SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		3 / 3 HIS A 316
ASP A 334
ASN A 348
 None
 0.83A 1wg8B-4o8qA:
undetectable		 1wg8B-4o8qA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		3 / 3 ASP A 321
ASN A 319
THR A 484
 None
 0.56A 2pymB-4o8qA:
undetectable		 2pymB-4o8qA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		5 / 11 THR A 368
MET A 295
ILE A 282
LEU A 284
LEU A 402
 None
 1.30A 3a50C-4o8qA:
undetectable		 3a50C-4o8qA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		5 / 12 GLY A 345
ILE A 301
VAL A 483
VAL A 359
VAL A 361
 None
 0.97A 3ucbB-4o8qA:
undetectable		 3ucbB-4o8qA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		5 / 12 GLY A 290
GLY A 291
ILE A 510
GLN A 398
ILE A 374
 None
 1.13A 4fglA-4o8qA:
undetectable
4fglB-4o8qA:
undetectable		 4fglA-4o8qA:
20.23
4fglB-4o8qA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		4 / 5 LEU A 376
PRO A 375
LEU A 397
ILE A 445
 None
 0.99A 4klrA-4o8qA:
undetectable		 4klrA-4o8qA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4o8q COATOMER SUBUNIT
DELTA
(Bos
taurus) 		4 / 5 VAL A 317
LEU A 362
ILE A 344
LEU A 343
 None
 0.82A 4mghA-4o8qA:
undetectable		 4mghA-4o8qA:
11.34