SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4obt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC
(Arabidopsis
thaliana) 		3 / 3 ALA A 199
VAL A 197
TRP A 158
 None
 0.93A 1gmkC-4obtA:
undetectable
1gmkD-4obtA:
undetectable		 1gmkC-4obtA:
6.35
1gmkD-4obtA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 VAL A  79
ASN A  10
ILE A  93
VAL A  41
LEU A  49
 None
 1.25A 2ft9A-4obtA:
undetectable		 2ft9A-4obtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 10 ILE A 151
VAL A 110
VAL A 161
ILE A 125
VAL A  92
 None
 0.96A 2nnjA-4obtA:
undetectable		 2nnjA-4obtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 6 GLN A 183
GLU A 184
ALA A 182
GLN A 224
 None
 1.38A 6f6jC-4obtA:
undetectable
6f6jD-4obtA:
undetectable		 6f6jC-4obtA:
22.37
6f6jD-4obtA:
22.37