SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 6 ALA A 300
SER A 354
LEU A 301
TRP A 306
 None
 0.93A 1gahA-4o99A:
undetectable		 1gahA-4o99A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 LEU A  38
ALA A  69
ALA A  73
VAL A  43
MET A  53
 None
 1.17A 1kt4A-4o99A:
undetectable		 1kt4A-4o99A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 ILE A 380
GLY A  89
GLY A 355
ILE A 351
ALA A  94
 None
 0.95A 1nv8B-4o99A:
undetectable		 1nv8B-4o99A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 ILE A 380
GLY A  89
GLY A 355
ILE A 351
ALA A  94
 None
 0.92A 1sg9B-4o99A:
undetectable		 1sg9B-4o99A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 4 ASN A 281
ALA A 296
ARG A 299
TYR A 279
 None
None
None
GOL  A 401 (-3.8A)
 1.39A 2ajyH-4o99A:
undetectable		 2ajyH-4o99A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 4 ASN A 281
ALA A 296
ARG A 299
TYR A 279
 None
None
None
GOL  A 401 (-3.8A)
 1.45A 2ak1H-4o99A:
undetectable		 2ak1H-4o99A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 10 ILE A  52
ALA A  94
ILE A  34
PRO A  80
GLU A  50
 None
 1.39A 2dm6A-4o99A:
undetectable
2dm6B-4o99A:
undetectable		 2dm6A-4o99A:
23.47
2dm6B-4o99A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 5 ALA A 353
ALA A  10
ALA A  37
GLN A 115
VAL A 111
 None
 1.41A 2nyrB-4o99A:
undetectable		 2nyrB-4o99A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 ILE A 358
LEU A 359
GLY A  91
ALA A 387
ALA A 376
 None
 0.97A 2oc8A-4o99A:
undetectable		 2oc8A-4o99A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 GLY A  89
GLY A 355
GLY A 113
ILE A 380
VAL A 386
 None
 0.93A 2oxtC-4o99A:
undetectable		 2oxtC-4o99A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 5 GLN A 190
THR A 216
ALA A  13
ARG A  11
 None
 1.40A 2qhfA-4o99A:
undetectable		 2qhfA-4o99A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 GLY A  91
GLY A 114
ILE A  52
CYH A  88
GLU A 116
 None
 1.27A 2vdvE-4o99A:
undetectable		 2vdvE-4o99A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 10 THR A 216
ASN A 251
PRO A 350
ASP A 217
GLY A 253
 None
 1.50A 2z71A-4o99A:
0.0
2z71C-4o99A:
0.0		 2z71A-4o99A:
21.07
2z71C-4o99A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 CYH A 356
LEU A  92
ALA A  94
ALA A 256
ILE A   6
 None
 1.05A 3ut5D-4o99A:
undetectable		 3ut5D-4o99A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		6 / 12 ALA A  69
VAL A  33
GLY A  54
ILE A  84
VAL A 111
ILE A  34
 None
 1.34A 4dqbA-4o99A:
undetectable		 4dqbA-4o99A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		3 / 3 TYR A 279
ARG A 303
SER A 278
 GOL  A 401 (-3.8A)
GOL  A 401 (-4.2A)
GOL  A 401 (-4.7A)
 1.11A 4dr2I-4o99A:
undetectable
4dr2J-4o99A:
undetectable		 4dr2I-4o99A:
15.56
4dr2J-4o99A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 10 ASN A 339
GLU A 318
ASP A 217
GLU A 198
GLY A 355
 None
 1.42A 4evyA-4o99A:
undetectable
4evyB-4o99A:
undetectable		 4evyA-4o99A:
17.88
4evyB-4o99A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 LEU A 359
LEU A 363
ILE A   6
GLY A 374
LEU A 388
 None
 0.98A 4lmnA-4o99A:
undetectable		 4lmnA-4o99A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 5 GLY A 385
ALA A 282
GLY A 292
PRO A 293
 None
 0.96A 4u9uA-4o99A:
undetectable		 4u9uA-4o99A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 9 LEU A 378
PHE A 320
ALA A 344
SER A 248
ALA A 247
 None
 1.38A 4wnuB-4o99A:
undetectable		 4wnuB-4o99A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 9 PRO A  65
GLY A  54
GLU A 116
SER A  61
VAL A  56
 None
 1.38A 4x3mA-4o99A:
undetectable		 4x3mA-4o99A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 5 LYS A 264
LEU A 268
LEU A 270
VAL A   4
 None
 1.10A 5cr1A-4o99A:
undetectable		 5cr1A-4o99A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 6 SER A 248
HIS A 349
PRO A 350
LEU A 250
 None
 1.32A 5dzka-4o99A:
undetectable
5dzko-4o99A:
undetectable		 5dzka-4o99A:
19.31
5dzko-4o99A:
0.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 10 ALA A 319
ALA A 247
VAL A 242
LEU A 148
HIS A 156
 None
 1.44A 5eb5B-4o99A:
undetectable		 5eb5B-4o99A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		5 / 12 GLY A  54
ALA A  70
LEU A  75
ALA A  26
GLY A  30
 None
 0.92A 5jglB-4o99A:
undetectable		 5jglB-4o99A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 6 PHE A 320
THR A 160
ASP A 237
GLY A 240
 None
 1.22A 5mraA-4o99A:
undetectable
5mraB-4o99A:
undetectable		 5mraA-4o99A:
18.97
5mraB-4o99A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 8 LEU A  38
ALA A  69
VAL A  43
MET A  53
 None
 1.02A 5nu7A-4o99A:
undetectable		 5nu7A-4o99A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4o99 ACETYL-COA
ACETYLTRANSFERASE
(Cupriavidus
necator) 		4 / 6 GLN A  55
LEU A  29
ARG A  11
PRO A 350
 None
 1.31A 6brdB-4o99A:
undetectable		 6brdB-4o99A:
12.77