mA:
undetectable
5cz7W-4o8mA:
undetectable		 5cz7V-4o8mA:
21.21
5cz7W-4o8mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		3 / 3 SER A  68
ALA A  32
VAL A  31
 None
 0.49A 5eypA-4o8mA:
undetectable		 5eypA-4o8mA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 LEU A 121
PRO A 238
ILE A 105
LEU A 120
 None
 0.95A 5g48A-4o8mA:
undetectable		 5g48A-4o8mA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 SER A 118
ASP A 144
PRO A 143
SER A 261
 None
 1.09A 5l1fA-4o8mA:
undetectable
5l1fB-4o8mA:
5.3		 5l1fA-4o8mA:
17.60
5l1fB-4o8mA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 4 ARG A 170
SER A 174
ASP A  91
HIS A 235
 2Q2  A 403 (-3.0A)
None
2Q2  A 403 (-4.2A)
2Q2  A 403 (-3.9A)
 1.27A 5zhmA-4o8mA:
undetectable		 5zhmA-4o8mA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 6 LEU A  95
TYR A 147
GLN A  36
GLU A  73
 None
2Q2  A 403 (-4.1A)
None
2Q2  A 403 (-2.8A)
 1.50A 6djzC-4o8mA:
undetectable		 6djzC-4o8mA:
20.35