SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		5 / 12 VAL A  80
ILE A 137
VAL A 140
ILE A 142
LEU A  37
 None
 1.16A 1fm4A-4o8uA:
undetectable		 1fm4A-4o8uA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 4 ILE A 165
LEU A 178
VAL A 184
ILE A 191
 None
 0.94A 1fm6D-4o8uA:
undetectable		 1fm6D-4o8uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 4 GLY A  62
ASP A  59
GLY A  29
THR A  33
 None
 0.90A 1hxbB-4o8uA:
undetectable		 1hxbB-4o8uA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		3 / 3 ARG A  67
GLU A  69
TYR A  58
 None
 0.95A 3k37B-4o8uA:
undetectable		 3k37B-4o8uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 4 GLY A  62
ASP A  59
GLY A  29
THR A  33
 None
 0.86A 3k4vC-4o8uA:
undetectable		 3k4vC-4o8uA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 5 GLY A  17
ILE A  31
VAL A  34
SER A 160
 None
 1.00A 4d33B-4o8uA:
undetectable		 4d33B-4o8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 6 GLY A  17
ILE A  31
VAL A  34
SER A 160
 None
 1.02A 4d39B-4o8uA:
undetectable		 4d39B-4o8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		5 / 12 LEU A 120
LEU A 124
LEU A 127
ALA A 128
ALA A  73
 None
 0.95A 4fn9A-4o8uA:
undetectable		 4fn9A-4o8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 4 GLY A 157
LEU A  21
PHE A  25
ILE A 230
 None
 0.95A 4xv2A-4o8uA:
undetectable		 4xv2A-4o8uA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 7 ARG A 150
VAL A 147
LEU A 203
SER A 195
 None
 1.06A 4zphA-4o8uA:
0.0
4zphB-4o8uA:
undetectable		 4zphA-4o8uA:
22.13
4zphB-4o8uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		5 / 12 LEU A 178
ASP A  22
THR A  24
TYR A 220
ASN A 222
 None
 1.43A 5d0yA-4o8uA:
undetectable		 5d0yA-4o8uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		5 / 12 LEU A 178
ASP A  22
THR A  24
TYR A 220
ASN A 222
 None
 1.44A 5d0yB-4o8uA:
undetectable		 5d0yB-4o8uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		4 / 6 TYR A  58
ASP A  15
ILE A  66
ARG A  63
 None
 1.12A 5igyA-4o8uA:
undetectable		 5igyA-4o8uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4o8u UNCHARACTERIZED
PROTEIN PF2046
(Pyrococcus
furiosus) 		5 / 12 ILE A 233
VAL A 184
TYR A 220
VAL A  20
LEU A 178
 None
 1.03A 6ajiA-4o8uA:
undetectable		 6ajiA-4o8uA:
14.19