SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4obs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 6 LEU A 476
GLU A 508
ASP A 509
PRO A 510
 None
 1.21A 1ditH-4obsA:
undetectable
1ditP-4obsA:
undetectable		 1ditH-4obsA:
16.98
1ditP-4obsA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 11 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
 None
 1.10A 2bxeA-4obsA:
undetectable		 2bxeA-4obsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
 None
 1.15A 2bxeB-4obsA:
undetectable		 2bxeB-4obsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 11 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
 None
 1.15A 2bxgA-4obsA:
undetectable		 2bxgA-4obsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 6 HIS A  82
ASP A 624
ARG A 435
HIS A 539
 None
 1.46A 2r6vA-4obsA:
undetectable		 2r6vA-4obsA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 GLY A 391
VAL A  80
LEU A 126
ILE A 326
VAL A  77
 None
 0.84A 3frqB-4obsA:
undetectable		 3frqB-4obsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 LEU A 238
GLY A 219
GLY A 220
LEU A 132
ASP A 203
 None
 1.20A 3i5uA-4obsA:
undetectable		 3i5uA-4obsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 LEU A 238
GLY A 219
GLY A 220
LEU A 132
ASP A 203
 None
 1.20A 3i5uB-4obsA:
undetectable		 3i5uB-4obsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 ARG A  89
ASP A 298
HIS A 262
GLU A 182
GLU A 131
 None
 1.24A 3lmyB-4obsA:
6.0		 3lmyB-4obsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 11 LEU A 566
ARG A 597
LEU A 604
LEU A 564
LEU A 557
 None
None
None
None
GOL  A 910 ( 4.8A)
 1.41A 3ndvA-4obsA:
undetectable
3ndvB-4obsA:
undetectable		 3ndvA-4obsA:
21.21
3ndvB-4obsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 8 TYR A  64
LEU A  74
PHE A  52
TYR A 117
 None
 1.27A 3po7A-4obsA:
undetectable		 3po7A-4obsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 6 TYR A  76
THR A 366
LEU A 365
GLU A 508
 None
 0.94A 3ps9A-4obsA:
undetectable		 3ps9A-4obsA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 7 THR A 601
HIS A 539
TYR A 625
TYR A 581
 None
 1.34A 4a3uA-4obsA:
6.9		 4a3uA-4obsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 7 THR A 601
HIS A 539
TYR A 625
TYR A 581
 None
 1.35A 4a3uB-4obsA:
3.7		 4a3uB-4obsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 11 TYR A  64
LEU A 604
LEU A  74
PHE A  52
TYR A 117
 None
 1.23A 4a7aA-4obsA:
undetectable		 4a7aA-4obsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 6 THR A 601
HIS A 539
TYR A 625
TYR A 581
 None
 1.31A 4df2A-4obsA:
6.9		 4df2A-4obsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 5 ASP A 349
ASN A 350
ILE A  85
VAL A 322
 None
 1.27A 4hytA-4obsA:
undetectable		 4hytA-4obsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		3 / 3 PRO A 464
VAL A 540
HIS A 539
 None
 0.78A 4pevC-4obsA:
undetectable		 4pevC-4obsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		3 / 3 ASP A 115
LEU A 114
PHE A 111
 None
 0.69A 4pthA-4obsA:
undetectable		 4pthA-4obsA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 5 ARG A 210
GLY A 208
THR A 249
GLU A 207
 None
 1.09A 5btiA-4obsA:
undetectable
5btiB-4obsA:
2.1		 5btiA-4obsA:
22.13
5btiB-4obsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 ARG A 363
HIS A 185
VAL A 304
GLU A 299
GLU A 182
 CL  A 915 (-4.9A)
None
None
None
None
 1.37A 5hqaA-4obsA:
6.8		 5hqaA-4obsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 12 VAL A 172
LEU A  94
LEU A 159
ALA A 160
LEU A 218
 None
 1.15A 5nd7B-4obsA:
undetectable		 5nd7B-4obsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 5 ASP A 184
GLY A 236
PRO A 232
TRP A 235
 None
 1.27A 5nn8A-4obsA:
2.7		 5nn8A-4obsA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 5 TYR A 318
ARG A 313
THR A 364
LEU A 365
 None
CL  A 915 (-4.0A)
None
None
 1.41A 5z86J-4obsA:
undetectable		 5z86J-4obsA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		4 / 5 GLY A 485
ASP A 484
ARG A 492
GLN A 500
 None
 1.28A 5zrfB-4obsA:
undetectable		 5zrfB-4obsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 9 LEU A 261
SER A 260
ILE A 283
PRO A 342
ILE A 295
 None
 1.29A 6ef6A-4obsA:
undetectable		 6ef6A-4obsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 4obs ALPHA-L-IDURONIDASE
(Homo
sapiens) 		5 / 10 TYR A 258
ASP A 349
GLY A 222
ASP A 223
GLU A 182
 None
 1.18A 6mb9A-4obsA:
undetectable		 6mb9A-4obsA:
10.83