SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 11 ILE A 235
SER A 175
GLY A 177
ASN A 182
GLY A 146
 FAD  A 601 (-4.5A)
FAD  A 601 (-2.7A)
FAD  A 601 (-3.5A)
FAD  A 601 (-4.2A)
FAD  A 601 ( 4.2A)
 1.37A 1ho5A-4oalA:
undetectable		 1ho5A-4oalA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 12 HIS A 500
HIS A 491
SER A 101
GLN A 526
PHE A 509
 None
None
FAD  A 601 (-2.7A)
FAD  A 601 (-3.9A)
None
 1.42A 1qu3A-4oalA:
undetectable		 1qu3A-4oalA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 7 TYR A 425
GLU A 285
LEU A 452
TYR A 487
 None
None
245  A 602 (-4.1A)
FAD  A 601 ( 4.6A)
 1.03A 1tuvA-4oalA:
2.9		 1tuvA-4oalA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 4 ASP A 152
LEU A 172
LEU A 154
LEU A 149
 None
 1.38A 1u18A-4oalA:
undetectable		 1u18A-4oalA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		3 / 3 ASP A 282
PHE A 190
ARG A 280
 None
 0.86A 2a3aA-4oalA:
undetectable		 2a3aA-4oalA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 6 TRP A 156
LEU A 154
LEU A 158
PRO A 131
 None
 1.12A 2dqyC-4oalA:
undetectable		 2dqyC-4oalA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 8 PHE A 233
LEU A 512
PHE A 509
GLY A 229
 None
 0.91A 2vdbA-4oalA:
undetectable		 2vdbA-4oalA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		3 / 3 TYR A 200
GLU A 244
ASP A 331
 None
 0.88A 3bxoB-4oalA:
undetectable		 3bxoB-4oalA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 12 PRO A 194
GLY A 177
GLY A 225
LEU A 202
ILE A 236
 None
FAD  A 601 (-3.5A)
None
None
FAD  A 601 (-3.9A)
 0.96A 3ku1A-4oalA:
undetectable		 3ku1A-4oalA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 12 PRO A 194
GLY A 177
GLY A 225
LEU A 202
ILE A 236
 None
FAD  A 601 (-3.5A)
None
None
FAD  A 601 (-3.9A)
 0.97A 3ku1G-4oalA:
undetectable		 3ku1G-4oalA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		3 / 3 GLU A 210
GLU A 218
ASN A 219
 None
 0.90A 3lp9B-4oalA:
undetectable
3lp9D-4oalA:
undetectable		 3lp9B-4oalA:
17.55
3lp9D-4oalA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 8 LEU A 367
GLN A 188
TYR A 363
PHE A 366
 None
 1.12A 3po7A-4oalA:
undetectable		 3po7A-4oalA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 8 ASP A  49
HIS A  70
ASP A  46
GLU A 384
 None
 1.10A 3sg9B-4oalA:
undetectable		 3sg9B-4oalA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 12 GLY A  97
GLY A 178
THR A 179
VAL A 113
GLY A  99
 FAD  A 601 (-3.6A)
FAD  A 601 (-3.7A)
FAD  A 601 (-4.6A)
None
FAD  A 601 (-3.6A)
 1.09A 3sglA-4oalA:
undetectable		 3sglA-4oalA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 5 ILE A 185
PRO A 194
SER A 181
GLY A 184
 FAD  A 601 (-4.3A)
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.3A)
 1.13A 3tkdB-4oalA:
undetectable		 3tkdB-4oalA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 5 ILE A 185
PRO A 194
SER A 181
GLY A 184
 FAD  A 601 (-4.3A)
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.3A)
 1.15A 3tkdA-4oalA:
undetectable		 3tkdA-4oalA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		4 / 8 LEU A 324
VAL A 356
LEU A 349
TYR A 257
 None
 0.91A 3v81C-4oalA:
undetectable		 3v81C-4oalA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 11 GLY A 146
GLY A 147
VAL A 153
ASP A 143
ILE A 236
 FAD  A 601 ( 4.2A)
None
None
DMS  A 604 ( 4.5A)
FAD  A 601 (-3.9A)
 0.96A 4pghA-4oalA:
undetectable		 4pghA-4oalA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 9 ALA A  84
VAL A 211
GLY A  79
ILE A 521
VAL A 205
 None
 1.10A 4r21B-4oalA:
undetectable		 4r21B-4oalA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 12 SER A 117
GLY A  97
GLY A 177
VAL A 176
THR A 179
 None
FAD  A 601 (-3.6A)
FAD  A 601 (-3.5A)
None
FAD  A 601 (-4.6A)
 1.30A 5o4yD-4oalA:
undetectable
5o4yE-4oalA:
undetectable		 5o4yD-4oalA:
2.83
5o4yE-4oalA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4oal CYTOKININ
DEHYDROGENASE 4
(Zea
mays) 		5 / 10 PRO A 131
ALA A 239
GLY A 177
THR A 179
ILE A 236
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 (-4.6A)
FAD  A 601 (-3.9A)
 1.32A 5vyhA-4oalA:
undetectable		 5vyhA-4oalA:
19.78