SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 12 GLY A 447
LEU A 450
TYR A 451
VAL A 388
PHE A 435
 None
 1.25A 1a27A-4oahA:
undetectable		 1a27A-4oahA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 VAL A 262
VAL A 252
TRP A 337
 None
 0.85A 1av2C-4oahA:
undetectable
1av2D-4oahA:
undetectable		 1av2C-4oahA:
3.75
1av2D-4oahA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 6 ASN A 433
HIS A 391
GLY A 422
TYR A 418
 None
 1.14A 1c8lA-4oahA:
undetectable		 1c8lA-4oahA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 TRP A 248
VAL A 209
PRO A 180
 None
 0.88A 1rg1A-4oahA:
undetectable		 1rg1A-4oahA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 TRP A 248
VAL A 209
PRO A 180
 None
 0.88A 1rh0A-4oahA:
undetectable		 1rh0A-4oahA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 VAL A 262
VAL A 252
TRP A 337
 None
 0.83A 1w5uC-4oahA:
undetectable
1w5uD-4oahA:
undetectable		 1w5uC-4oahA:
3.75
1w5uD-4oahA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 7 ILE A 274
PHE A 312
LEU A 296
ILE A 164
 None
 0.67A 1yc2E-4oahA:
undetectable		 1yc2E-4oahA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 6 THR A 346
SER A 189
ASP A 192
VAL A 196
 None
SO4  A 501 (-2.5A)
None
None
 1.25A 2hdnI-4oahA:
undetectable
2hdnJ-4oahA:
undetectable
2hdnL-4oahA:
undetectable		 2hdnI-4oahA:
8.42
2hdnJ-4oahA:
23.20
2hdnL-4oahA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 6 VAL A 196
THR A 346
SER A 189
ASP A 192
 None
None
SO4  A 501 (-2.5A)
None
 1.29A 2hdnJ-4oahA:
undetectable
2hdnK-4oahA:
undetectable
2hdnL-4oahA:
undetectable		 2hdnJ-4oahA:
23.20
2hdnK-4oahA:
8.42
2hdnL-4oahA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 5 LEU A 168
LEU A 298
ILE A 287
ALA A 161
 None
 0.70A 2i2zA-4oahA:
undetectable		 2i2zA-4oahA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 VAL A 252
TRP A 337
VAL A 262
 None
 0.85A 2izqA-4oahA:
undetectable
2izqB-4oahA:
undetectable		 2izqA-4oahA:
3.75
2izqB-4oahA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 12 LEU A 412
ALA A 411
TRP A 399
LEU A 139
LEU A 362
 None
 1.34A 2oaxD-4oahA:
undetectable		 2oaxD-4oahA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 12 LEU A 412
ALA A 411
TRP A 399
LEU A 139
LEU A 362
 None
 1.22A 2oaxF-4oahA:
undetectable		 2oaxF-4oahA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 VAL A 262
VAL A 252
TRP A 337
 None
 0.82A 3l8lA-4oahA:
undetectable
3l8lB-4oahA:
undetectable		 3l8lA-4oahA:
3.75
3l8lB-4oahA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		3 / 3 VAL A 262
VAL A 252
TRP A 337
 None
 0.77A 3l8lC-4oahA:
undetectable
3l8lD-4oahA:
undetectable		 3l8lC-4oahA:
3.75
3l8lD-4oahA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 12 ARG A 326
GLU A 437
PHE A 230
VAL A 227
VAL A 432
 None
 1.11A 3qwuA-4oahA:
undetectable		 3qwuA-4oahA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 ARG A 326
GLU A 437
PHE A 230
VAL A 227
VAL A 432
 None
 1.16A 3qwuB-4oahA:
undetectable		 3qwuB-4oahA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 LEU A 377
LEU A 380
LEU A 450
ALA A 411
LEU A 415
 None
 1.03A 4wg0B-4oahA:
undetectable
4wg0C-4oahA:
undetectable
4wg0D-4oahA:
undetectable		 4wg0B-4oahA:
6.74
4wg0C-4oahA:
6.74
4wg0D-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 LEU A 377
LEU A 380
LEU A 450
ALA A 411
LEU A 415
 None
 1.02A 4wg0D-4oahA:
undetectable
4wg0E-4oahA:
undetectable
4wg0F-4oahA:
undetectable		 4wg0D-4oahA:
6.74
4wg0E-4oahA:
6.74
4wg0F-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 LEU A 377
LEU A 380
LEU A 450
ALA A 411
LEU A 415
 None
 1.03A 4wg0F-4oahA:
undetectable
4wg0G-4oahA:
undetectable
4wg0H-4oahA:
undetectable		 4wg0F-4oahA:
6.74
4wg0G-4oahA:
6.74
4wg0H-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 LEU A 377
LEU A 380
LEU A 450
ALA A 411
LEU A 415
 None
 1.04A 4wg0H-4oahA:
undetectable
4wg0I-4oahA:
undetectable
4wg0J-4oahA:
undetectable		 4wg0H-4oahA:
6.74
4wg0I-4oahA:
6.74
4wg0J-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 ALA A 411
LEU A 415
LEU A 450
LEU A 377
LEU A 380
 None
 1.05A 4wg0G-4oahA:
undetectable
4wg0H-4oahA:
undetectable
4wg0I-4oahA:
undetectable		 4wg0G-4oahA:
6.74
4wg0H-4oahA:
6.74
4wg0I-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 LEU A 377
LEU A 380
LEU A 450
ALA A 411
LEU A 415
 None
 1.04A 4wg0J-4oahA:
undetectable
4wg0K-4oahA:
undetectable
4wg0L-4oahA:
undetectable		 4wg0J-4oahA:
6.74
4wg0K-4oahA:
6.74
4wg0L-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 ALA A 411
LEU A 415
LEU A 450
LEU A 377
LEU A 380
 None
 1.00A 4wg0I-4oahA:
undetectable
4wg0J-4oahA:
undetectable
4wg0K-4oahA:
undetectable		 4wg0I-4oahA:
6.74
4wg0J-4oahA:
6.74
4wg0K-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		5 / 11 ALA A 411
LEU A 415
LEU A 450
LEU A 377
LEU A 380
 None
 0.99A 4wg0K-4oahA:
undetectable
4wg0L-4oahA:
undetectable
4wg0M-4oahA:
undetectable		 4wg0K-4oahA:
6.74
4wg0L-4oahA:
6.74
4wg0M-4oahA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51
(Mus
musculus) 		4 / 8 LEU A 204
VAL A 300
LEU A 298
ILE A 287
 None
 0.78A 6cb4A-4oahA:
undetectable		 6cb4A-4oahA:
22.46