SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 9 VAL B 439
VAL B 372
ILE B 280
ALA B 285
LEU B 443
 None
 1.18A 1eqgA-4o9uB:
undetectable		 1eqgA-4o9uB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 PHE B 190
THR B 164
VAL B 165
ALA B 158
 None
 1.04A 1fo4B-4o9uB:
undetectable		 1fo4B-4o9uB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 PHE B 109
ALA B 118
ILE B  99
GLU B 221
 None
 1.01A 1oniA-4o9uB:
undetectable
1oniB-4o9uB:
undetectable		 1oniA-4o9uB:
16.92
1oniB-4o9uB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 7 ILE B  99
GLU B 221
PHE B 109
ALA B 118
 None
 0.99A 1oniG-4o9uB:
undetectable
1oniI-4o9uB:
undetectable		 1oniG-4o9uB:
16.92
1oniI-4o9uB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 11 GLY B 122
GLU B 221
LEU B 171
ILE B  99
ALA B  96
 None
 1.39A 2a58A-4o9uB:
2.6
2a58E-4o9uB:
2.2		 2a58A-4o9uB:
18.44
2a58E-4o9uB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 11 ILE B  99
ALA B  96
GLY B 122
GLU B 221
LEU B 171
 None
 1.40A 2a58C-4o9uB:
2.4
2a58D-4o9uB:
2.4		 2a58C-4o9uB:
18.44
2a58D-4o9uB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 5 LEU B 397
ASN B 362
VAL B 296
ALA B 329
 None
 1.09A 2cizA-4o9uB:
undetectable		 2cizA-4o9uB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 GLY B 215
GLY B 241
THR B 242
ALA B 239
ALA B 240
 None
 1.05A 2ej3B-4o9uB:
undetectable		 2ej3B-4o9uB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 6 LEU B 397
ASN B 362
VAL B 296
ALA B 329
 None
 1.09A 2j5mA-4o9uB:
undetectable		 2j5mA-4o9uB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 8 ARG B 336
GLY B 339
PRO B 299
GLY B 375
 NAP  B 500 (-2.3A)
None
None
NAP  B 500 (-3.7A)
 0.90A 2y6rB-4o9uB:
3.0		 2y6rB-4o9uB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		6 / 12 ALA B 212
GLY B 238
THR B 235
GLY B 234
THR B 245
PHE B 209
 None
 1.45A 2y7hB-4o9uB:
undetectable		 2y7hB-4o9uB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		6 / 12 ALA B 212
GLY B 238
THR B 235
GLY B 234
THR B 245
PHE B 209
 None
 1.44A 2y7hC-4o9uB:
undetectable		 2y7hC-4o9uB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 4 GLY B 222
VAL B 225
GLY B 113
THR B 112
 None
 0.93A 3ib2A-4o9uB:
undetectable		 3ib2A-4o9uB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 ILE B 124
GLY B 125
GLY B  93
PHE B 209
SER B 208
 None
 0.85A 4fakA-4o9uB:
2.9		 4fakA-4o9uB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		3 / 3 PHE B 328
VAL B 326
GLU B 320
 None
 0.83A 4fvqA-4o9uB:
undetectable		 4fvqA-4o9uB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 11 GLY B 226
ALA B 229
LEU B 230
GLY B 222
ALA B  69
 None
 1.17A 4l6v1-4o9uB:
1.7
4l6v6-4o9uB:
undetectable		 4l6v1-4o9uB:
20.51
4l6v6-4o9uB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 9 ALA B  97
THR B  98
ALA B 100
GLY B  90
GLY B  92
 None
 1.18A 4qwuK-4o9uB:
undetectable
4qwuL-4o9uB:
undetectable		 4qwuK-4o9uB:
19.78
4qwuL-4o9uB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		4 / 8 PHE B 220
ALA B 116
LEU B 120
GLY B 121
 None
 0.99A 4xk8a-4o9uB:
undetectable		 4xk8a-4o9uB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 11 LEU B 432
LEU B 315
LEU B 440
LEU B 289
MET B 288
 None
 1.32A 4zn7B-4o9uB:
undetectable		 4zn7B-4o9uB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 12 ALA B 101
THR B 130
PHE B 184
GLY B  94
THR B 214
 None
 1.36A 5hfjC-4o9uB:
2.5		 5hfjC-4o9uB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 LEU B 196
GLY B 131
GLY B 191
LEU B 133
ALA B 137
 None
 1.05A 5l0zB-4o9uB:
2.3		 5l0zB-4o9uB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Thermus
thermophilus) 		5 / 10 PRO B  82
ALA B 206
GLY B 199
ILE B 198
ALA B 135
 None
 1.08A 5vyhA-4o9uB:
undetectable		 5vyhA-4o9uB:
20.22