SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		4 / 5 VAL A 329
LEU A 318
MET A 125
ARG A 363
 None
 1.03A 2oiqA-4o8oA:
undetectable		 2oiqA-4o8oA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		5 / 10 LEU A  64
LEU A 334
VAL A 329
SER A 278
ILE A 264
 None
 0.98A 2w9hA-4o8oA:
undetectable		 2w9hA-4o8oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		5 / 10 PHE A 210
ALA A 139
PHE A 162
LEU A 182
THR A 141
 None
AHR  A 402 ( 3.7A)
None
None
None
 1.20A 3a3yA-4o8oA:
undetectable		 3a3yA-4o8oA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		3 / 3 TYR A 349
ASP A 312
HIS A 315
 None
None
CA  A 401 ( 3.7A)
 0.90A 3e23A-4o8oA:
undetectable		 3e23A-4o8oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		5 / 11 LEU A  64
LEU A 334
VAL A 329
SER A 278
ILE A 264
 None
 0.96A 3frbX-4o8oA:
undetectable		 3frbX-4o8oA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		5 / 9 LEU A  64
LEU A 334
VAL A 329
SER A 278
ILE A 264
 None
 0.96A 3freX-4o8oA:
undetectable		 3freX-4o8oA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		3 / 3 PHE A 143
GLN A 251
PHE A 227
 None
CA  A 401 (-2.9A)
None
 0.74A 3rv5A-4o8oA:
undetectable		 3rv5A-4o8oA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		5 / 12 GLY A 340
GLY A  74
ALA A  75
ALA A  77
ALA A 126
 None
 1.04A 3sudA-4o8oA:
undetectable		 3sudA-4o8oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4o8o ALPHA-L-ARABINOFURAN
OSIDASE
(Streptomyces
thermoviolaceus) 		3 / 3 ARG A 320
PHE A 209
PHE A 143
 None
 0.92A 6nknC-4o8oA:
undetectable
6nknJ-4o8oA:
undetectable		 6nknC-4o8oA:
23.06
6nknJ-4o8oA:
9.09