SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4o92 GLUTATHIONE
S-TRANSFERASE
(Pichia
kudriavzevii) 		4 / 7 ASP A  56
PHE A  58
PHE A  52
SER A  73
 None
 1.48A 1rqpB-4o92A:
2.5		 1rqpB-4o92A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4o92 GLUTATHIONE
S-TRANSFERASE
(Pichia
kudriavzevii) 		4 / 6 LEU A 157
GLN A 158
LEU A 128
PHE A 170
 None
 1.07A 2einP-4o92A:
3.6
2einW-4o92A:
undetectable		 2einP-4o92A:
22.96
2einW-4o92A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4o92 GLUTATHIONE
S-TRANSFERASE
(Pichia
kudriavzevii) 		4 / 7 ASP A  56
PHE A  58
PHE A  52
SER A  73
 None
 1.49A 2v7uB-4o92A:
2.5		 2v7uB-4o92A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4o92 GLUTATHIONE
S-TRANSFERASE
(Pichia
kudriavzevii) 		5 / 12 LEU A  60
ALA A  51
GLY A  57
ILE A  66
LEU A   6
 None
 1.29A 3gyqA-4o92A:
2.7
3gyqB-4o92A:
undetectable		 3gyqA-4o92A:
22.43
3gyqB-4o92A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4o92 GLUTATHIONE
S-TRANSFERASE
(Pichia
kudriavzevii) 		4 / 8 PHE A  70
SER A  73
PHE A  52
LEU A  60
 None
 0.95A 3i45A-4o92A:
undetectable		 3i45A-4o92A:
20.72