SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 8 ASN A 311
LEU A 301
ALA A 202
LEU A 205
 None
 1.00A 1hwiB-4o8vA:
undetectable		 1hwiB-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 8 ASN A 311
LEU A 301
ALA A 202
LEU A 205
 None
 0.98A 1hwiC-4o8vA:
undetectable		 1hwiC-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 7 GLU A 346
PHE A 297
MET A 176
ALA A 174
 None
 1.04A 1linA-4o8vA:
undetectable		 1linA-4o8vA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 5 TRP A 193
PRO A 195
LEU A 187
GLY A 234
 None
 1.39A 1ya4C-4o8vA:
undetectable		 1ya4C-4o8vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 12 PHE A 332
LEU A 327
VAL A 340
LEU A 126
ARG A 116
 None
 1.16A 2bxfA-4o8vA:
undetectable		 2bxfA-4o8vA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		3 / 3 ARG A 182
ASN A 255
THR A 194
 None
 0.83A 2q63A-4o8vA:
undetectable		 2q63A-4o8vA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 8 ARG A 182
PRO A 132
VAL A 185
GLY A 197
 None
 0.98A 2qd3A-4o8vA:
undetectable		 2qd3A-4o8vA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 12 LEU A 349
PHE A 344
ILE A 112
PHE A 168
ASP A 171
 None
 1.26A 3ko0A-4o8vA:
undetectable
3ko0B-4o8vA:
undetectable
3ko0C-4o8vA:
undetectable
3ko0D-4o8vA:
undetectable		 3ko0A-4o8vA:
16.23
3ko0B-4o8vA:
16.23
3ko0C-4o8vA:
16.23
3ko0D-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 11 ASP A 171
LEU A 349
PHE A 344
ILE A 112
PHE A 168
 None
 1.27A 3ko0A-4o8vA:
undetectable
3ko0B-4o8vA:
undetectable
3ko0C-4o8vA:
undetectable
3ko0D-4o8vA:
undetectable		 3ko0A-4o8vA:
16.23
3ko0B-4o8vA:
16.23
3ko0C-4o8vA:
16.23
3ko0D-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 11 ASP A 171
LEU A 349
PHE A 344
ILE A 112
PHE A 168
 None
 1.27A 3ko0C-4o8vA:
undetectable
3ko0D-4o8vA:
undetectable
3ko0E-4o8vA:
undetectable
3ko0F-4o8vA:
undetectable		 3ko0C-4o8vA:
16.23
3ko0D-4o8vA:
16.23
3ko0E-4o8vA:
16.23
3ko0F-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 11 ASP A 171
LEU A 349
PHE A 344
ILE A 112
PHE A 168
 None
 1.29A 3ko0K-4o8vA:
undetectable
3ko0L-4o8vA:
undetectable
3ko0M-4o8vA:
undetectable
3ko0N-4o8vA:
undetectable		 3ko0K-4o8vA:
16.23
3ko0L-4o8vA:
16.23
3ko0M-4o8vA:
16.23
3ko0N-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 11 LEU A 349
PHE A 344
ILE A 112
PHE A 168
ASP A 171
 None
 1.23A 3ko0O-4o8vA:
undetectable
3ko0P-4o8vA:
undetectable
3ko0Q-4o8vA:
undetectable
3ko0R-4o8vA:
undetectable		 3ko0O-4o8vA:
16.23
3ko0P-4o8vA:
16.23
3ko0Q-4o8vA:
16.23
3ko0R-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 10 ALA A 110
ARG A 113
GLY A 114
LEU A 355
ILE A 363
 None
 0.94A 3wdmD-4o8vA:
undetectable		 3wdmD-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 7 MET A 176
VAL A 131
TRP A 193
PHE A 297
 None
 1.33A 4jseA-4o8vA:
0.2
4jseB-4o8vA:
undetectable		 4jseA-4o8vA:
23.15
4jseB-4o8vA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		3 / 3 ASP A 190
VAL A 185
ASN A 292
 None
 0.79A 4lmnA-4o8vA:
undetectable		 4lmnA-4o8vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 12 HIS A 192
THR A 191
SER A  91
GLY A 316
PRO A 345
 None
 1.36A 4uinH-4o8vA:
undetectable
4uinL-4o8vA:
undetectable		 4uinH-4o8vA:
19.43
4uinL-4o8vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 8 GLU A 177
GLY A 197
THR A 189
TYR A 141
 None
 0.84A 5flcB-4o8vA:
undetectable		 5flcB-4o8vA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 8 GLU A 177
GLY A 197
THR A 189
TYR A 141
 None
 0.84A 5flcF-4o8vA:
undetectable		 5flcF-4o8vA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		5 / 12 ASN A 292
TYR A 289
GLU A 343
TYR A 348
GLU A  93
 None
 1.37A 5iqdC-4o8vA:
undetectable		 5iqdC-4o8vA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ
(Pseudomonas
putida) 		4 / 4 ASN A 311
SER A 288
ALA A 313
VAL A 285
 None
 1.37A 5nm5A-4o8vA:
undetectable		 5nm5A-4o8vA:
20.79