SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASP A1011
ARG A1539
ILE A1556
 None
 0.73A 1a4gB-4o9xA:
undetectable		 1a4gB-4o9xA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 GLN A1437
PRO A1812
GLU A1811
ASP A1461
 None
 1.25A 1dtlA-4o9xA:
undetectable		 1dtlA-4o9xA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 TYR A 844
GLN A 820
THR A 840
TRP A 843
 None
 1.40A 1eiiA-4o9xA:
undetectable		 1eiiA-4o9xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 TRP A1981
GLY A1968
ASP A1965
TYR A2175
 None
 1.21A 1kf6M-4o9xA:
undetectable
1kf6N-4o9xA:
undetectable		 1kf6M-4o9xA:
14.72
1kf6N-4o9xA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 ALA A2064
TYR A2086
ILE A1784
GLU A1798
 None
 1.06A 1oniA-4o9xA:
undetectable
1oniB-4o9xA:
undetectable		 1oniA-4o9xA:
5.07
1oniB-4o9xA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ALA A2064
TYR A2086
ILE A1784
GLU A1798
 None
 1.09A 1oniB-4o9xA:
undetectable
1oniC-4o9xA:
undetectable		 1oniB-4o9xA:
5.07
1oniC-4o9xA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 TYR A2086
ILE A1784
GLU A1798
ALA A2064
 None
 1.06A 1oniG-4o9xA:
undetectable
1oniI-4o9xA:
undetectable		 1oniG-4o9xA:
5.07
1oniI-4o9xA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 11 LEU A 537
TYR A 530
GLY A 619
PRO A 522
LEU A 548
 None
 1.18A 1p91A-4o9xA:
undetectable		 1p91A-4o9xA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 CYH A 319
ARG A 337
CYH A 246
 None
 1.09A 1p9gA-4o9xA:
undetectable		 1p9gA-4o9xA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 TYR A 817
GLY A 803
TYR A 859
LEU A 855
TYR A 844
 None
 1.45A 1pj7A-4o9xA:
undetectable		 1pj7A-4o9xA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ASN A1946
ARG A1947
ASP A1572
GLY A2171
ARG A2151
 None
 1.26A 1q8jA-4o9xA:
undetectable		 1q8jA-4o9xA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ASP A1498
TYR A1522
ASP A1839
ASN A1843
 None
 1.15A 1rjdA-4o9xA:
undetectable		 1rjdA-4o9xA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ASP A1498
TYR A1522
ASP A1839
ASN A1843
 None
 1.13A 1rjdB-4o9xA:
undetectable		 1rjdB-4o9xA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ASP A1498
TYR A1522
ASP A1839
ASN A1843
 None
 1.15A 1rjdC-4o9xA:
undetectable		 1rjdC-4o9xA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 VAL A1949
THR A1940
GLU A1955
LEU A1953
 None
 1.12A 1s8fB-4o9xA:
undetectable		 1s8fB-4o9xA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 PHE A1964
ASN A1971
ASN A1943
GLN A1959
 None
 1.15A 1t9uA-4o9xA:
undetectable		 1t9uA-4o9xA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASP A2089
TYR A2088
GLU A1798
 None
 0.81A 1vm1A-4o9xA:
undetectable		 1vm1A-4o9xA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASP A 999
GLU A1502
ARG A1545
 None
 0.78A 1wopA-4o9xA:
undetectable		 1wopA-4o9xA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 MET A 418
VAL A 420
LEU A 421
PHE A 424
 None
 1.10A 1x8vA-4o9xA:
undetectable		 1x8vA-4o9xA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 9 GLY A1689
ALA A1688
LEU A1709
TRP A2005
LEU A2016
 None
 1.05A 1y7iA-4o9xA:
undetectable		 1y7iA-4o9xA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 ALA A1958
SER A1942
ASP A1956
ASP A1961
 None
 0.85A 1yc5A-4o9xA:
undetectable		 1yc5A-4o9xA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 9 ASN A1717
ILE A1659
GLU A1649
ALA A1648
THR A1656
 None
 1.19A 2dtjA-4o9xA:
undetectable
2dtjB-4o9xA:
undetectable		 2dtjA-4o9xA:
6.43
2dtjB-4o9xA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLY A 156
PRO A 180
LYS A 181
THR A 182
 None
 1.03A 2m2oB-4o9xA:
undetectable		 2m2oB-4o9xA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 TRP A1214
PHE A 292
ALA A 350
LEU A 351
 None
 1.01A 2o01A-4o9xA:
undetectable		 2o01A-4o9xA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ASP A1965
GLY A1967
GLY A1968
GLN A2154
GLY A1985
 None
 0.91A 2pkkA-4o9xA:
undetectable		 2pkkA-4o9xA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ASP A1965
GLY A1967
GLY A1968
GLN A2154
GLY A1985
 None
 0.91A 2pkmA-4o9xA:
undetectable		 2pkmA-4o9xA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 LEU A 580
PRO A 581
LEU A 540
 None
 0.56A 2po7B-4o9xA:
undetectable		 2po7B-4o9xA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 LEU A 899
ARG A 927
PRO A 886
SER A 891
 None
 1.14A 2qd2A-4o9xA:
undetectable		 2qd2A-4o9xA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ARG A1385
PRO A1354
SER A1292
MET A 740
 None
 1.35A 2qd3B-4o9xA:
undetectable		 2qd3B-4o9xA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ALA A 602
LEU A 558
ILE A 551
LEU A 590
PRO A 641
 None
 1.21A 2qk8A-4o9xA:
undetectable		 2qk8A-4o9xA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 GLN A1388
PHE A1379
TRP A1444
GLY A1405
 None
 1.31A 2qmzA-4o9xA:
undetectable
2qmzB-4o9xA:
undetectable		 2qmzA-4o9xA:
7.30
2qmzB-4o9xA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 9 ALA A 801
ALA A 804
GLY A 814
GLY A 816
ILE A 851
 None
 1.29A 2v7bB-4o9xA:
undetectable		 2v7bB-4o9xA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 PRO A1467
GLY A 910
TYR A 921
 None
 0.69A 2vouA-4o9xA:
undetectable		 2vouA-4o9xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 PRO A1467
GLY A 910
TYR A 921
 None
 0.57A 2vouB-4o9xA:
undetectable		 2vouB-4o9xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 PRO A1467
GLY A 910
TYR A 921
 None
 0.58A 2vouC-4o9xA:
undetectable		 2vouC-4o9xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ARG A1149
PHE A1048
LEU A1071
ASP A1074
 None
 1.14A 2wm3A-4o9xA:
undetectable		 2wm3A-4o9xA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 TYR A2114
TYR A1913
GLN A1890
ILE A1939
 None
 1.07A 2xz5B-4o9xA:
undetectable
2xz5E-4o9xA:
undetectable		 2xz5B-4o9xA:
7.18
2xz5E-4o9xA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 THR A1937
GLN A1890
TYR A2114
TYR A1913
 None
 1.42A 2xz5A-4o9xA:
undetectable
2xz5C-4o9xA:
undetectable		 2xz5A-4o9xA:
7.18
2xz5C-4o9xA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 GLN A1890
ILE A1939
TYR A2114
TYR A1913
 None
 1.08A 2xz5D-4o9xA:
undetectable
2xz5E-4o9xA:
undetectable		 2xz5D-4o9xA:
7.18
2xz5E-4o9xA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 9 GLU A 784
HIS A 743
GLU A 786
PHE A1383
GLY A1384
 None
 1.40A 2zq0A-4o9xA:
undetectable		 2zq0A-4o9xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ALA A 485
LEU A 545
SER A 546
THR A 501
 None
 0.99A 3d2tB-4o9xA:
undetectable		 3d2tB-4o9xA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLY A2093
TYR A2111
GLY A2137
ASN A2090
 None
 1.04A 3e9rA-4o9xA:
undetectable		 3e9rA-4o9xA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLY A2093
TYR A2111
GLY A2137
ASN A2090
 None
 1.00A 3e9rC-4o9xA:
undetectable		 3e9rC-4o9xA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 LEU A2099
SER A2107
GLN A2096
THR A1806
TYR A2086
 None
 1.38A 3fsuA-4o9xA:
undetectable		 3fsuA-4o9xA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLY A 598
SER A 672
LEU A 629
VAL A 605
HIS A 254
 None
 1.24A 3g9eA-4o9xA:
undetectable		 3g9eA-4o9xA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 9 ARG A1385
PRO A1354
SER A1292
GLY A1382
MET A 740
 None
 1.35A 3hcnB-4o9xA:
undetectable		 3hcnB-4o9xA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 ILE A 500
GLN A 482
VAL A 488
PHE A 520
 None
 1.12A 3ieoA-4o9xA:
undetectable		 3ieoA-4o9xA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLY A 387
LEU A1237
ILE A 368
ARG A 384
GLN A 341
 None
 1.13A 3ijdB-4o9xA:
undetectable		 3ijdB-4o9xA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 PRO A 122
PHE A 331
ALA A 219
 None
 0.72A 3itaD-4o9xA:
undetectable		 3itaD-4o9xA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 SER A 652
ASP A 656
ASP A 322
 None
 0.83A 3iv6A-4o9xA:
undetectable		 3iv6A-4o9xA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 VAL A1492
PHE A1490
VAL A1528
PRO A1526
PHE A1543
 None
 1.37A 3nbrA-4o9xA:
undetectable		 3nbrA-4o9xA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLU A2108
THR A1905
ALA A2121
ALA A1898
 None
 1.25A 3ns1C-4o9xA:
undetectable		 3ns1C-4o9xA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 LEU A1182
GLU A1110
ALA A1158
GLY A1139
ASP A1615
 None
 1.44A 3ou6D-4o9xA:
undetectable		 3ou6D-4o9xA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 THR A 218
SER A 210
ARG A 208
 None
 0.80A 3phnA-4o9xA:
undetectable		 3phnA-4o9xA:
3.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLY A 598
LEU A 597
ALA A 377
ASP A 322
SER A 672
 None
 1.13A 3tbgB-4o9xA:
undetectable		 3tbgB-4o9xA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLY A 598
LEU A 597
ALA A 377
ASP A 322
SER A 672
 None
 1.13A 3tbgD-4o9xA:
undetectable		 3tbgD-4o9xA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 HIS A 253
HIS A 254
ILE A 627
 None
 0.86A 3u52A-4o9xA:
undetectable
3u52C-4o9xA:
undetectable		 3u52A-4o9xA:
13.01
3u52C-4o9xA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 TYR A1522
THR A1869
TYR A1874
TYR A1870
 None
 1.29A 3wipF-4o9xA:
undetectable
3wipG-4o9xA:
undetectable		 3wipF-4o9xA:
6.98
3wipG-4o9xA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 TYR A1522
THR A1869
TYR A1874
TYR A1870
 None
 1.31A 3wipF-4o9xA:
undetectable
3wipJ-4o9xA:
undetectable		 3wipF-4o9xA:
6.98
3wipJ-4o9xA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 11 PRO A 513
SER A 510
THR A 518
TYR A 508
ARG A 557
 None
 1.41A 3zqeA-4o9xA:
undetectable
3zqeB-4o9xA:
undetectable		 3zqeA-4o9xA:
9.35
3zqeB-4o9xA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 11 GLY A 705
ALA A  97
GLY A  98
ASN A  94
MET A  70
 None
 0.96A 4a6nA-4o9xA:
undetectable		 4a6nA-4o9xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ASP A 297
SER A 302
ASN A 303
GLY A 315
 None
 1.01A 4af0A-4o9xA:
undetectable		 4af0A-4o9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ALA A 485
LEU A 545
SER A 546
THR A 501
 None
 1.05A 4d7bB-4o9xA:
undetectable		 4d7bB-4o9xA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 SER A 325
TYR A 327
GLY A 673
PRO A 654
 None
 1.46A 4e3aA-4o9xA:
undetectable		 4e3aA-4o9xA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ARG A 813
TRP A 805
GLY A 807
 None
 0.81A 4e7cA-4o9xA:
undetectable		 4e7cA-4o9xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 SER A  80
GLY A  82
THR A1218
VAL A1196
 None
 1.04A 4eohA-4o9xA:
undetectable		 4eohA-4o9xA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ARG A 892
ASN A 853
ASP A 852
ILE A 851
 None
 1.07A 4k0bA-4o9xA:
undetectable		 4k0bA-4o9xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 ARG A1385
PRO A1354
SER A1292
MET A 740
 None
 1.23A 4klrA-4o9xA:
undetectable		 4klrA-4o9xA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 PHE A1245
TYR A1256
THR A1362
THR A1699
 None
 1.17A 4l4eA-4o9xA:
undetectable		 4l4eA-4o9xA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ARG A 892
ASN A 853
ASP A 852
ILE A 851
 None
 0.95A 4l7iA-4o9xA:
undetectable		 4l7iA-4o9xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 ASN A  99
GLY A 103
ASP A  68
ASP A 107
 None
 1.29A 4n49A-4o9xA:
undetectable		 4n49A-4o9xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ALA A1966
GLY A1967
GLY A1968
ASP A1606
ASN A1971
 None
 0.96A 4obwB-4o9xA:
undetectable		 4obwB-4o9xA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.08A 4oltA-4o9xA:
undetectable		 4oltA-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 1.02A 4oltA-4o9xA:
undetectable		 4oltA-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.02A 4oltB-4o9xA:
undetectable		 4oltB-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 0.98A 4oltB-4o9xA:
undetectable		 4oltB-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 THR A1736
HIS A1675
LEU A1677
SER A1739
 None
 0.93A 4pfjA-4o9xA:
undetectable		 4pfjA-4o9xA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 ALA A 485
LEU A 545
SER A 546
THR A 501
 None
 0.98A 4pwjB-4o9xA:
undetectable		 4pwjB-4o9xA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ARG A2007
GLN A1988
GLU A1715
 None
 0.76A 4tvtA-4o9xA:
undetectable		 4tvtA-4o9xA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 LEU A 131
VAL A 137
GLU A 136
ARG A 167
 None
 1.29A 4ww7A-4o9xA:
undetectable		 4ww7A-4o9xA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ALA A1626
GLY A1608
ALA A1607
GLY A1968
 None
 0.65A 4zjzA-4o9xA:
undetectable		 4zjzA-4o9xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 GLY A2116
TYR A2148
TYR A2135
GLY A2137
 None
 1.07A 5ayfA-4o9xA:
undetectable		 5ayfA-4o9xA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 TYR A1365
GLY A1700
SER A1697
LEU A1698
 None
 1.29A 5bphC-4o9xA:
undetectable		 5bphC-4o9xA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 TYR A1365
GLY A1700
SER A1697
LEU A1698
 None
 1.24A 5bphD-4o9xA:
undetectable		 5bphD-4o9xA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ALA A 310
ASN A 359
HIS A 388
THR A 307
 None
 1.27A 5db5A-4o9xA:
undetectable
5db5B-4o9xA:
undetectable		 5db5A-4o9xA:
10.79
5db5B-4o9xA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASP A 973
ARG A 165
ARG A1035
 None
 0.84A 5eajB-4o9xA:
undetectable		 5eajB-4o9xA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLU A2098
GLU A2109
ILE A2133
TYR A2034
ARG A2041
 None
 1.24A 5edlA-4o9xA:
undetectable		 5edlA-4o9xA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLY A 673
GLY A 675
ILE A 627
ILE A 376
LEU A 646
 None
 0.92A 5fa8A-4o9xA:
undetectable		 5fa8A-4o9xA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 HIS A1159
GLN A1181
ILE A1616
TYR A1140
 None
 1.22A 5fuqA-4o9xA:
undetectable
5fuqB-4o9xA:
undetectable		 5fuqA-4o9xA:
7.74
5fuqB-4o9xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 VAL A 395
GLU A 389
GLY A 387
LEU A1237
 None
 1.25A 5g5gC-4o9xA:
undetectable		 5g5gC-4o9xA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASP A 961
SER A1009
TYR A1010
 None
 0.90A 5glmA-4o9xA:
undetectable		 5glmA-4o9xA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 VAL A 433
ALA A 699
ILE A 710
GLN A 695
SER A 712
 None
 1.28A 5hgcA-4o9xA:
undetectable		 5hgcA-4o9xA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 GLU A2060
GLU A1798
THR A1806
LEU A1817
 None
 1.24A 5hm8G-4o9xA:
undetectable		 5hm8G-4o9xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.05A 5hwaA-4o9xA:
undetectable		 5hwaA-4o9xA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 1.01A 5hwaA-4o9xA:
undetectable		 5hwaA-4o9xA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 GLY A 502
THR A 518
GLY A 621
LEU A 558
 None
 0.78A 5jlcA-4o9xA:
undetectable		 5jlcA-4o9xA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 TYR A 955
SER A 960
TRP A 860
 None
 0.78A 5n8jB-4o9xA:
undetectable		 5n8jB-4o9xA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 TYR A 955
SER A 960
TRP A 860
 None
 0.77A 5n8jA-4o9xA:
undetectable		 5n8jA-4o9xA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 TYR A 955
SER A 960
TRP A 860
 None
 0.82A 5n8jD-4o9xA:
undetectable		 5n8jD-4o9xA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 GLN A 287
THR A 244
SER A 316
GLY A 315
THR A 314
 None
 1.38A 5oj0A-4o9xA:
undetectable		 5oj0A-4o9xA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ASP A1498
THR A1499
THR A1525
TYR A1874
 None
 1.21A 5ov9B-4o9xA:
undetectable		 5ov9B-4o9xA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ASP A1498
THR A1499
TYR A1522
THR A1525
 None
 1.01A 5ov9B-4o9xA:
undetectable		 5ov9B-4o9xA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 GLN A 341
ASP A 297
HIS A 264
TYR A 268
 None
 1.39A 5ov9B-4o9xA:
undetectable		 5ov9B-4o9xA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 LEU A 545
TYR A 559
PRO A 583
LEU A 548
 None
 1.04A 5t7bA-4o9xA:
undetectable		 5t7bA-4o9xA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 ALA A2064
VAL A2066
ASP A2089
TYR A2088
 None
 1.20A 5umd2-4o9xA:
undetectable
5umdF-4o9xA:
undetectable		 5umd2-4o9xA:
3.32
5umdF-4o9xA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 ARG A1911
PRO A2113
GLY A2115
TYR A2112
 None
 1.05A 5x80A-4o9xA:
undetectable
5x80B-4o9xA:
undetectable		 5x80A-4o9xA:
6.19
5x80B-4o9xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 PRO A2113
GLY A2115
TYR A2112
ARG A1911
 None
 1.06A 5x80C-4o9xA:
undetectable
5x80D-4o9xA:
undetectable		 5x80C-4o9xA:
6.19
5x80D-4o9xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 ILE A1241
CYH A1285
GLN A1284
ILE A1373
LEU A1276
 None
HG  A2205 (-3.5A)
None
None
None
 1.19A 5y2tB-4o9xA:
undetectable		 5y2tB-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 PHE A1481
THR A1484
GLU A1496
ASN A1843
 None
 1.32A 5ybbA-4o9xA:
undetectable		 5ybbA-4o9xA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ILE A  43
THR A  44
THR A1208
SER A  47
 None
 1.13A 6c06C-4o9xA:
undetectable		 6c06C-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 HIS A1926
TYR A1935
TYR A2112
GLN A1890
 None
 1.39A 6d8pA-4o9xA:
undetectable		 6d8pA-4o9xA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 5 TYR A 327
GLN A 601
GLY A 675
ILE A 627
 None
 1.24A 6debB-4o9xA:
undetectable		 6debB-4o9xA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLN A 902
VAL A 947
GLU A 949
ALA A 867
 None
 1.20A 6djzB-4o9xA:
undetectable		 6djzB-4o9xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 6 GLY A 673
ASN A 674
SER A 325
ARG A 334
 None
 1.14A 6dwdA-4o9xA:
undetectable
6dwdC-4o9xA:
undetectable		 6dwdA-4o9xA:
14.19
6dwdC-4o9xA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 LEU A1834
ILE A1820
GLY A1819
ILE A1818
VAL A2183
 None
 0.95A 6emuC-4o9xA:
undetectable		 6emuC-4o9xA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 LEU A1006
ASN A 916
LEU A1485
 None
 0.71A 6exiD-4o9xA:
undetectable		 6exiD-4o9xA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 GLN A 820
THR A 821
THR A 835
LEU A 908
 None
 1.38A 6f3mA-4o9xA:
undetectable		 6f3mA-4o9xA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 4 GLN A 820
THR A 821
THR A 835
LEU A 908
 None
 1.38A 6f3mC-4o9xA:
undetectable		 6f3mC-4o9xA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 8 ASP A1686
ARG A2013
VAL A1702
GLN A2065
 None
 1.08A 6fbvD-4o9xA:
undetectable		 6fbvD-4o9xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 VAL A2178
ARG A1911
GLN A1890
PRO A2155
GLY A2158
 None
 1.25A 6gnfA-4o9xA:
undetectable		 6gnfA-4o9xA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		5 / 12 VAL A2178
ARG A1911
GLN A1890
PRO A2155
GLY A2158
 None
 1.24A 6gnfC-4o9xA:
undetectable		 6gnfC-4o9xA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		4 / 7 ILE A1616
GLN A1181
HIS A1159
TRP A1156
 None
 1.13A 6j20A-4o9xA:
undetectable		 6j20A-4o9xA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 ASN A1943
PRO A1957
GLN A1959
 None
 0.95A 6jogA-4o9xA:
undetectable		 6jogA-4o9xA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4o9x TCDB2, TCCC3
(Photorhabdus
luminescens) 		3 / 3 THR A 840
GLU A 858
ASN A 842
 None
 0.85A 6nj9K-4o9xA:
undetectable		 6nj9K-4o9xA:
10.93