SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 6 HIS B 180
TYR B 135
ALA B 133
GLU B 131
None
None
None
A  C   3 ( 2.7A)
1.01A 1dmaB-4oavB:
undetectable
1dmaB-4oavB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 9 VAL B 418
VAL B 432
LEU B 408
ILE B 379
ALA B 390
None
None
None
ACP  B 801 (-4.0A)
ACP  B 801 (-3.2A)
1.09A 1eqgA-4oavB:
undetectable
1eqgA-4oavB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 11 VAL B 418
VAL B 432
LEU B 408
ILE B 379
ALA B 390
None
None
None
ACP  B 801 (-4.0A)
ACP  B 801 (-3.2A)
1.08A 1eqgB-4oavB:
undetectable
1eqgB-4oavB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 11 LEU B 707
GLU B 613
ILE B 614
LEU B 596
LEU B 663
None
1.35A 1mrqA-4oavB:
undetectable
1mrqA-4oavB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 8 ARG B 597
GLN B 693
PHE B 692
ASP B 687
None
1.31A 1rs6B-4oavB:
undetectable
1rs6B-4oavB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
LEU B 408
CYH B 437
LEU B 475
HIS B 483
ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.5A)
None
None
0.66A 1uwhA-4oavB:
17.1
1uwhA-4oavB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
LYS B 392
LEU B 408
CYH B 437
LEU B 475
HIS B 483
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
None
None
0.79A 1uwhB-4oavB:
17.1
1uwhB-4oavB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
3 / 3 PHE B 716
ARG B 597
ASN B 598
None
0.85A 1xzxX-4oavB:
undetectable
1xzxX-4oavB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 8 ARG B 597
GLN B 693
PHE B 692
ASP B 687
None
1.29A 1zzqA-4oavB:
undetectable
1zzqA-4oavB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 8 ARG B 597
GLN B 693
PHE B 692
ASP B 687
None
1.27A 1zzqB-4oavB:
undetectable
1zzqB-4oavB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 10 ALA B 128
PHE B 129
ALA B 133
LEU B 187
LEU B 108
None
1.06A 2bxqA-4oavB:
2.6
2bxqA-4oavB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 7 ALA B 169
GLY B 168
GLY B 167
ASN B 200
PHE B 126
A  C   3 ( 4.6A)
None
A  C   3 ( 4.4A)
None
A  C   3 ( 3.6A)
1.16A 2c49B-4oavB:
undetectable
2c49B-4oavB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
7 / 12 ILE B 371
LYS B 392
VAL B 418
ASN B 490
LEU B 492
ALA B 502
ASP B 503
ACP  B 801 (-4.2A)
ACP  B 801 (-2.8A)
None
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
None
MG  B 803 (-1.8A)
0.81A 2eufB-4oavB:
19.6
2eufB-4oavB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 LEU B 527
LEU B 524
LEU B 521
ILE B 491
LEU B 477
None
1.09A 2pnjA-4oavB:
undetectable
2pnjA-4oavB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ILE B 371
ALA B 502
THR B 440
LEU B 475
PHE B 504
ACP  B 801 (-4.2A)
None
ACP  B 801 (-4.1A)
None
None
1.08A 2y7hB-4oavB:
undetectable
2y7hB-4oavB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ILE B 371
ALA B 502
THR B 440
LEU B 475
PHE B 504
ACP  B 801 (-4.2A)
None
ACP  B 801 (-4.1A)
None
None
1.07A 2y7hC-4oavB:
undetectable
2y7hC-4oavB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
None
None
None
ACP  B 801 (-4.5A)
None
0.74A 3ik3A-4oavB:
16.8
3ik3A-4oavB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
LEU B 417
HIS B 483
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
None
None
ACP  B 801 (-4.5A)
None
0.57A 3ik3B-4oavB:
16.6
3ik3B-4oavB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
None
None
None
ACP  B 801 (-4.5A)
None
0.70A 3ik3B-4oavB:
16.6
3ik3B-4oavB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
3 / 3 ASP B 485
ARG B 400
LYS B 506
MG  B 803 (-4.7A)
ACP  B 801 (-3.1A)
ACP  B 801 ( 4.8A)
0.95A 3wipG-4oavB:
undetectable
3wipG-4oavB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 11 ALA B 390
VAL B 418
VAL B 434
CYH B 437
LEU B 492
ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.8A)
ACP  B 801 (-4.5A)
ACP  B 801 (-4.5A)
0.55A 4agdA-4oavB:
17.0
4agdA-4oavB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 11 MET B 130
PHE B 126
GLY B 202
ARG B 154
GLU B 162
None
A  C   3 ( 3.6A)
None
None
None
1.48A 4dx7A-4oavB:
0.1
4dx7A-4oavB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 6 THR B  94
LEU B 144
ASN B 119
LEU B 153
None
1.20A 4nc3A-4oavB:
undetectable
4nc3A-4oavB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 6 ALA B 390
LYS B 392
THR B 440
LEU B 492
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
ACP  B 801 (-4.1A)
ACP  B 801 (-4.5A)
0.78A 4o0uA-4oavB:
17.2
4o0uA-4oavB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 8 ILE B 371
ALA B 390
ASN B 490
LEU B 492
ASP B 503
ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
0.55A 4ogrA-4oavB:
19.1
4ogrA-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 7 ALA B 390
CYH B 437
ASN B 490
LEU B 492
ASP B 503
ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
0.35A 4ogrE-4oavB:
18.8
4ogrE-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 9 ILE B 371
ALA B 390
CYH B 437
ASN B 490
LEU B 492
ASP B 503
ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
0.58A 4ogrI-4oavB:
19.0
4ogrI-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
GLU B 404
VAL B 434
LEU B 475
ALA B 502
ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.8A)
None
None
0.99A 4qrcA-4oavB:
17.7
4qrcA-4oavB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
3 / 3 ASP B 189
HIS B 228
LYS B 185
None
0.94A 4qzuD-4oavB:
undetectable
4qzuD-4oavB:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 10 ILE B 371
ALA B 390
LYS B 392
LEU B 436
LEU B 492
ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
ACP  B 801 ( 4.9A)
ACP  B 801 (-4.5A)
0.72A 4rz7A-4oavB:
16.4
4rz7A-4oavB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
GLU B 404
VAL B 434
CYH B 479
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.8A)
None
ACP  B 801 (-4.5A)
None
1.25A 4tyjA-4oavB:
17.7
4tyjA-4oavB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
VAL B 434
HIS B 483
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
ACP  B 801 (-4.5A)
None
0.65A 4tyjA-4oavB:
17.7
4tyjA-4oavB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
LYS B 392
LEU B 408
CYH B 437
HIS B 483
LEU B 492
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
None
ACP  B 801 (-4.5A)
0.59A 4u0iA-4oavB:
17.4
4u0iA-4oavB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
0.82A 4v01A-4oavB:
17.2
4v01A-4oavB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
0.73A 4v01B-4oavB:
17.6
4v01B-4oavB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
0.89A 4v04B-4oavB:
17.7
4v04B-4oavB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 GLY B 253
LEU B 254
ASP B 227
VAL B 218
VAL B 232
None
1.18A 4wnwA-4oavB:
undetectable
4wnwA-4oavB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 VAL B 389
ILE B 493
ILE B 491
ASN B 490
HIS B 500
None
None
None
MG  B 802 ( 2.5A)
None
1.09A 4xueA-4oavB:
undetectable
4xueA-4oavB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
LYS B 392
LEU B 408
CYH B 437
ASP B 503
PHE B 504
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
None
0.89A 4xv2B-4oavB:
17.2
4xv2B-4oavB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 5 LEU B 408
CYH B 437
LEU B 492
ASP B 503
None
ACP  B 801 (-4.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
0.86A 5mafA-4oavB:
19.4
5mafA-4oavB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
6 / 12 ALA B 390
LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
ACP  B 801 (-3.2A)
None
None
None
ACP  B 801 (-4.5A)
None
0.75A 5mo4A-4oavB:
14.0
5mo4A-4oavB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
5 / 12 VAL B  33
ASP B  37
GLU B  36
LEU B  63
ALA B  66
None
0.98A 5nd7B-4oavB:
undetectable
5nd7B-4oavB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 4 ASN B 414
SER B 467
ALA B 471
VAL B 472
None
1.34A 5nm5A-4oavB:
undetectable
5nm5A-4oavB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 8 ALA B 390
CYH B 437
LEU B 492
ASP B 503
ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
0.38A 5owrA-4oavB:
17.6
5owrA-4oavB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 4 VAL B 418
LEU B 436
ASN B 490
ASP B 503
None
ACP  B 801 ( 4.9A)
MG  B 802 ( 2.5A)
MG  B 803 (-1.8A)
0.88A 5vcyA-4oavB:
18.4
5vcyA-4oavB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 5 LEU B 285
ALA B 289
LEU B 292
LEU B 316
None
0.82A 5vkqA-4oavB:
15.8
5vkqD-4oavB:
12.6
5vkqA-4oavB:
19.31
5vkqD-4oavB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 5 LEU B 316
LEU B 285
ALA B 289
LEU B 292
None
0.80A 5vkqA-4oavB:
15.8
5vkqB-4oavB:
undetectable
5vkqA-4oavB:
19.31
5vkqB-4oavB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 5 LEU B 316
LEU B 285
ALA B 289
LEU B 292
None
0.76A 5vkqB-4oavB:
14.0
5vkqC-4oavB:
undetectable
5vkqB-4oavB:
19.31
5vkqC-4oavB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 5 LEU B 316
LEU B 285
ALA B 289
LEU B 292
None
0.83A 5vkqC-4oavB:
undetectable
5vkqD-4oavB:
12.6
5vkqC-4oavB:
19.31
5vkqD-4oavB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
3 / 3 PHE B 665
ASP B 661
LYS B 664
None
0.80A 6awtD-4oavB:
undetectable
6awtD-4oavB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)
4oav PROTEIN (RNASE L)
(Homo
sapiens)
4 / 7 ILE B 491
LEU B 501
LEU B 486
LEU B 577
None
0.66A 6g9bA-4oavB:
undetectable
6g9bB-4oavB:
undetectable
6g9bA-4oavB:
7.78
6g9bB-4oavB:
7.58