SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ALA A 540
VAL A 536
TRP A 537
 None
 0.89A 1c4dC-4o9rA:
undetectable
1c4dD-4o9rA:
undetectable		 1c4dC-4o9rA:
3.31
1c4dD-4o9rA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A 537
ALA A 540
VAL A 536
 None
 0.75A 1c4dC-4o9rA:
undetectable
1c4dD-4o9rA:
undetectable		 1c4dC-4o9rA:
3.31
1c4dD-4o9rA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 GLU A1018
LEU A1068
LEU A1010
ALA A1029
ALA A1091
 None
 1.33A 2bxcB-4o9rA:
undetectable		 2bxcB-4o9rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1036
ALA A1035
ALA A1040
VAL A1016
ILE A1017
 None
 1.07A 3falA-4o9rA:
undetectable		 3falA-4o9rA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 LEU A 367
VAL A 334
VAL A 411
PHE A 360
LEU A 363
 None
 1.37A 3m8pA-4o9rA:
0.8
3m8pB-4o9rA:
undetectable		 3m8pA-4o9rA:
21.55
3m8pB-4o9rA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A1072
ALA A1091
LEU A1010
ASN A1013
LEU A1014
 None
 0.77A 3o02A-4o9rA:
undetectable
3o02B-4o9rA:
undetectable		 3o02A-4o9rA:
22.63
3o02B-4o9rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 SER A 387
GLU A 518
TYR A 394
ASP A 473
 None
CY8  A1201 (-3.3A)
CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
 1.32A 3zs3A-4o9rA:
undetectable		 3zs3A-4o9rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 LEU A 267
ALA A 338
GLY A 415
VAL A 270
ILE A 266
 None
 0.92A 4dqeA-4o9rA:
undetectable		 4dqeA-4o9rA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4A-4o9rA:
undetectable		 4mm4A-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4B-4o9rA:
undetectable		 4mm4B-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TYR A 322
LEU A 325
HIS A 470
THR A 466
 None
 1.08A 4paeA-4o9rA:
undetectable		 4paeA-4o9rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 283
GLY A 277
ILE A 317
GLY A 388
ILE A 234
 None
 0.95A 4q5mA-4o9rA:
undetectable		 4q5mA-4o9rA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 CY8  A1201 (-3.3A)
None
CY8  A1201 (-3.2A)
None
None
None
 1.04A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
GLN A 477
GLU A 518
ASN A 521
LEU A 522
 CY8  A1201 (-3.3A)
None
CY8  A1201 (-3.2A)
None
CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-3.7A)
CY8  A1201 (-3.3A)
None
None
 0.85A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ARG A 400
GLN A 477
PHE A 484
LEU A 522
 CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-3.7A)
CY8  A1201 (-3.9A)
None
 0.89A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
CY8  A1201 (-3.2A)
None
None
None
 1.13A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		11 / 12 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
CY8  A1201 (-3.2A)
None
CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-4.2A)
CY8  A1201 (-3.7A)
CY8  A1201 ( 4.9A)
CY8  A1201 (-3.3A)
None
None
 0.79A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 LEU A 412
ASN A 521
LEU A 325
 None
 0.39A 6exiD-4o9rA:
undetectable		 6exiD-4o9rA:
11.13